Outcome Following Infliximab Therapy in Children With Ulcerative Colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-06

AUTHORS

Jeffrey S Hyams, Trudy Lerer, Anne Griffiths, Marian Pfefferkorn, Michael Stephens, Jonathan Evans, Anthony Otley, Ryan Carvalho, David Mack, Athos Bousvaros, Joel Rosh, Andrew Grossman, Gitit Tomer, Marsha Kay, Wallace Crandall, Maria Oliva-Hemker, David Keljo, Neal LeLeiko, James Markowitz

ABSTRACT

OBJECTIVES: Infliximab is effective in treating moderate/severe ulcerative colitis (UC) in adults. The aim of this study was to determine the outcome after treatment with infliximab in pediatric UC. METHODS: We performed a multicenter cohort study of 332 pediatric patients with UC enrolled in the Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry. Children12 months). Mean age at infliximab initiation was 13.3+/-2.6 (range 6-17) years; 87% of patients had pancolitis. Median follow-up was 30 months. Continuous maintenance (CM) therapy was given in 65%, episodic in 21%, episodic converted to CM in 6%, and insufficient data in 8% of patients. Sixty-three percent of patients were corticosteroid refractory, and 35% were corticosteroid dependent. Concomitant medications at first infliximab infusion included corticosteroids (87%), thiopurines (63%), and 5-aminosalicylates (51%). Corticosteroid-free inactive disease by physician global assessment was noted in 12/44 (27%), 15/39 (38%), and 6/28 (21%) patients at 6, 12, and 24 months, respectively. Kaplan-Meier analysis showed that the likelihood of remaining colectomy free after treatment with infliximab was 75% at 6 months, 72% at 12 months, and 61% at 2 years. CONCLUSIONS: In this cohort of children with UC receiving infliximab, corticosteroid-free inactive disease was observed in 38 and 21% of patients at 12 and 24 months, respectively. By 24 months, 61% of patients had avoided colectomy. More... »

PAGES

1430

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ajg.2009.759

DOI

http://dx.doi.org/10.1038/ajg.2009.759

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028870435

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20104217


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