Pancreas Divisum Is Not a Cause of Pancreatitis by Itself But Acts as a Partner of Genetic Mutations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12-13

AUTHORS

Caroline Bertin, Anne-Laure Pelletier, Marie Pierre Vullierme, Thierry Bienvenu, Vinciane Rebours, Olivia Hentic, Frédérique Maire, Pascal Hammel, Valérie Vilgrain, Philippe Ruszniewski, Philippe Lévy

ABSTRACT

OBJECTIVES: The role of pancreas divisum (PD) as a cause of acute recurrent or chronic pancreatitis (AR/CP) is still a matter of debate. METHODS: The aims of this study were to evaluate the frequency of PD diagnosed using magnetic resonance cholangiopancreatography (MRCP) in patients with AR/CP of unknown origin (n=40) after careful exclusion of all known causes and to test the hypothesis of an interaction between anatomical (PD) and functional genetic anomalies (SPINK1, PRSS1, or CFTR gene mutations or polymorphisms (n=19, 25, and 30, respectively)) that could result in AR/CP. Patients with alcohol-induced pancreatitis (n=29) and subjects who had MRCP for a nonpancreatic disease (n=45) served as controls. RESULTS: PD frequency was 7% in subjects without pancreatic disease, 7% in patients with alcohol-induced pancreatitis, and 5, 16, 16, and 47% in those with idiopathic, and PRSS1-, SPINK1-, and CFTR-associated pancreatitis, respectively (P<0.0001). There was no significant difference between idiopathic pancreatitis and the two control groups. The frequency of PD was higher in patients with CFTR gene-associated pancreatitis as compared with those with idiopathic and alcoholic pancreatitis (P<0.0001) and with those with SPINK1 and PRSS1 gene-associated pancreatitis (P<0.02). CONCLUSIONS: The frequency of PD was not different in patients with idiopathic pancreatitis as compared with controls, demonstrating that PD by itself is not a cause of pancreatitis. PD frequency was higher in patients with genetic pancreatitis, especially in those with CFTR mutations or polymorphisms, suggesting a cumulative effect of these two cofactors. More... »

PAGES

ajg2011424

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ajg.2011.424

DOI

http://dx.doi.org/10.1038/ajg.2011.424

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015962213

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22158025


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28 schema:description OBJECTIVES: The role of pancreas divisum (PD) as a cause of acute recurrent or chronic pancreatitis (AR/CP) is still a matter of debate. METHODS: The aims of this study were to evaluate the frequency of PD diagnosed using magnetic resonance cholangiopancreatography (MRCP) in patients with AR/CP of unknown origin (n=40) after careful exclusion of all known causes and to test the hypothesis of an interaction between anatomical (PD) and functional genetic anomalies (SPINK1, PRSS1, or CFTR gene mutations or polymorphisms (n=19, 25, and 30, respectively)) that could result in AR/CP. Patients with alcohol-induced pancreatitis (n=29) and subjects who had MRCP for a nonpancreatic disease (n=45) served as controls. RESULTS: PD frequency was 7% in subjects without pancreatic disease, 7% in patients with alcohol-induced pancreatitis, and 5, 16, 16, and 47% in those with idiopathic, and PRSS1-, SPINK1-, and CFTR-associated pancreatitis, respectively (P<0.0001). There was no significant difference between idiopathic pancreatitis and the two control groups. The frequency of PD was higher in patients with CFTR gene-associated pancreatitis as compared with those with idiopathic and alcoholic pancreatitis (P<0.0001) and with those with SPINK1 and PRSS1 gene-associated pancreatitis (P<0.02). CONCLUSIONS: The frequency of PD was not different in patients with idiopathic pancreatitis as compared with controls, demonstrating that PD by itself is not a cause of pancreatitis. PD frequency was higher in patients with genetic pancreatitis, especially in those with CFTR mutations or polymorphisms, suggesting a cumulative effect of these two cofactors.
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36 CFTR
37 CFTR gene-associated pancreatitis
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39 CP
40 PD frequency
41 PRSS1
42 PRSS1 gene-associated pancreatitis
43 SPINK1
44 act
45 acute recurrent
46 aim
47 alcohol-induced pancreatitis
48 alcoholic pancreatitis
49 anomalies
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51 cause
52 cause of pancreatitis
53 cholangiopancreatography
54 chronic pancreatitis
55 cofactor
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58 cumulative effect
59 debate
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61 disease
62 divisum
63 effect
64 exclusion
65 frequency
66 frequency of PD
67 functional genetic anomalies
68 gene-associated pancreatitis
69 genetic anomalies
70 genetic mutations
71 genetic pancreatitis
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73 hypothesis
74 idiopathic pancreatitis
75 interaction
76 magnetic resonance cholangiopancreatography
77 matter
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79 mutations
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84 pancreatitis
85 partners
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