Prediction of Development of Liver-Related Events by Transient Elastography in Hepatitis B Patients With Complete Virological Response on Antiviral Therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08

AUTHORS

Hye Won Lee, Eun Jin Yoo, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Young Kim, Sang Hoon Ahn, Kwang-Hyub Han

ABSTRACT

OBJECTIVES: In the era of antiviral therapy, the prognostic significance of serum hepatitis B virus (HBV) DNA level as a biological gradient substantially diminished, as most patients can achieve complete virological response (CVR). We aimed to investigate the predictive roles of liver stiffness (LS) for liver-related events (LREs) among patients with CVR. METHODS: We analyzed 192 patients with chronic HBV infection who achieved CVR (defined as HBV DNA <20 IU/ml) through entecavir therapy. LS values at CVR were measured using transient elastography. LREs were defined as any cirrhotic complication, hepatocellular carcinoma, and liver-related mortality. RESULTS: The median age of the patients was 49 years, and 134 (69.8%) were male. The median LS value at CVR was 8.8 kPa. During follow-up, LREs occurred in 25 (13.0%) patients. When the population was stratified into three groups (<8.0 kPa, 8.0-13.0 kPa, and >13.0 kPa), cumulative LRE incidences increased significantly in association with LS values (log-rank test, P=0.001). Patients with an LS value >13.0 kPa (hazard ratio (HR)=12.336, 95% confidence interval (CI) 1.335-114.010; P=0.027) and 8.0-13.0 kPa (HR=8.832, 95% CI 1.092-71.432; P=0.041) were at significantly greater risk compared with those with an LS value <8.0 kPa. On multivariate analysis, age and LS values were seen to be independent predictors (all P<0.05). When LS values were incorporated into the REACH-B scoring model instead of serum HBV DNA level, a better predictive performance was seen compared with a conventional approach (areas under the receiver operating characteristic curve, 0.814 vs. 0.629, respectively). CONCLUSIONS: LS values at CVR are useful for predicting forthcoming LRE development. Thus, in the era of potent antiviral therapy, tailored surveillance strategies might be established based upon LS values at CVR. More... »

PAGES

1241

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ajg.2014.157

DOI

http://dx.doi.org/10.1038/ajg.2014.157

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028189009

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24957159


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiviral Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Elasticity Imaging Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guanine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatitis B, Chronic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Function Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Republic of Korea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "The first two authors contributed equally to this work"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Hye Won", 
        "id": "sg:person.0604617375.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604617375.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "The first two authors contributed equally to this work"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Eun Jin", 
        "id": "sg:person.01357217770.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357217770.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Liver Cirrhosis Clinical Research Center, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Beom Kyung", 
        "id": "sg:person.0655222232.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655222232.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Liver Cirrhosis Clinical Research Center, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Seung Up", 
        "id": "sg:person.0635113514.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635113514.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Liver Cirrhosis Clinical Research Center, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Jun Yong", 
        "id": "sg:person.013553660774.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013553660774.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Liver Cirrhosis Clinical Research Center, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young", 
        "id": "sg:person.011772653660.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011772653660.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Brain Korea 21 Project for Medical Science, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Sang Hoon", 
        "id": "sg:person.0774377430.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774377430.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea", 
            "Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea", 
            "Brain Korea 21 Project for Medical Science, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Kwang-Hyub", 
        "id": "sg:person.010746275772.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010746275772.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/hep.23327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000029068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2012.05098.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000585350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4065/82.8.967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001585719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e31825079f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004282169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e31825079f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004282169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12072-008-9080-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004706730", 
          "https://doi.org/10.1007/s12072-008-9080-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.2043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005987118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1478-3231.2009.02172.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006381579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009417486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cld.2007.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013109894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/liv.12020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014139381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510290312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016179798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018751116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840080310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018936657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2002.33638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019546037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020410414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2012.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020630462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000347209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023851789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033364", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024714847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2005.069757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024726314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2893.2006.00811.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025039539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3350/cmh.2012.18.2.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030553296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.295.1.65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031524482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.12658", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033069999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0036676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035477509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.32.3.294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036424836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2009.05.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037972666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.11.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037992316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2008.157735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040092929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040221582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jgh.12478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040806631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.24121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043230814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200012060-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043252758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200012060-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043252758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70077-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044084980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044122735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0006-341x.2005.030814.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044144954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910300109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044646386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1007411423766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045231508", 
          "https://doi.org/10.1023/a:1007411423766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2007.04857.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046638799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.26301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047881478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2009.203166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048217433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e31829a7247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050892930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mcg.0b013e31829a7247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050892930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v19.i12.1890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071369129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077881049", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078291625", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-08", 
    "datePublishedReg": "2014-08-01", 
    "description": "OBJECTIVES: In the era of antiviral therapy, the prognostic significance of serum hepatitis B virus (HBV) DNA level as a biological gradient substantially diminished, as most patients can achieve complete virological response (CVR). We aimed to investigate the predictive roles of liver stiffness (LS) for liver-related events (LREs) among patients with CVR.\nMETHODS: We analyzed 192 patients with chronic HBV infection who achieved CVR (defined as HBV DNA <20 IU/ml) through entecavir therapy. LS values at CVR were measured using transient elastography. LREs were defined as any cirrhotic complication, hepatocellular carcinoma, and liver-related mortality.\nRESULTS: The median age of the patients was 49 years, and 134 (69.8%) were male. The median LS value at CVR was 8.8 kPa. During follow-up, LREs occurred in 25 (13.0%) patients. When the population was stratified into three groups (<8.0 kPa, 8.0-13.0 kPa, and >13.0 kPa), cumulative LRE incidences increased significantly in association with LS values (log-rank test, P=0.001). Patients with an LS value >13.0 kPa (hazard ratio (HR)=12.336, 95% confidence interval (CI) 1.335-114.010; P=0.027) and 8.0-13.0 kPa (HR=8.832, 95% CI 1.092-71.432; P=0.041) were at significantly greater risk compared with those with an LS value <8.0 kPa. On multivariate analysis, age and LS values were seen to be independent predictors (all P<0.05). When LS values were incorporated into the REACH-B scoring model instead of serum HBV DNA level, a better predictive performance was seen compared with a conventional approach (areas under the receiver operating characteristic curve, 0.814 vs. 0.629, respectively).\nCONCLUSIONS: LS values at CVR are useful for predicting forthcoming LRE development. Thus, in the era of potent antiviral therapy, tailored surveillance strategies might be established based upon LS values at CVR.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ajg.2014.157", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019809", 
        "issn": [
          "0002-9270", 
          "1572-0241"
        ], 
        "name": "The American Journal of Gastroenterology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "109"
      }
    ], 
    "name": "Prediction of Development of Liver-Related Events by Transient Elastography in Hepatitis B Patients With Complete Virological Response on Antiviral Therapy", 
    "pagination": "1241", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8649770b65b817894d5f0ee97d05307e2056db02c98da3e328fc28103735bb1a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24957159"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0421030"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ajg.2014.157"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028189009"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ajg.2014.157", 
      "https://app.dimensions.ai/details/publication/pub.1028189009"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000437.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ajg2014157"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ajg.2014.157'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ajg.2014.157'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ajg.2014.157'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ajg.2014.157'


 

This table displays all metadata directly associated to this object as RDF triples.

310 TRIPLES      21 PREDICATES      87 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ajg.2014.157 schema:about N17bd0d414a3641b6b14dc86c2f2eb072
2 N2995586b7b82412f95d8ee262c66a06a
3 N5837179c05d14c82b2b0a26a731d09f9
4 N5f7a0a5bd9d848738f47a94b2e2ff454
5 N7d775d8643a7464794a6b8fd15b83933
6 N7deb630ad6164b8a9e7097a6ad31aa69
7 N85c528f8ab9f40998c8a78853e801e48
8 N8bbeeba3ef2349c595c89829f1a857a0
9 N93cda3926a0442cb95d7c14d5946c59f
10 N9c79be4cdc3f4fff90a6eefd0d8ad0a3
11 N9cc9fdf2e9444380955f41c0b4bf066c
12 Na184ea2c736241e5bbd79a566b2670d4
13 Na9e647b12b6d40b3bf8f669869d6c3de
14 Ncac852b22ed046df936c0bdb2481a251
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N32765da933d64b8eb159d7f7d004803d
18 schema:citation sg:pub.10.1007/s12072-008-9080-3
19 sg:pub.10.1023/a:1007411423766
20 https://app.dimensions.ai/details/publication/pub.1077881049
21 https://app.dimensions.ai/details/publication/pub.1078291625
22 https://doi.org/10.1001/jama.295.1.65
23 https://doi.org/10.1002/hep.1840080310
24 https://doi.org/10.1002/hep.20506
25 https://doi.org/10.1002/hep.21420
26 https://doi.org/10.1002/hep.22056
27 https://doi.org/10.1002/hep.23190
28 https://doi.org/10.1002/hep.23327
29 https://doi.org/10.1002/hep.23785
30 https://doi.org/10.1002/hep.24121
31 https://doi.org/10.1002/hep.26301
32 https://doi.org/10.1002/hep.510290312
33 https://doi.org/10.1002/ijc.2910300109
34 https://doi.org/10.1016/j.cgh.2009.05.025
35 https://doi.org/10.1016/j.cld.2007.08.005
36 https://doi.org/10.1016/j.jhep.2012.02.010
37 https://doi.org/10.1016/s1470-2045(11)70077-8
38 https://doi.org/10.1053/j.gastro.2005.11.016
39 https://doi.org/10.1053/jhep.2002.33638
40 https://doi.org/10.1056/nejmoa033364
41 https://doi.org/10.1097/00042737-200012060-00019
42 https://doi.org/10.1097/mcg.0b013e31825079f1
43 https://doi.org/10.1097/mcg.0b013e31829a7247
44 https://doi.org/10.1111/apt.12658
45 https://doi.org/10.1111/j.0006-341x.2005.030814.x
46 https://doi.org/10.1111/j.1365-2036.2012.05098.x
47 https://doi.org/10.1111/j.1365-2893.2006.00811.x
48 https://doi.org/10.1111/j.1440-1746.2007.04857.x
49 https://doi.org/10.1111/j.1478-3231.2009.02172.x
50 https://doi.org/10.1111/jgh.12478
51 https://doi.org/10.1111/liv.12020
52 https://doi.org/10.1136/gut.2005.069757
53 https://doi.org/10.1136/gut.2008.157735
54 https://doi.org/10.1136/gut.2009.203166
55 https://doi.org/10.1136/gut.32.3.294
56 https://doi.org/10.1159/000347209
57 https://doi.org/10.1200/jco.2007.13.2043
58 https://doi.org/10.1371/journal.pone.0036676
59 https://doi.org/10.3350/cmh.2012.18.2.109
60 https://doi.org/10.3748/wjg.v19.i12.1890
61 https://doi.org/10.4065/82.8.967
62 schema:datePublished 2014-08
63 schema:datePublishedReg 2014-08-01
64 schema:description OBJECTIVES: In the era of antiviral therapy, the prognostic significance of serum hepatitis B virus (HBV) DNA level as a biological gradient substantially diminished, as most patients can achieve complete virological response (CVR). We aimed to investigate the predictive roles of liver stiffness (LS) for liver-related events (LREs) among patients with CVR. METHODS: We analyzed 192 patients with chronic HBV infection who achieved CVR (defined as HBV DNA <20 IU/ml) through entecavir therapy. LS values at CVR were measured using transient elastography. LREs were defined as any cirrhotic complication, hepatocellular carcinoma, and liver-related mortality. RESULTS: The median age of the patients was 49 years, and 134 (69.8%) were male. The median LS value at CVR was 8.8 kPa. During follow-up, LREs occurred in 25 (13.0%) patients. When the population was stratified into three groups (<8.0 kPa, 8.0-13.0 kPa, and >13.0 kPa), cumulative LRE incidences increased significantly in association with LS values (log-rank test, P=0.001). Patients with an LS value >13.0 kPa (hazard ratio (HR)=12.336, 95% confidence interval (CI) 1.335-114.010; P=0.027) and 8.0-13.0 kPa (HR=8.832, 95% CI 1.092-71.432; P=0.041) were at significantly greater risk compared with those with an LS value <8.0 kPa. On multivariate analysis, age and LS values were seen to be independent predictors (all P<0.05). When LS values were incorporated into the REACH-B scoring model instead of serum HBV DNA level, a better predictive performance was seen compared with a conventional approach (areas under the receiver operating characteristic curve, 0.814 vs. 0.629, respectively). CONCLUSIONS: LS values at CVR are useful for predicting forthcoming LRE development. Thus, in the era of potent antiviral therapy, tailored surveillance strategies might be established based upon LS values at CVR.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree false
68 schema:isPartOf N69442a92a47f4830ba7f17c01e45a7df
69 N84477f59ca774c7ab38b8ac8ce022ef5
70 sg:journal.1019809
71 schema:name Prediction of Development of Liver-Related Events by Transient Elastography in Hepatitis B Patients With Complete Virological Response on Antiviral Therapy
72 schema:pagination 1241
73 schema:productId N4c66939f2fc04317be4d8915179f0905
74 N6063e66297844877af5c3cbedcfa422a
75 Nbdd43d0778b6416caff3ace20823fced
76 Ncce6cb1297f74e77bd5cc4e854a424ad
77 Nd148e3097a2a41ceb3ece68d4f5727c1
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028189009
79 https://doi.org/10.1038/ajg.2014.157
80 schema:sdDatePublished 2019-04-10T21:26
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N7724e9d5f2574d6ba2db9ec13f1f7f9f
83 schema:url https://www.nature.com/articles/ajg2014157
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N17bd0d414a3641b6b14dc86c2f2eb072 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Elasticity Imaging Techniques
89 rdf:type schema:DefinedTerm
90 N2995586b7b82412f95d8ee262c66a06a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Republic of Korea
92 rdf:type schema:DefinedTerm
93 N32765da933d64b8eb159d7f7d004803d rdf:first sg:person.0604617375.89
94 rdf:rest Nc645af144ccc4369813ae7c5e2df72c2
95 N4c66939f2fc04317be4d8915179f0905 schema:name dimensions_id
96 schema:value pub.1028189009
97 rdf:type schema:PropertyValue
98 N512d16bf8653487fa75c4baeb6e9fcc0 rdf:first sg:person.011772653660.43
99 rdf:rest Nf576a69ed85d43bbb396e9a1e541542f
100 N53ca23c652974e0cb4c679b538b1194e rdf:first sg:person.0655222232.12
101 rdf:rest N8ee27bf4b0a14b5ebb1c2278d577cad6
102 N5837179c05d14c82b2b0a26a731d09f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Liver Function Tests
104 rdf:type schema:DefinedTerm
105 N5f7a0a5bd9d848738f47a94b2e2ff454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Antiviral Agents
107 rdf:type schema:DefinedTerm
108 N6063e66297844877af5c3cbedcfa422a schema:name nlm_unique_id
109 schema:value 0421030
110 rdf:type schema:PropertyValue
111 N69442a92a47f4830ba7f17c01e45a7df schema:issueNumber 8
112 rdf:type schema:PublicationIssue
113 N7724e9d5f2574d6ba2db9ec13f1f7f9f schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 N7d775d8643a7464794a6b8fd15b83933 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Adult
117 rdf:type schema:DefinedTerm
118 N7deb630ad6164b8a9e7097a6ad31aa69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Middle Aged
120 rdf:type schema:DefinedTerm
121 N84477f59ca774c7ab38b8ac8ce022ef5 schema:volumeNumber 109
122 rdf:type schema:PublicationVolume
123 N85c528f8ab9f40998c8a78853e801e48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Male
125 rdf:type schema:DefinedTerm
126 N8646123823a849cfa77bcf34b9b120e3 rdf:first sg:person.013553660774.88
127 rdf:rest N512d16bf8653487fa75c4baeb6e9fcc0
128 N8a6cf954ceb64f5297231651f32c2d64 rdf:first sg:person.010746275772.51
129 rdf:rest rdf:nil
130 N8bbeeba3ef2349c595c89829f1a857a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 N8ee27bf4b0a14b5ebb1c2278d577cad6 rdf:first sg:person.0635113514.09
134 rdf:rest N8646123823a849cfa77bcf34b9b120e3
135 N93cda3926a0442cb95d7c14d5946c59f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Biomarkers, Tumor
137 rdf:type schema:DefinedTerm
138 N9c79be4cdc3f4fff90a6eefd0d8ad0a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Prospective Studies
140 rdf:type schema:DefinedTerm
141 N9cc9fdf2e9444380955f41c0b4bf066c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Hepatitis B, Chronic
143 rdf:type schema:DefinedTerm
144 Na184ea2c736241e5bbd79a566b2670d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Guanine
146 rdf:type schema:DefinedTerm
147 Na9e647b12b6d40b3bf8f669869d6c3de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 Nbdd43d0778b6416caff3ace20823fced schema:name doi
151 schema:value 10.1038/ajg.2014.157
152 rdf:type schema:PropertyValue
153 Nc645af144ccc4369813ae7c5e2df72c2 rdf:first sg:person.01357217770.18
154 rdf:rest N53ca23c652974e0cb4c679b538b1194e
155 Ncac852b22ed046df936c0bdb2481a251 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Predictive Value of Tests
157 rdf:type schema:DefinedTerm
158 Ncce6cb1297f74e77bd5cc4e854a424ad schema:name readcube_id
159 schema:value 8649770b65b817894d5f0ee97d05307e2056db02c98da3e328fc28103735bb1a
160 rdf:type schema:PropertyValue
161 Nd148e3097a2a41ceb3ece68d4f5727c1 schema:name pubmed_id
162 schema:value 24957159
163 rdf:type schema:PropertyValue
164 Nf576a69ed85d43bbb396e9a1e541542f rdf:first sg:person.0774377430.78
165 rdf:rest N8a6cf954ceb64f5297231651f32c2d64
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
170 schema:name Clinical Sciences
171 rdf:type schema:DefinedTerm
172 sg:journal.1019809 schema:issn 0002-9270
173 1572-0241
174 schema:name The American Journal of Gastroenterology
175 rdf:type schema:Periodical
176 sg:person.010746275772.51 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
177 schema:familyName Han
178 schema:givenName Kwang-Hyub
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010746275772.51
180 rdf:type schema:Person
181 sg:person.011772653660.43 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
182 schema:familyName Kim
183 schema:givenName Young
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011772653660.43
185 rdf:type schema:Person
186 sg:person.013553660774.88 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
187 schema:familyName Park
188 schema:givenName Jun Yong
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013553660774.88
190 rdf:type schema:Person
191 sg:person.01357217770.18 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
192 schema:familyName Yoo
193 schema:givenName Eun Jin
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357217770.18
195 rdf:type schema:Person
196 sg:person.0604617375.89 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
197 schema:familyName Lee
198 schema:givenName Hye Won
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604617375.89
200 rdf:type schema:Person
201 sg:person.0635113514.09 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
202 schema:familyName Kim
203 schema:givenName Seung Up
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635113514.09
205 rdf:type schema:Person
206 sg:person.0655222232.12 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
207 schema:familyName Kim
208 schema:givenName Beom Kyung
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655222232.12
210 rdf:type schema:Person
211 sg:person.0774377430.78 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
212 schema:familyName Ahn
213 schema:givenName Sang Hoon
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774377430.78
215 rdf:type schema:Person
216 sg:pub.10.1007/s12072-008-9080-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004706730
217 https://doi.org/10.1007/s12072-008-9080-3
218 rdf:type schema:CreativeWork
219 sg:pub.10.1023/a:1007411423766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045231508
220 https://doi.org/10.1023/a:1007411423766
221 rdf:type schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1077881049 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1078291625 schema:CreativeWork
224 https://doi.org/10.1001/jama.295.1.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031524482
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/hep.1840080310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018936657
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1002/hep.20506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009417486
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/hep.21420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020410414
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/hep.22056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044122735
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/hep.23190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018751116
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1002/hep.23327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000029068
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1002/hep.23785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040221582
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1002/hep.24121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043230814
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/hep.26301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047881478
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/hep.510290312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016179798
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/ijc.2910300109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044646386
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.cgh.2009.05.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037972666
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.cld.2007.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013109894
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.jhep.2012.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020630462
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/s1470-2045(11)70077-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044084980
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1053/j.gastro.2005.11.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037992316
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1053/jhep.2002.33638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019546037
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1056/nejmoa033364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024714847
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/00042737-200012060-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043252758
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1097/mcg.0b013e31825079f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004282169
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1097/mcg.0b013e31829a7247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050892930
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/apt.12658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033069999
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.0006-341x.2005.030814.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044144954
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2036.2012.05098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000585350
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1365-2893.2006.00811.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025039539
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1440-1746.2007.04857.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046638799
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1478-3231.2009.02172.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006381579
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/jgh.12478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040806631
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1111/liv.12020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014139381
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1136/gut.2005.069757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024726314
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1136/gut.2008.157735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040092929
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1136/gut.2009.203166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048217433
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1136/gut.32.3.294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036424836
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1159/000347209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023851789
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2007.13.2043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005987118
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1371/journal.pone.0036676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035477509
297 rdf:type schema:CreativeWork
298 https://doi.org/10.3350/cmh.2012.18.2.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030553296
299 rdf:type schema:CreativeWork
300 https://doi.org/10.3748/wjg.v19.i12.1890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071369129
301 rdf:type schema:CreativeWork
302 https://doi.org/10.4065/82.8.967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001585719
303 rdf:type schema:CreativeWork
304 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
305 schema:name Brain Korea 21 Project for Medical Science, Seoul, Korea
306 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
307 Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea
308 Liver Cirrhosis Clinical Research Center, Seoul, Korea
309 The first two authors contributed equally to this work
310 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...