Extrahepatic Portal Venous System Thrombosis in Recurrent Acute and Chronic Alcoholic Pancreatitis Is Caused by Local Inflammation and Not Thrombophilia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07-24

AUTHORS

Vinciane Rebours, Larbi Boudaoud, Marie-Pierre Vullierme, Dominique Vidaud, Bertrand Condat, Olivia Hentic, Frédérique Maire, Pascal Hammel, Philippe Ruszniewski, Philippe Lévy

ABSTRACT

OBJECTIVES: Extrahepatic portal venous system thrombosis (EPVST) occurs in 13% of patients with either recurrent acute (AP) or chronic (CP) alcoholic pancreatitis. The role of thrombophilia has never been assessed in this entity. METHODS: All consecutive patients with alcoholic AP or CP were included in a prospective study. All patients underwent a computerized tomography (CT) scan of the pancreas to evaluate EPVST as well as thorough testing for thrombophilia (protein C, S, and antithrombin deficiency, factor II, factor V, and JAK2 gene mutations, homocystein, biological antiphospholipid syndrome). RESULTS: A total of 119 patients (male, n=100 (84%); smokers, n=110 (92%)) were included. EPVST was found in 41 patients (35%). The portal, superior mesenteric, or splenic veins were involved in 34%, 24%, and 93% of patients, respectively. Thrombophilia was identified in 18% (n=22), including the biological antiphospholipid syndrome, factor V Leiden mutation, and factor II G20210A gene mutation in 21 (17.6%), 2 (1.6%), and 1 patient (0.8%), respectively. On univariate analysis, the factors associated with EPVST were smoking (RR=1.6 (1.38-1.85), P=0.03), pseudocysts (RR=2.91 (1.29-6.56), P=0.008), a pseudocyst in the pancreatic tail (P=0.03), a high CT severity index for AP (P=0.007), and pancreatic parenchymal necrosis (P=0.02). The presence of hemostatic risk factors was not associated with an increased risk of EPVST. On multivariate analysis, only pseudocysts were associated with EPVST (hazard ratio: 6.402; 95% confidence interval (1.59-26.54), P=0.009). CONCLUSIONS: EPVST is found in 35% of patients with acute/chronic alcoholic pancreatitis. Local inflammation appears to be the major predisposing condition. The presence of some form of thrombophilia does not increase the risk of EPVST and should not be systematically searched for in case of EPVST. More... »

PAGES

1579

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ajg.2012.231

DOI

http://dx.doi.org/10.1038/ajg.2012.231

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040053417

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22825367


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alcoholism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chronic Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Portal Vein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Smoking", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombophilia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tomography, X-Ray Computed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Venous Thrombosis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rebours", 
        "givenName": "Vinciane", 
        "id": "sg:person.01017252245.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017252245.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le de Biologie, d\u2019Imagerie, de Pathologie et de Pharmacie, Service d\u2019H\u00e9matologie et d\u2019H\u00e9mostase biologique, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le de Biologie, d\u2019Imagerie, de Pathologie et de Pharmacie, Service d\u2019H\u00e9matologie et d\u2019H\u00e9mostase biologique, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boudaoud", 
        "givenName": "Larbi", 
        "id": "sg:person.01205632314.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205632314.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le de Biologie, d\u2019Imagerie, de Pathologie et de Pharmacie, Service de Radiologie, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le de Biologie, d\u2019Imagerie, de Pathologie et de Pharmacie, Service de Radiologie, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vullierme", 
        "givenName": "Marie-Pierre", 
        "id": "sg:person.01231224366.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231224366.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le de Biologie, d\u2019Imagerie, de Pathologie et de Pharmacie, Service de Biochimie et de g\u00e9n\u00e9tique, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le de Biologie, d\u2019Imagerie, de Pathologie et de Pharmacie, Service de Biochimie et de g\u00e9n\u00e9tique, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidaud", 
        "givenName": "Dominique", 
        "id": "sg:person.0636012046.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636012046.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service d\u2019H\u00e9patologie, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service d\u2019H\u00e9patologie, H\u00f4pital Beaujon, AP-HP, Clichy, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Condat", 
        "givenName": "Bertrand", 
        "id": "sg:person.01027346503.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027346503.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hentic", 
        "givenName": "Olivia", 
        "id": "sg:person.0736275266.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736275266.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maire", 
        "givenName": "Fr\u00e9d\u00e9rique", 
        "id": "sg:person.01351504544.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351504544.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hammel", 
        "givenName": "Pascal", 
        "id": "sg:person.01355345644.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355345644.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruszniewski", 
        "givenName": "Philippe", 
        "id": "sg:person.0640551545.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640551545.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France", 
          "id": "http://www.grid.ac/institutes/grid.411599.1", 
          "name": [
            "P\u00f4le des Maladies de l\u2019Appareil Digestif, Service de Gastroent\u00e9rologie\u2013Pancr\u00e9atologie, H\u00f4pital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Universit\u00e9 Paris-Diderot, Clichy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00e9vy", 
        "givenName": "Philippe", 
        "id": "sg:person.0740232450.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740232450.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/369064a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024264501", 
          "https://doi.org/10.1038/369064a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01307725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019659676", 
          "https://doi.org/10.1007/bf01307725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-003-7247-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049727592", 
          "https://doi.org/10.1007/s00268-003-7247-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2404069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051453814", 
          "https://doi.org/10.1038/sj.leu.2404069"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-07-24", 
    "datePublishedReg": "2012-07-24", 
    "description": "OBJECTIVES: Extrahepatic portal venous system thrombosis (EPVST) occurs in 13% of patients with either recurrent acute (AP) or chronic (CP) alcoholic pancreatitis. The role of thrombophilia has never been assessed in this entity.\nMETHODS: All consecutive patients with alcoholic AP or CP were included in a prospective study. All patients underwent a computerized tomography (CT) scan of the pancreas to evaluate EPVST as well as thorough testing for thrombophilia (protein C, S, and antithrombin deficiency, factor II, factor V, and JAK2 gene mutations, homocystein, biological antiphospholipid syndrome).\nRESULTS: A total of 119 patients (male, n=100 (84%); smokers, n=110 (92%)) were included. EPVST was found in 41 patients (35%). The portal, superior mesenteric, or splenic veins were involved in 34%, 24%, and 93% of patients, respectively. Thrombophilia was identified in 18% (n=22), including the biological antiphospholipid syndrome, factor V Leiden mutation, and factor II G20210A gene mutation in 21 (17.6%), 2 (1.6%), and 1 patient (0.8%), respectively. On univariate analysis, the factors associated with EPVST were smoking (RR=1.6 (1.38-1.85), P=0.03), pseudocysts (RR=2.91 (1.29-6.56), P=0.008), a pseudocyst in the pancreatic tail (P=0.03), a high CT severity index for AP (P=0.007), and pancreatic parenchymal necrosis (P=0.02). The presence of hemostatic risk factors was not associated with an increased risk of EPVST. On multivariate analysis, only pseudocysts were associated with EPVST (hazard ratio: 6.402; 95% confidence interval (1.59-26.54), P=0.009).\nCONCLUSIONS: EPVST is found in 35% of patients with acute/chronic alcoholic pancreatitis. Local inflammation appears to be the major predisposing condition. The presence of some form of thrombophilia does not increase the risk of EPVST and should not be systematically searched for in case of EPVST.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ajg.2012.231", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1019809", 
        "issn": [
          "0002-9270", 
          "1572-0241"
        ], 
        "name": "The American Journal of Gastroenterology", 
        "publisher": "Wolters Kluwer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "107"
      }
    ], 
    "keywords": [
      "chronic alcoholic pancreatitis", 
      "portal venous system thrombosis", 
      "alcoholic pancreatitis", 
      "local inflammation", 
      "high CT severity index", 
      "role of thrombophilia", 
      "CT severity index", 
      "pancreatic parenchymal necrosis", 
      "major predisposing condition", 
      "factor V Leiden mutation", 
      "hemostatic risk factors", 
      "computerized tomography scan", 
      "forms of thrombophilia", 
      "Recurrent Acute", 
      "superior mesenteric", 
      "consecutive patients", 
      "antiphospholipid syndrome", 
      "pancreatic tail", 
      "parenchymal necrosis", 
      "predisposing condition", 
      "prospective study", 
      "splenic vein", 
      "risk factors", 
      "tomography scan", 
      "univariate analysis", 
      "patients", 
      "Leiden mutation", 
      "thrombophilia", 
      "multivariate analysis", 
      "pancreatitis", 
      "pseudocyst", 
      "Severity Index", 
      "gene mutations", 
      "thrombosis", 
      "inflammation", 
      "risk", 
      "mesenteric", 
      "Acute", 
      "syndrome", 
      "pancreas", 
      "necrosis", 
      "mutations", 
      "vein", 
      "scans", 
      "factors", 
      "total", 
      "AP", 
      "presence", 
      "index", 
      "entities", 
      "testing", 
      "study", 
      "cases", 
      "role", 
      "analysis", 
      "CP", 
      "thorough testing", 
      "conditions", 
      "form", 
      "tail", 
      "EPVST", 
      "venous system thrombosis", 
      "system thrombosis", 
      "alcoholic AP", 
      "biological antiphospholipid syndrome", 
      "V Leiden mutation", 
      "factor II G20210A gene mutation", 
      "II G20210A gene mutation", 
      "G20210A gene mutation", 
      "risk of EPVST", 
      "case of EPVST"
    ], 
    "name": "Extrahepatic Portal Venous System Thrombosis in Recurrent Acute and Chronic Alcoholic Pancreatitis Is Caused by Local Inflammation and Not Thrombophilia", 
    "pagination": "1579", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040053417"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ajg.2012.231"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22825367"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ajg.2012.231", 
      "https://app.dimensions.ai/details/publication/pub.1040053417"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_570.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ajg.2012.231"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ajg.2012.231'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ajg.2012.231'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ajg.2012.231'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ajg.2012.231'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      22 PREDICATES      122 URIs      110 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ajg.2012.231 schema:about N02cbc77a1fbf45d8a3a66d447fe0ad58
2 N088c0187d94f49c78a9f9f20189d929b
3 N0d606db889484d4caccc249c58e1e205
4 N3950820659804a59a03dcafb78bd4a2c
5 N4d597881bdb240efaca56381917d126e
6 N4edced12f5904f3495fa1079dffe9612
7 N6b184e4734af494ab523df7c2251630c
8 N8397ef75f9df415487aab836a6142668
9 N983c4fab312c4f5ea9e2f324a380e487
10 Na8d3b171f54a47bdb14544fffd0eddbe
11 Nb481966871cc409896ec1b21ef68140f
12 Nd2b7f0df97274347816a4f158b941a41
13 Nd38aa6e5a75a41e9a9f455c9a7fed517
14 Ndf4e5297831e4c0c996e96aecdbed3fa
15 Ne01ddcbb8dbe4387a6382e036bc927c6
16 Ne7acba7ea2414e339b4eb11679f1e9c9
17 Ne7c334e60ae14dadafe6924ee2699710
18 Nea7884aa4660471b99f347bf55a383dc
19 Nf239bf11d30e4b8a951a8acd573435f0
20 Nf411b056f7864688b66a0b1f2219e479
21 Nffe5c00cbcfa4437b72952ce223e4c76
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author N050361ee57b84d3191e88a2768996205
25 schema:citation sg:pub.10.1007/bf01307725
26 sg:pub.10.1007/s00268-003-7247-6
27 sg:pub.10.1038/369064a0
28 sg:pub.10.1038/sj.leu.2404069
29 schema:datePublished 2012-07-24
30 schema:datePublishedReg 2012-07-24
31 schema:description OBJECTIVES: Extrahepatic portal venous system thrombosis (EPVST) occurs in 13% of patients with either recurrent acute (AP) or chronic (CP) alcoholic pancreatitis. The role of thrombophilia has never been assessed in this entity. METHODS: All consecutive patients with alcoholic AP or CP were included in a prospective study. All patients underwent a computerized tomography (CT) scan of the pancreas to evaluate EPVST as well as thorough testing for thrombophilia (protein C, S, and antithrombin deficiency, factor II, factor V, and JAK2 gene mutations, homocystein, biological antiphospholipid syndrome). RESULTS: A total of 119 patients (male, n=100 (84%); smokers, n=110 (92%)) were included. EPVST was found in 41 patients (35%). The portal, superior mesenteric, or splenic veins were involved in 34%, 24%, and 93% of patients, respectively. Thrombophilia was identified in 18% (n=22), including the biological antiphospholipid syndrome, factor V Leiden mutation, and factor II G20210A gene mutation in 21 (17.6%), 2 (1.6%), and 1 patient (0.8%), respectively. On univariate analysis, the factors associated with EPVST were smoking (RR=1.6 (1.38-1.85), P=0.03), pseudocysts (RR=2.91 (1.29-6.56), P=0.008), a pseudocyst in the pancreatic tail (P=0.03), a high CT severity index for AP (P=0.007), and pancreatic parenchymal necrosis (P=0.02). The presence of hemostatic risk factors was not associated with an increased risk of EPVST. On multivariate analysis, only pseudocysts were associated with EPVST (hazard ratio: 6.402; 95% confidence interval (1.59-26.54), P=0.009). CONCLUSIONS: EPVST is found in 35% of patients with acute/chronic alcoholic pancreatitis. Local inflammation appears to be the major predisposing condition. The presence of some form of thrombophilia does not increase the risk of EPVST and should not be systematically searched for in case of EPVST.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N63d21fd1275e4658aec636f471ff277c
36 N8bf2629ceb7d463687e03cef4d363e72
37 sg:journal.1019809
38 schema:keywords AP
39 Acute
40 CP
41 CT severity index
42 EPVST
43 G20210A gene mutation
44 II G20210A gene mutation
45 Leiden mutation
46 Recurrent Acute
47 Severity Index
48 V Leiden mutation
49 alcoholic AP
50 alcoholic pancreatitis
51 analysis
52 antiphospholipid syndrome
53 biological antiphospholipid syndrome
54 case of EPVST
55 cases
56 chronic alcoholic pancreatitis
57 computerized tomography scan
58 conditions
59 consecutive patients
60 entities
61 factor II G20210A gene mutation
62 factor V Leiden mutation
63 factors
64 form
65 forms of thrombophilia
66 gene mutations
67 hemostatic risk factors
68 high CT severity index
69 index
70 inflammation
71 local inflammation
72 major predisposing condition
73 mesenteric
74 multivariate analysis
75 mutations
76 necrosis
77 pancreas
78 pancreatic parenchymal necrosis
79 pancreatic tail
80 pancreatitis
81 parenchymal necrosis
82 patients
83 portal venous system thrombosis
84 predisposing condition
85 presence
86 prospective study
87 pseudocyst
88 risk
89 risk factors
90 risk of EPVST
91 role
92 role of thrombophilia
93 scans
94 splenic vein
95 study
96 superior mesenteric
97 syndrome
98 system thrombosis
99 tail
100 testing
101 thorough testing
102 thrombophilia
103 thrombosis
104 tomography scan
105 total
106 univariate analysis
107 vein
108 venous system thrombosis
109 schema:name Extrahepatic Portal Venous System Thrombosis in Recurrent Acute and Chronic Alcoholic Pancreatitis Is Caused by Local Inflammation and Not Thrombophilia
110 schema:pagination 1579
111 schema:productId N00b9976d1a96440991304ef7b274918d
112 N014bba3c74184e368e8281a25f01d381
113 N519931bf0af040f9ba1ecd45a9d9d40e
114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040053417
115 https://doi.org/10.1038/ajg.2012.231
116 schema:sdDatePublished 2021-11-01T18:18
117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
118 schema:sdPublisher Na28dba0414634ab2a9a12ea26a8d6507
119 schema:url https://doi.org/10.1038/ajg.2012.231
120 sgo:license sg:explorer/license/
121 sgo:sdDataset articles
122 rdf:type schema:ScholarlyArticle
123 N00b9976d1a96440991304ef7b274918d schema:name pubmed_id
124 schema:value 22825367
125 rdf:type schema:PropertyValue
126 N014bba3c74184e368e8281a25f01d381 schema:name doi
127 schema:value 10.1038/ajg.2012.231
128 rdf:type schema:PropertyValue
129 N02cbc77a1fbf45d8a3a66d447fe0ad58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Alcoholism
131 rdf:type schema:DefinedTerm
132 N050361ee57b84d3191e88a2768996205 rdf:first sg:person.01017252245.99
133 rdf:rest Nd5abb65301fe433fb5fc5624b5702fd3
134 N088c0187d94f49c78a9f9f20189d929b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Acute Disease
136 rdf:type schema:DefinedTerm
137 N0d606db889484d4caccc249c58e1e205 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Tomography, X-Ray Computed
139 rdf:type schema:DefinedTerm
140 N15e88d12b4954b7ba5f5355cefee0ede rdf:first sg:person.0740232450.15
141 rdf:rest rdf:nil
142 N300e16af9ca74f988b1ce0688e0088eb rdf:first sg:person.01355345644.55
143 rdf:rest Nc0f619003b444294b84c2876c6cafefe
144 N3778bf4bff90404f8b7106e1c6200463 rdf:first sg:person.01231224366.16
145 rdf:rest N98f1932bd7024f26968a8f71b5178481
146 N3950820659804a59a03dcafb78bd4a2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Venous Thrombosis
148 rdf:type schema:DefinedTerm
149 N4d597881bdb240efaca56381917d126e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Aged
151 rdf:type schema:DefinedTerm
152 N4edced12f5904f3495fa1079dffe9612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Thrombophilia
154 rdf:type schema:DefinedTerm
155 N519931bf0af040f9ba1ecd45a9d9d40e schema:name dimensions_id
156 schema:value pub.1040053417
157 rdf:type schema:PropertyValue
158 N63d21fd1275e4658aec636f471ff277c schema:issueNumber 10
159 rdf:type schema:PublicationIssue
160 N6b184e4734af494ab523df7c2251630c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adult
162 rdf:type schema:DefinedTerm
163 N73ad5d2a75ad4ca0b5c42e9f9628b202 rdf:first sg:person.01351504544.65
164 rdf:rest N300e16af9ca74f988b1ce0688e0088eb
165 N8397ef75f9df415487aab836a6142668 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 N8bf2629ceb7d463687e03cef4d363e72 schema:volumeNumber 107
169 rdf:type schema:PublicationVolume
170 N983c4fab312c4f5ea9e2f324a380e487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Recurrence
172 rdf:type schema:DefinedTerm
173 N98f1932bd7024f26968a8f71b5178481 rdf:first sg:person.0636012046.73
174 rdf:rest Ne95810989f6b42ad9d4698feb4f5ee36
175 Na28dba0414634ab2a9a12ea26a8d6507 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Na8d3b171f54a47bdb14544fffd0eddbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Risk Factors
179 rdf:type schema:DefinedTerm
180 Nb481966871cc409896ec1b21ef68140f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Odds Ratio
182 rdf:type schema:DefinedTerm
183 Nc0f619003b444294b84c2876c6cafefe rdf:first sg:person.0640551545.21
184 rdf:rest N15e88d12b4954b7ba5f5355cefee0ede
185 Nd2b7f0df97274347816a4f158b941a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Inflammation
187 rdf:type schema:DefinedTerm
188 Nd38aa6e5a75a41e9a9f455c9a7fed517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Portal Vein
190 rdf:type schema:DefinedTerm
191 Nd5abb65301fe433fb5fc5624b5702fd3 rdf:first sg:person.01205632314.02
192 rdf:rest N3778bf4bff90404f8b7106e1c6200463
193 Ndd809d53176e497992a5234e85322928 rdf:first sg:person.0736275266.26
194 rdf:rest N73ad5d2a75ad4ca0b5c42e9f9628b202
195 Ndf4e5297831e4c0c996e96aecdbed3fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Pancreatitis
197 rdf:type schema:DefinedTerm
198 Ne01ddcbb8dbe4387a6382e036bc927c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Smoking
200 rdf:type schema:DefinedTerm
201 Ne7acba7ea2414e339b4eb11679f1e9c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Prospective Studies
203 rdf:type schema:DefinedTerm
204 Ne7c334e60ae14dadafe6924ee2699710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Middle Aged
206 rdf:type schema:DefinedTerm
207 Ne95810989f6b42ad9d4698feb4f5ee36 rdf:first sg:person.01027346503.62
208 rdf:rest Ndd809d53176e497992a5234e85322928
209 Nea7884aa4660471b99f347bf55a383dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Female
211 rdf:type schema:DefinedTerm
212 Nf239bf11d30e4b8a951a8acd573435f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Male
214 rdf:type schema:DefinedTerm
215 Nf411b056f7864688b66a0b1f2219e479 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Chronic Disease
217 rdf:type schema:DefinedTerm
218 Nffe5c00cbcfa4437b72952ce223e4c76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Analysis of Variance
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
225 schema:name Clinical Sciences
226 rdf:type schema:DefinedTerm
227 sg:journal.1019809 schema:issn 0002-9270
228 1572-0241
229 schema:name The American Journal of Gastroenterology
230 schema:publisher Wolters Kluwer
231 rdf:type schema:Periodical
232 sg:person.01017252245.99 schema:affiliation grid-institutes:grid.411599.1
233 schema:familyName Rebours
234 schema:givenName Vinciane
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017252245.99
236 rdf:type schema:Person
237 sg:person.01027346503.62 schema:affiliation grid-institutes:grid.411599.1
238 schema:familyName Condat
239 schema:givenName Bertrand
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027346503.62
241 rdf:type schema:Person
242 sg:person.01205632314.02 schema:affiliation grid-institutes:grid.411599.1
243 schema:familyName Boudaoud
244 schema:givenName Larbi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205632314.02
246 rdf:type schema:Person
247 sg:person.01231224366.16 schema:affiliation grid-institutes:grid.411599.1
248 schema:familyName Vullierme
249 schema:givenName Marie-Pierre
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231224366.16
251 rdf:type schema:Person
252 sg:person.01351504544.65 schema:affiliation grid-institutes:grid.411599.1
253 schema:familyName Maire
254 schema:givenName Frédérique
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351504544.65
256 rdf:type schema:Person
257 sg:person.01355345644.55 schema:affiliation grid-institutes:grid.411599.1
258 schema:familyName Hammel
259 schema:givenName Pascal
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355345644.55
261 rdf:type schema:Person
262 sg:person.0636012046.73 schema:affiliation grid-institutes:grid.411599.1
263 schema:familyName Vidaud
264 schema:givenName Dominique
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636012046.73
266 rdf:type schema:Person
267 sg:person.0640551545.21 schema:affiliation grid-institutes:grid.411599.1
268 schema:familyName Ruszniewski
269 schema:givenName Philippe
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640551545.21
271 rdf:type schema:Person
272 sg:person.0736275266.26 schema:affiliation grid-institutes:grid.411599.1
273 schema:familyName Hentic
274 schema:givenName Olivia
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736275266.26
276 rdf:type schema:Person
277 sg:person.0740232450.15 schema:affiliation grid-institutes:grid.411599.1
278 schema:familyName Lévy
279 schema:givenName Philippe
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740232450.15
281 rdf:type schema:Person
282 sg:pub.10.1007/bf01307725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019659676
283 https://doi.org/10.1007/bf01307725
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00268-003-7247-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049727592
286 https://doi.org/10.1007/s00268-003-7247-6
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/369064a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024264501
289 https://doi.org/10.1038/369064a0
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.leu.2404069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051453814
292 https://doi.org/10.1038/sj.leu.2404069
293 rdf:type schema:CreativeWork
294 grid-institutes:grid.411599.1 schema:alternateName Pôle de Biologie, d’Imagerie, de Pathologie et de Pharmacie, Service de Biochimie et de génétique, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
295 Pôle de Biologie, d’Imagerie, de Pathologie et de Pharmacie, Service de Radiologie, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
296 Pôle de Biologie, d’Imagerie, de Pathologie et de Pharmacie, Service d’Hématologie et d’Hémostase biologique, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
297 Pôle des Maladies de l’Appareil Digestif, Service de Gastroentérologie–Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Université Paris-Diderot, Clichy, France
298 Pôle des Maladies de l’Appareil Digestif, Service d’Hépatologie, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
299 schema:name Pôle de Biologie, d’Imagerie, de Pathologie et de Pharmacie, Service de Biochimie et de génétique, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
300 Pôle de Biologie, d’Imagerie, de Pathologie et de Pharmacie, Service de Radiologie, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
301 Pôle de Biologie, d’Imagerie, de Pathologie et de Pharmacie, Service d’Hématologie et d’Hémostase biologique, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
302 Pôle des Maladies de l’Appareil Digestif, Service de Gastroentérologie–Pancréatologie, Hôpital Beaujon, AP-HP, Clichy, Inserm U773-CRB3, Université Paris-Diderot, Clichy, France
303 Pôle des Maladies de l’Appareil Digestif, Service d’Hépatologie, Hôpital Beaujon, AP-HP, Clichy, Université Paris-Diderot, Clichy, France
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...