Differences in Genetic Background Between Active Smokers, Passive Smokers, and Non-Smokers With Crohn's Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-01

AUTHORS

Frans van der Heide, Ilja M Nolte, Jan H Kleibeuker, Cisca Wijmenga, Gerard Dijkstra, Rinse K Weersma

ABSTRACT

OBJECTIVES: Smoking behavior and genetic variations are important factors for the development of Crohn's disease (CD), but studies investigating the interaction between smoking and genetic background are scarce. We studied allelic associations of 19 confirmed variants located in 14 CD-associated genes or loci, in CD patients stratified for active smoking at diagnosis and passive smoking in childhood. METHODS: Genotyping data of 19 CD-associated single-nucleotide polymorphisms (SNPs) were available for 310 CD patients and 976 controls. Data on active smoking at diagnosis and passive smoking in childhood were obtained through a written questionnaire and a review of medical charts. RESULTS: The loci associated in smoking, but not in non-smoking, CD patients were 5p13.1 (rs17234657), DLG5 (rs2165047), NKX2-3 (rs10883365), and NOD2 (R702W). The loci associated in non-smoking, but not in smoking, CD patients were IL23R (rs7517847), 5p13.1 (rs9292777), IRGM (rs13361189 and rs4958847), IL12B (rs6887695), and CCNY (rs3936503). PTPN2 (rs2542151) was only associated in the smoking CD cohort (P=0.041), and not in the entire cohort (P=0.23) or in the non-smoking CD cohort (P=0.80). In passively smoking CD patients, associations with 13 SNPs in 9 loci were found, including PTPN2. In non-passive smoking CD patients, only associations with NOD2 (1007fsinsC and G908R) were found. CONCLUSIONS: The difference in associated genes between smoking and non-smoking CD patients implies a complex gene-environment interaction. Therefore, genetic studies of CD should be stratified for smoking behavior, as otherwise moderately associated genes such as PTPN2 can be missed. More... »

PAGES

1165

References to SciGraph publications

  • 2008-05-07. Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking in ARTHRITIS RESEARCH & THERAPY
  • 1992-07. Maternal-child blood group incompatibility and other perinatal events increase the risk for early-onset type 1 (insulin-dependent) diabetes mellitus in DIABETOLOGIA
  • 2007-06. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2008-06-29. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease in NATURE GENETICS
  • 1989-12. A meta-analysis of the role of smoking in inflammatory bowel disease in DIGESTIVE DISEASES AND SCIENCES
  • 2007-11-28. ATG16L1 and IL23R Are Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2001-05. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease in NATURE
  • 2001-05. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease in NATURE
  • 2005-05. Early childhood risk factors associated with type 1 diabetes – is gender important? in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2006-11-13. A Population-Based Case-Control Study of CARD15 and Other Risk Factors in Crohn's Disease and Ulcerative Colitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-01-27. Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ajg.2009.659

    DOI

    http://dx.doi.org/10.1038/ajg.2009.659

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044821578

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19953089


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Age Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alleles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Confidence Intervals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crohn Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Incidence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-12 Subunit p40", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Probability", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Tyrosine Phosphatase, Non-Receptor Type 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reference Values", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Assessment", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Smoking", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Statistics, Nonparametric", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tobacco Smoke Pollution", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Heide", 
            "givenName": "Frans", 
            "id": "sg:person.01236675472.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236675472.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nolte", 
            "givenName": "Ilja M", 
            "id": "sg:person.01316742644.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316742644.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kleibeuker", 
            "givenName": "Jan H", 
            "id": "sg:person.016456356257.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016456356257.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medical Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Department of Medical Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wijmenga", 
            "givenName": "Cisca", 
            "id": "sg:person.01372510466.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372510466.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dijkstra", 
            "givenName": "Gerard", 
            "id": "sg:person.0600470137.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600470137.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.4830.f", 
              "name": [
                "Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weersma", 
            "givenName": "Rinse K", 
            "id": "sg:person.01346343347.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346343347.18"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1111/j.1572-0241.2006.00926.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006636141", 
              "https://doi.org/10.1111/j.1572-0241.2006.00926.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035894615", 
              "https://doi.org/10.1038/ng.175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2008.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014606926", 
              "https://doi.org/10.1038/ajg.2008.112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar2421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040542385", 
              "https://doi.org/10.1186/ar2421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01536701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028088201", 
              "https://doi.org/10.1007/bf01536701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031360950", 
              "https://doi.org/10.1038/35079107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35079114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030806509", 
              "https://doi.org/10.1038/35079114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2007.01660.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008814014", 
              "https://doi.org/10.1111/j.1572-0241.2007.01660.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004556449", 
              "https://doi.org/10.1038/nature05911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00400261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050734400", 
              "https://doi.org/10.1007/bf00400261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-005-0878-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017045915", 
              "https://doi.org/10.1007/s10654-005-0878-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-12-01", 
        "datePublishedReg": "2009-12-01", 
        "description": "OBJECTIVES: Smoking behavior and genetic variations are important factors for the development of Crohn's disease (CD), but studies investigating the interaction between smoking and genetic background are scarce. We studied allelic associations of 19 confirmed variants located in 14 CD-associated genes or loci, in CD patients stratified for active smoking at diagnosis and passive smoking in childhood.\nMETHODS: Genotyping data of 19 CD-associated single-nucleotide polymorphisms (SNPs) were available for 310 CD patients and 976 controls. Data on active smoking at diagnosis and passive smoking in childhood were obtained through a written questionnaire and a review of medical charts.\nRESULTS: The loci associated in smoking, but not in non-smoking, CD patients were 5p13.1 (rs17234657), DLG5 (rs2165047), NKX2-3 (rs10883365), and NOD2 (R702W). The loci associated in non-smoking, but not in smoking, CD patients were IL23R (rs7517847), 5p13.1 (rs9292777), IRGM (rs13361189 and rs4958847), IL12B (rs6887695), and CCNY (rs3936503). PTPN2 (rs2542151) was only associated in the smoking CD cohort (P=0.041), and not in the entire cohort (P=0.23) or in the non-smoking CD cohort (P=0.80). In passively smoking CD patients, associations with 13 SNPs in 9 loci were found, including PTPN2. In non-passive smoking CD patients, only associations with NOD2 (1007fsinsC and G908R) were found.\nCONCLUSIONS: The difference in associated genes between smoking and non-smoking CD patients implies a complex gene-environment interaction. Therefore, genetic studies of CD should be stratified for smoking behavior, as otherwise moderately associated genes such as PTPN2 can be missed.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ajg.2009.659", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1412991", 
            "issn": [
              "0002-9270", 
              "1572-0241"
            ], 
            "name": "The American Journal of Gastroenterology", 
            "publisher": "Wolters Kluwer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "105"
          }
        ], 
        "keywords": [
          "CD patients", 
          "Crohn's disease", 
          "active smoking", 
          "passive smoking", 
          "CD cohort", 
          "smoking behavior", 
          "single nucleotide polymorphisms", 
          "CD-associated single nucleotide polymorphisms", 
          "CD-associated genes", 
          "complex gene-environment interactions", 
          "medical charts", 
          "active smokers", 
          "passive smokers", 
          "entire cohort", 
          "smoking", 
          "patients", 
          "gene-environment interactions", 
          "genetic background", 
          "disease", 
          "cohort", 
          "NKX2-3", 
          "smokers", 
          "NOD2", 
          "PTPN2", 
          "diagnosis", 
          "association", 
          "childhood", 
          "allelic association", 
          "IRGM", 
          "IL12B", 
          "genetic studies", 
          "genes", 
          "differences", 
          "study", 
          "questionnaire", 
          "DLG5", 
          "background", 
          "important factor", 
          "polymorphism", 
          "review", 
          "charts", 
          "factors", 
          "data", 
          "genetic variation", 
          "control", 
          "variants", 
          "loci", 
          "CCNY", 
          "development", 
          "interaction", 
          "behavior", 
          "variation"
        ], 
        "name": "Differences in Genetic Background Between Active Smokers, Passive Smokers, and Non-Smokers With Crohn's Disease", 
        "pagination": "1165", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044821578"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ajg.2009.659"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19953089"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ajg.2009.659", 
          "https://app.dimensions.ai/details/publication/pub.1044821578"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:54", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_492.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ajg.2009.659"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.659'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.659'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.659'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.659'


     

    This table displays all metadata directly associated to this object as RDF triples.

    312 TRIPLES      21 PREDICATES      117 URIs      98 LITERALS      36 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ajg.2009.659 schema:about N0c284d2a77b84bd687e2f6dedab6cc2c
    2 N12bbbdf5f9e641b1970949b07fbd5ccf
    3 N16929319aad04378a47b0bdaee0c7d96
    4 N17498f97fe7a4c4a994778ed9be7f346
    5 N1e9405902fac48969bd336d025b25d3f
    6 N2311f5d85922428b9f89d87124b20d91
    7 N248af75e0c334762a224292a37e46131
    8 N2de7e763c8b64730a100df3fe9c6e50d
    9 N3094f65037854579ae2d397a48ae52ed
    10 N43df121e315f4e30bcecec6a33824b56
    11 N4bfd48eff5b148b9b63613a1bd5643ef
    12 N7304d1d1b298451fa6ec2ebdaff9ba27
    13 N738cfa2ae5dc4aa798162bc0562c86f6
    14 N7a7f793901aa4668b9e4b574e61850f0
    15 N7aded6d59af44ab589afd9f60b744733
    16 N7ee3b6d7f0d945509d096ffb7fcf22b0
    17 N8e6ca4c6a70f4b3ea57e7dd07ee8b2b7
    18 N954ccdf2fd96492283fe0b3c72fba9a1
    19 N9f53370439994b1995bd86afb87c8ced
    20 Na5f026cfed8948ccbbeea5b84efd1e0c
    21 Nad1e52f74df743c5ba645867e68ac328
    22 Nc2a6dddce2844ebb88060c55e8a8a6b1
    23 Nc5d7788a278c46b9a7fd5e1ac93071a3
    24 Nc83d69b74ee3492eb43e1001810d796f
    25 Nc8532df80b214d0a9a40e4e8abc3abaf
    26 Ne07e35914ca44b418e822759cb4a006f
    27 Ne59a4bafc50848f8af6c6e9916a43d43
    28 Ne90c645f2908488bb0676af86523d4a2
    29 Nf7d2f14297db424eb848c0a8fca9713f
    30 anzsrc-for:11
    31 anzsrc-for:1103
    32 schema:author N35cf6cf0c4604ff893d191c36648d8b6
    33 schema:citation sg:pub.10.1007/bf00400261
    34 sg:pub.10.1007/bf01536701
    35 sg:pub.10.1007/s10654-005-0878-1
    36 sg:pub.10.1038/35079107
    37 sg:pub.10.1038/35079114
    38 sg:pub.10.1038/ajg.2008.112
    39 sg:pub.10.1038/nature05911
    40 sg:pub.10.1038/ng.175
    41 sg:pub.10.1111/j.1572-0241.2006.00926.x
    42 sg:pub.10.1111/j.1572-0241.2007.01660.x
    43 sg:pub.10.1186/ar2421
    44 schema:datePublished 2009-12-01
    45 schema:datePublishedReg 2009-12-01
    46 schema:description OBJECTIVES: Smoking behavior and genetic variations are important factors for the development of Crohn's disease (CD), but studies investigating the interaction between smoking and genetic background are scarce. We studied allelic associations of 19 confirmed variants located in 14 CD-associated genes or loci, in CD patients stratified for active smoking at diagnosis and passive smoking in childhood. METHODS: Genotyping data of 19 CD-associated single-nucleotide polymorphisms (SNPs) were available for 310 CD patients and 976 controls. Data on active smoking at diagnosis and passive smoking in childhood were obtained through a written questionnaire and a review of medical charts. RESULTS: The loci associated in smoking, but not in non-smoking, CD patients were 5p13.1 (rs17234657), DLG5 (rs2165047), NKX2-3 (rs10883365), and NOD2 (R702W). The loci associated in non-smoking, but not in smoking, CD patients were IL23R (rs7517847), 5p13.1 (rs9292777), IRGM (rs13361189 and rs4958847), IL12B (rs6887695), and CCNY (rs3936503). PTPN2 (rs2542151) was only associated in the smoking CD cohort (P=0.041), and not in the entire cohort (P=0.23) or in the non-smoking CD cohort (P=0.80). In passively smoking CD patients, associations with 13 SNPs in 9 loci were found, including PTPN2. In non-passive smoking CD patients, only associations with NOD2 (1007fsinsC and G908R) were found. CONCLUSIONS: The difference in associated genes between smoking and non-smoking CD patients implies a complex gene-environment interaction. Therefore, genetic studies of CD should be stratified for smoking behavior, as otherwise moderately associated genes such as PTPN2 can be missed.
    47 schema:genre article
    48 schema:isAccessibleForFree false
    49 schema:isPartOf N7682ec10d16c4972b699e1cf0d988658
    50 Nfbae9308ad3a48739c18ffd3a107cce0
    51 sg:journal.1412991
    52 schema:keywords CCNY
    53 CD cohort
    54 CD patients
    55 CD-associated genes
    56 CD-associated single nucleotide polymorphisms
    57 Crohn's disease
    58 DLG5
    59 IL12B
    60 IRGM
    61 NKX2-3
    62 NOD2
    63 PTPN2
    64 active smokers
    65 active smoking
    66 allelic association
    67 association
    68 background
    69 behavior
    70 charts
    71 childhood
    72 cohort
    73 complex gene-environment interactions
    74 control
    75 data
    76 development
    77 diagnosis
    78 differences
    79 disease
    80 entire cohort
    81 factors
    82 gene-environment interactions
    83 genes
    84 genetic background
    85 genetic studies
    86 genetic variation
    87 important factor
    88 interaction
    89 loci
    90 medical charts
    91 passive smokers
    92 passive smoking
    93 patients
    94 polymorphism
    95 questionnaire
    96 review
    97 single nucleotide polymorphisms
    98 smokers
    99 smoking
    100 smoking behavior
    101 study
    102 variants
    103 variation
    104 schema:name Differences in Genetic Background Between Active Smokers, Passive Smokers, and Non-Smokers With Crohn's Disease
    105 schema:pagination 1165
    106 schema:productId N1e0aeac219b8431cb16c24ba7bdfb9b0
    107 N70e4292eeca44dbb8d6dff577680762c
    108 Nba155f5857fd461cb72becfbfb0ff0af
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044821578
    110 https://doi.org/10.1038/ajg.2009.659
    111 schema:sdDatePublished 2022-11-24T20:54
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher Nff5a2c274f324a54802ce2be619e37f8
    114 schema:url https://doi.org/10.1038/ajg.2009.659
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N0c284d2a77b84bd687e2f6dedab6cc2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Tobacco Smoke Pollution
    120 rdf:type schema:DefinedTerm
    121 N12bbbdf5f9e641b1970949b07fbd5ccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Probability
    123 rdf:type schema:DefinedTerm
    124 N16929319aad04378a47b0bdaee0c7d96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Alleles
    126 rdf:type schema:DefinedTerm
    127 N17498f97fe7a4c4a994778ed9be7f346 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Young Adult
    129 rdf:type schema:DefinedTerm
    130 N1e0aeac219b8431cb16c24ba7bdfb9b0 schema:name dimensions_id
    131 schema:value pub.1044821578
    132 rdf:type schema:PropertyValue
    133 N1e9405902fac48969bd336d025b25d3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Humans
    135 rdf:type schema:DefinedTerm
    136 N2311f5d85922428b9f89d87124b20d91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Genome-Wide Association Study
    138 rdf:type schema:DefinedTerm
    139 N248af75e0c334762a224292a37e46131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Age Factors
    141 rdf:type schema:DefinedTerm
    142 N2de7e763c8b64730a100df3fe9c6e50d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Middle Aged
    144 rdf:type schema:DefinedTerm
    145 N3094f65037854579ae2d397a48ae52ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Interleukin-12 Subunit p40
    147 rdf:type schema:DefinedTerm
    148 N35cf6cf0c4604ff893d191c36648d8b6 rdf:first sg:person.01236675472.96
    149 rdf:rest N8c0dca4cee864947b6e93ee1873cf8d1
    150 N43df121e315f4e30bcecec6a33824b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Risk Assessment
    152 rdf:type schema:DefinedTerm
    153 N4bfd48eff5b148b9b63613a1bd5643ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Adult
    155 rdf:type schema:DefinedTerm
    156 N70e4292eeca44dbb8d6dff577680762c schema:name doi
    157 schema:value 10.1038/ajg.2009.659
    158 rdf:type schema:PropertyValue
    159 N7304d1d1b298451fa6ec2ebdaff9ba27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Genetic Predisposition to Disease
    161 rdf:type schema:DefinedTerm
    162 N738cfa2ae5dc4aa798162bc0562c86f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Aged
    164 rdf:type schema:DefinedTerm
    165 N7682ec10d16c4972b699e1cf0d988658 schema:volumeNumber 105
    166 rdf:type schema:PublicationVolume
    167 N7a7f793901aa4668b9e4b574e61850f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Protein Tyrosine Phosphatase, Non-Receptor Type 2
    169 rdf:type schema:DefinedTerm
    170 N7aded6d59af44ab589afd9f60b744733 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Tumor Suppressor Proteins
    172 rdf:type schema:DefinedTerm
    173 N7ee3b6d7f0d945509d096ffb7fcf22b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Smoking
    175 rdf:type schema:DefinedTerm
    176 N8b17f1309bed4e189c0a898651f33568 rdf:first sg:person.01346343347.18
    177 rdf:rest rdf:nil
    178 N8c0dca4cee864947b6e93ee1873cf8d1 rdf:first sg:person.01316742644.30
    179 rdf:rest N9bd7a9cd0221444fa8a4e19162e6f421
    180 N8e6ca4c6a70f4b3ea57e7dd07ee8b2b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Follow-Up Studies
    182 rdf:type schema:DefinedTerm
    183 N954ccdf2fd96492283fe0b3c72fba9a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Cohort Studies
    185 rdf:type schema:DefinedTerm
    186 N9bd7a9cd0221444fa8a4e19162e6f421 rdf:first sg:person.016456356257.18
    187 rdf:rest Nfb4225ff06f74d34a252ff8d4914550b
    188 N9f53370439994b1995bd86afb87c8ced schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Incidence
    190 rdf:type schema:DefinedTerm
    191 Na5f026cfed8948ccbbeea5b84efd1e0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Membrane Proteins
    193 rdf:type schema:DefinedTerm
    194 Nad1e52f74df743c5ba645867e68ac328 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Adolescent
    196 rdf:type schema:DefinedTerm
    197 Nb5345a54774545a0b7d50177a7c78274 rdf:first sg:person.0600470137.03
    198 rdf:rest N8b17f1309bed4e189c0a898651f33568
    199 Nba155f5857fd461cb72becfbfb0ff0af schema:name pubmed_id
    200 schema:value 19953089
    201 rdf:type schema:PropertyValue
    202 Nc2a6dddce2844ebb88060c55e8a8a6b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Confidence Intervals
    204 rdf:type schema:DefinedTerm
    205 Nc5d7788a278c46b9a7fd5e1ac93071a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Male
    207 rdf:type schema:DefinedTerm
    208 Nc83d69b74ee3492eb43e1001810d796f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Crohn Disease
    210 rdf:type schema:DefinedTerm
    211 Nc8532df80b214d0a9a40e4e8abc3abaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Reference Values
    213 rdf:type schema:DefinedTerm
    214 Ne07e35914ca44b418e822759cb4a006f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Sex Factors
    216 rdf:type schema:DefinedTerm
    217 Ne59a4bafc50848f8af6c6e9916a43d43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Statistics, Nonparametric
    219 rdf:type schema:DefinedTerm
    220 Ne90c645f2908488bb0676af86523d4a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Polymorphism, Single Nucleotide
    222 rdf:type schema:DefinedTerm
    223 Nf7d2f14297db424eb848c0a8fca9713f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Female
    225 rdf:type schema:DefinedTerm
    226 Nfb4225ff06f74d34a252ff8d4914550b rdf:first sg:person.01372510466.28
    227 rdf:rest Nb5345a54774545a0b7d50177a7c78274
    228 Nfbae9308ad3a48739c18ffd3a107cce0 schema:issueNumber 5
    229 rdf:type schema:PublicationIssue
    230 Nff5a2c274f324a54802ce2be619e37f8 schema:name Springer Nature - SN SciGraph project
    231 rdf:type schema:Organization
    232 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Medical and Health Sciences
    234 rdf:type schema:DefinedTerm
    235 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    236 schema:name Clinical Sciences
    237 rdf:type schema:DefinedTerm
    238 sg:journal.1412991 schema:issn 0002-9270
    239 1572-0241
    240 schema:name The American Journal of Gastroenterology
    241 schema:publisher Wolters Kluwer
    242 rdf:type schema:Periodical
    243 sg:person.01236675472.96 schema:affiliation grid-institutes:grid.4830.f
    244 schema:familyName van der Heide
    245 schema:givenName Frans
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236675472.96
    247 rdf:type schema:Person
    248 sg:person.01316742644.30 schema:affiliation grid-institutes:grid.4830.f
    249 schema:familyName Nolte
    250 schema:givenName Ilja M
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316742644.30
    252 rdf:type schema:Person
    253 sg:person.01346343347.18 schema:affiliation grid-institutes:grid.4830.f
    254 schema:familyName Weersma
    255 schema:givenName Rinse K
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346343347.18
    257 rdf:type schema:Person
    258 sg:person.01372510466.28 schema:affiliation grid-institutes:grid.4830.f
    259 schema:familyName Wijmenga
    260 schema:givenName Cisca
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372510466.28
    262 rdf:type schema:Person
    263 sg:person.016456356257.18 schema:affiliation grid-institutes:grid.4830.f
    264 schema:familyName Kleibeuker
    265 schema:givenName Jan H
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016456356257.18
    267 rdf:type schema:Person
    268 sg:person.0600470137.03 schema:affiliation grid-institutes:grid.4830.f
    269 schema:familyName Dijkstra
    270 schema:givenName Gerard
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600470137.03
    272 rdf:type schema:Person
    273 sg:pub.10.1007/bf00400261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050734400
    274 https://doi.org/10.1007/bf00400261
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1007/bf01536701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028088201
    277 https://doi.org/10.1007/bf01536701
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1007/s10654-005-0878-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017045915
    280 https://doi.org/10.1007/s10654-005-0878-1
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
    283 https://doi.org/10.1038/35079107
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/35079114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030806509
    286 https://doi.org/10.1038/35079114
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/ajg.2008.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014606926
    289 https://doi.org/10.1038/ajg.2008.112
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/nature05911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004556449
    292 https://doi.org/10.1038/nature05911
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/ng.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035894615
    295 https://doi.org/10.1038/ng.175
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1111/j.1572-0241.2006.00926.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006636141
    298 https://doi.org/10.1111/j.1572-0241.2006.00926.x
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1111/j.1572-0241.2007.01660.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008814014
    301 https://doi.org/10.1111/j.1572-0241.2007.01660.x
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1186/ar2421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040542385
    304 https://doi.org/10.1186/ar2421
    305 rdf:type schema:CreativeWork
    306 grid-institutes:grid.4830.f schema:alternateName Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    307 Department of Medical Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    308 Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    309 schema:name Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    310 Department of Medical Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    311 Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    312 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...