An Open-Label Prospective Randomized Multicenter Study Shows Very Rapid Remission of Ulcerative Colitis by Intensive Granulocyte and Monocyte Adsorptive Apheresis ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09-01

AUTHORS

Atsushi Sakuraba, Satoshi Motoya, Kenji Watanabe, Masakazu Nishishita, Kazunari Kanke, Toshiyuki Matsui, Yasuo Suzuki, Tadayuki Oshima, Reiko Kunisaki, Takayuki Matsumoto, Hiroyuki Hanai, Ken Fukunaga, Naoki Yoshimura, Toshimi Chiba, Shinsuke Funakoshi, Nobuo Aoyama, Akira Andoh, Hiroshi Nakase, Yohei Mizuta, Ryoichi Suzuki, Taiji Akamatsu, Masahiro Iizuka, Toshifumi Ashida, Toshifumi Hibi

ABSTRACT

OBJECTIVES: Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active ulcerative colitis (UC). However, with routine weekly treatment, it may take several weeks to achieve remission, and to date, the efficacy of a more frequent treatment schedule remains unknown. The aim of this study was to assess the clinical efficacy and safety of intensive GMA treatment in patients with active UC. METHODS: This was an open-label, prospective, randomized multicenter study to compare an intensive, two GMA sessions per week, with the routine, one GMA session per week. A total of 163 patients with mild-to-moderately active UC were randomly assigned to routine weekly treatment or intensive treatment. The maximum number of sessions of GMA permitted was 10. However, when patients achieved remission, GMA was discontinued. Remission rate at the end of the study, time to remission, and adverse events were assessed in both groups. RESULTS: Of the 163 patients, 149 were available for efficacy analysis as per protocol, 76 were in weekly GMA, and 73 were in intensive GMA. At the end of the study period, clinical remission was achieved in 41 of 76 patients (54.0%) in weekly GMA and in 52 of 73 patients (71.2%) in intensive GMA (P=0.029). The mean time to remission was 28.1+/-16.9 days in the weekly GMA treatment group and 14.9+/-9.5 days in the intensive GMA group (P<0.0001). Intensive GMA was well tolerated without GMA-related serious adverse side effects. CONCLUSIONS: Intensive GMA in patients with active UC seems to be more efficacious than weekly treatment, and significantly reduced the patients' morbidity time without increasing the incidence of side effects. More... »

PAGES

ajg2009453

Journal

TITLE

The American Journal of Gastroenterology

ISSUE

12

VOLUME

104

Author Affiliations

  • Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
  • Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan
  • Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
  • Nishishita Intestinal Hospital, Osaka, Japan
  • Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan
  • Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
  • Department of Internal Medicine, Sakura Hospital, Toho University, Sakura, Japan
  • Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  • Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
  • Department of Internal Medicine, Kyusyu University, Fukuoka, Japan
  • Kakegawa North Hospital, Kakegawa, Japan
  • Department of Gastroenterology, Hyogo College of Medicine, Hyougo, Japan
  • Department of Internal Medicine, Chiba University, Chiba, Japan
  • The First Department of Internal Medicine, Iwate Medical University School of Medicine, Masoka, Japan
  • Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
  • Department of Endoscopy, Kobe University School of Medicine, Kobe, Japan
  • Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
  • Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • Department of Internal Medicine, Nagasaki University, Nagasaki, Japan
  • Kannai Suzuki Clinic, Yokohama, Japan
  • Division of Gastroenterology, The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
  • The First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
  • The Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ajg.2009.453

    DOI

    http://dx.doi.org/10.1038/ajg.2009.453

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014082600

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19724269


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adsorption", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Component Removal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colitis, Ulcerative", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Granulocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Monocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Remission Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Statistics, Nonparametric", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakuraba", 
            "givenName": "Atsushi", 
            "id": "sg:person.01153677003.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153677003.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415268.c", 
              "name": [
                "Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Motoya", 
            "givenName": "Satoshi", 
            "id": "sg:person.01233507634.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233507634.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.261445.0", 
              "name": [
                "Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Kenji", 
            "id": "sg:person.01363432737.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363432737.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Nishishita Intestinal Hospital, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Nishishita Intestinal Hospital, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishishita", 
            "givenName": "Masakazu", 
            "id": "sg:person.01070757373.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070757373.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan", 
              "id": "http://www.grid.ac/institutes/grid.255137.7", 
              "name": [
                "Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanke", 
            "givenName": "Kazunari", 
            "id": "sg:person.0610313122.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610313122.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411556.2", 
              "name": [
                "Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsui", 
            "givenName": "Toshiyuki", 
            "id": "sg:person.014575262532.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014575262532.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Sakura Hospital, Toho University, Sakura, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265050.4", 
              "name": [
                "Department of Internal Medicine, Sakura Hospital, Toho University, Sakura, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Yasuo", 
            "id": "sg:person.011447440744.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011447440744.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.260433.0", 
              "name": [
                "Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oshima", 
            "givenName": "Tadayuki", 
            "id": "sg:person.0723101126.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723101126.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413045.7", 
              "name": [
                "Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kunisaki", 
            "givenName": "Reiko", 
            "id": "sg:person.0671355412.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671355412.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Kyusyu University, Fukuoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.177174.3", 
              "name": [
                "Department of Internal Medicine, Kyusyu University, Fukuoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsumoto", 
            "givenName": "Takayuki", 
            "id": "sg:person.012162205442.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kakegawa North Hospital, Kakegawa, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Kakegawa North Hospital, Kakegawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanai", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.01160277320.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160277320.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Hyogo College of Medicine, Hyougo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Department of Gastroenterology, Hyogo College of Medicine, Hyougo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukunaga", 
            "givenName": "Ken", 
            "id": "sg:person.0627440023.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627440023.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Chiba University, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of Internal Medicine, Chiba University, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshimura", 
            "givenName": "Naoki", 
            "id": "sg:person.01215313304.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215313304.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The First Department of Internal Medicine, Iwate Medical University School of Medicine, Masoka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.411790.a", 
              "name": [
                "The First Department of Internal Medicine, Iwate Medical University School of Medicine, Masoka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chiba", 
            "givenName": "Toshimi", 
            "id": "sg:person.0733141344.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733141344.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.415395.f", 
              "name": [
                "Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Funakoshi", 
            "givenName": "Shinsuke", 
            "id": "sg:person.0764046045.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764046045.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Endoscopy, Kobe University School of Medicine, Kobe, Japan", 
              "id": "http://www.grid.ac/institutes/grid.31432.37", 
              "name": [
                "Department of Endoscopy, Kobe University School of Medicine, Kobe, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aoyama", 
            "givenName": "Nobuo", 
            "id": "sg:person.01107367561.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107367561.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andoh", 
            "givenName": "Akira", 
            "id": "sg:person.01075512433.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075512433.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.258799.8", 
              "name": [
                "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakase", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01362225512.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362225512.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Internal Medicine, Nagasaki University, Nagasaki, Japan", 
              "id": "http://www.grid.ac/institutes/grid.174567.6", 
              "name": [
                "Department of Internal Medicine, Nagasaki University, Nagasaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mizuta", 
            "givenName": "Yohei", 
            "id": "sg:person.01335473422.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335473422.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kannai Suzuki Clinic, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Kannai Suzuki Clinic, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Ryoichi", 
            "id": "sg:person.01126763434.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126763434.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology, The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.263518.b", 
              "name": [
                "Division of Gastroenterology, The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akamatsu", 
            "givenName": "Taiji", 
            "id": "sg:person.0651434566.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651434566.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan", 
              "id": "http://www.grid.ac/institutes/grid.251924.9", 
              "name": [
                "The First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iizuka", 
            "givenName": "Masahiro", 
            "id": "sg:person.0634332227.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634332227.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.252427.4", 
              "name": [
                "The Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ashida", 
            "givenName": "Toshifumi", 
            "id": "sg:person.01332254073.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332254073.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hibi", 
            "givenName": "Toshifumi", 
            "id": "sg:person.01146640377.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146640377.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf01296907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044553757", 
              "https://doi.org/10.1007/bf01296907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00290518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014356510", 
              "https://doi.org/10.1007/bf00290518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013517631", 
              "https://doi.org/10.1038/nature06005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00002018-199106030-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022649861", 
              "https://doi.org/10.2165/00002018-199106030-00005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpgasthep0168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045479349", 
              "https://doi.org/10.1038/ncpgasthep0168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-004-1465-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009327356", 
              "https://doi.org/10.1007/s00535-004-1465-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-007-2129-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007758511", 
              "https://doi.org/10.1007/s00535-007-2129-6"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-09-01", 
        "datePublishedReg": "2009-09-01", 
        "description": "OBJECTIVES: Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active ulcerative colitis (UC). However, with routine weekly treatment, it may take several weeks to achieve remission, and to date, the efficacy of a more frequent treatment schedule remains unknown. The aim of this study was to assess the clinical efficacy and safety of intensive GMA treatment in patients with active UC.\nMETHODS: This was an open-label, prospective, randomized multicenter study to compare an intensive, two GMA sessions per week, with the routine, one GMA session per week. A total of 163 patients with mild-to-moderately active UC were randomly assigned to routine weekly treatment or intensive treatment. The maximum number of sessions of GMA permitted was 10. However, when patients achieved remission, GMA was discontinued. Remission rate at the end of the study, time to remission, and adverse events were assessed in both groups.\nRESULTS: Of the 163 patients, 149 were available for efficacy analysis as per protocol, 76 were in weekly GMA, and 73 were in intensive GMA. At the end of the study period, clinical remission was achieved in 41 of 76 patients (54.0%) in weekly GMA and in 52 of 73 patients (71.2%) in intensive GMA (P=0.029). The mean time to remission was 28.1+/-16.9 days in the weekly GMA treatment group and 14.9+/-9.5 days in the intensive GMA group (P<0.0001). Intensive GMA was well tolerated without GMA-related serious adverse side effects.\nCONCLUSIONS: Intensive GMA in patients with active UC seems to be more efficacious than weekly treatment, and significantly reduced the patients' morbidity time without increasing the incidence of side effects.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/ajg.2009.453", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1019809", 
            "issn": [
              "0002-9270", 
              "1572-0241"
            ], 
            "name": "The American Journal of Gastroenterology", 
            "publisher": "Wolters Kluwer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "104"
          }
        ], 
        "keywords": [
          "active ulcerative colitis", 
          "ulcerative colitis", 
          "intensive GMA", 
          "weekly treatment", 
          "adsorptive apheresis", 
          "GMA sessions", 
          "weekly GMA", 
          "multicenter study", 
          "side effects", 
          "Prospective Randomized Multicenter Study", 
          "serious adverse side effects", 
          "monocyte adsorptive apheresis", 
          "randomized multicenter study", 
          "adverse side effects", 
          "intensive granulocyte", 
          "remission rate", 
          "clinical remission", 
          "adverse events", 
          "rapid remission", 
          "clinical efficacy", 
          "efficacy analysis", 
          "GMA treatment", 
          "intensive treatment", 
          "remission", 
          "treatment groups", 
          "treatment schedule", 
          "patients", 
          "study period", 
          "mean time", 
          "weeks", 
          "colitis", 
          "treatment", 
          "efficacy", 
          "apheresis", 
          "granulocytes", 
          "GMA group", 
          "sessions", 
          "group", 
          "days", 
          "study", 
          "mild", 
          "incidence", 
          "total", 
          "safety", 
          "effect", 
          "aim", 
          "schedule", 
          "time", 
          "period", 
          "end", 
          "protocol", 
          "rate", 
          "events", 
          "date", 
          "number", 
          "routines", 
          "maximum number", 
          "analysis", 
          "GMA", 
          "routine weekly treatment", 
          "frequent treatment schedule", 
          "intensive GMA treatment", 
          "weekly GMA treatment group", 
          "GMA treatment group", 
          "intensive GMA group", 
          "patients' morbidity time", 
          "' morbidity time", 
          "Open-Label Prospective Randomized Multicenter Study"
        ], 
        "name": "An Open-Label Prospective Randomized Multicenter Study Shows Very Rapid Remission of Ulcerative Colitis by Intensive Granulocyte and Monocyte Adsorptive Apheresis as Compared With Routine Weekly Treatment", 
        "pagination": "ajg2009453", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1014082600"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ajg.2009.453"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19724269"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ajg.2009.453", 
          "https://app.dimensions.ai/details/publication/pub.1014082600"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_482.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/ajg.2009.453"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.453'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.453'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.453'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ajg.2009.453'


     

    This table displays all metadata directly associated to this object as RDF triples.

    447 TRIPLES      22 PREDICATES      117 URIs      102 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ajg.2009.453 schema:about N0c4ba8eb46d0447a895eccbd25923e51
    2 N335bd894f8454362baf86b99a8f4e829
    3 N4d779b62c9bf4e1099c1be2cadccf4c8
    4 N5ab70390ee83488ea7d14a91d98a1364
    5 N6087a34b2d7946abac158a761dbcbe90
    6 N9ac91959172047a6834779b73c81d116
    7 Nac5b7b2569b945538ea70d9ee39aef83
    8 Nb9a6082564fb49fd9c0efe60f98e4544
    9 Nbc5c716c097243d58fc31f974cec6c81
    10 Nc6fc29265073499e96ef438a092515c5
    11 Nd24448cf8e934282ad9aac518b476bf3
    12 Nd510b47e89084569af5a732cf3b8e9cc
    13 Ne25b610d79f34c4ba521914be749bc99
    14 Ne82b09a8bdee4e338b9083c93d5d206f
    15 Neeff8a9cefe4409eabc9134164c6a3f9
    16 Nfc9a9d9752b5498a888b415870087a55
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author N7ee60b19952e47829c60d532b0be9174
    20 schema:citation sg:pub.10.1007/bf00290518
    21 sg:pub.10.1007/bf01296907
    22 sg:pub.10.1007/s00535-004-1465-z
    23 sg:pub.10.1007/s00535-007-2129-6
    24 sg:pub.10.1038/nature06005
    25 sg:pub.10.1038/ncpgasthep0168
    26 sg:pub.10.2165/00002018-199106030-00005
    27 schema:datePublished 2009-09-01
    28 schema:datePublishedReg 2009-09-01
    29 schema:description OBJECTIVES: Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active ulcerative colitis (UC). However, with routine weekly treatment, it may take several weeks to achieve remission, and to date, the efficacy of a more frequent treatment schedule remains unknown. The aim of this study was to assess the clinical efficacy and safety of intensive GMA treatment in patients with active UC. METHODS: This was an open-label, prospective, randomized multicenter study to compare an intensive, two GMA sessions per week, with the routine, one GMA session per week. A total of 163 patients with mild-to-moderately active UC were randomly assigned to routine weekly treatment or intensive treatment. The maximum number of sessions of GMA permitted was 10. However, when patients achieved remission, GMA was discontinued. Remission rate at the end of the study, time to remission, and adverse events were assessed in both groups. RESULTS: Of the 163 patients, 149 were available for efficacy analysis as per protocol, 76 were in weekly GMA, and 73 were in intensive GMA. At the end of the study period, clinical remission was achieved in 41 of 76 patients (54.0%) in weekly GMA and in 52 of 73 patients (71.2%) in intensive GMA (P=0.029). The mean time to remission was 28.1+/-16.9 days in the weekly GMA treatment group and 14.9+/-9.5 days in the intensive GMA group (P<0.0001). Intensive GMA was well tolerated without GMA-related serious adverse side effects. CONCLUSIONS: Intensive GMA in patients with active UC seems to be more efficacious than weekly treatment, and significantly reduced the patients' morbidity time without increasing the incidence of side effects.
    30 schema:genre article
    31 schema:inLanguage en
    32 schema:isAccessibleForFree false
    33 schema:isPartOf N3d27aadd326c4fe59ed7a7c142668407
    34 N5f2a7a24fe8e407ab9f2006b3ff906a3
    35 sg:journal.1019809
    36 schema:keywords ' morbidity time
    37 GMA
    38 GMA group
    39 GMA sessions
    40 GMA treatment
    41 GMA treatment group
    42 Open-Label Prospective Randomized Multicenter Study
    43 Prospective Randomized Multicenter Study
    44 active ulcerative colitis
    45 adsorptive apheresis
    46 adverse events
    47 adverse side effects
    48 aim
    49 analysis
    50 apheresis
    51 clinical efficacy
    52 clinical remission
    53 colitis
    54 date
    55 days
    56 effect
    57 efficacy
    58 efficacy analysis
    59 end
    60 events
    61 frequent treatment schedule
    62 granulocytes
    63 group
    64 incidence
    65 intensive GMA
    66 intensive GMA group
    67 intensive GMA treatment
    68 intensive granulocyte
    69 intensive treatment
    70 maximum number
    71 mean time
    72 mild
    73 monocyte adsorptive apheresis
    74 multicenter study
    75 number
    76 patients
    77 patients' morbidity time
    78 period
    79 protocol
    80 randomized multicenter study
    81 rapid remission
    82 rate
    83 remission
    84 remission rate
    85 routine weekly treatment
    86 routines
    87 safety
    88 schedule
    89 serious adverse side effects
    90 sessions
    91 side effects
    92 study
    93 study period
    94 time
    95 total
    96 treatment
    97 treatment groups
    98 treatment schedule
    99 ulcerative colitis
    100 weekly GMA
    101 weekly GMA treatment group
    102 weekly treatment
    103 weeks
    104 schema:name An Open-Label Prospective Randomized Multicenter Study Shows Very Rapid Remission of Ulcerative Colitis by Intensive Granulocyte and Monocyte Adsorptive Apheresis as Compared With Routine Weekly Treatment
    105 schema:pagination ajg2009453
    106 schema:productId N7b2f3367c8884bdb8befa4d19ed5fafe
    107 N839f3286bb80473b9f89d00b657a5d0c
    108 Nb58f45ce3a174820a920bd13535e6b31
    109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014082600
    110 https://doi.org/10.1038/ajg.2009.453
    111 schema:sdDatePublished 2021-11-01T18:12
    112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    113 schema:sdPublisher Nab142d5923d244049c0a03007d4aec8e
    114 schema:url https://doi.org/10.1038/ajg.2009.453
    115 sgo:license sg:explorer/license/
    116 sgo:sdDataset articles
    117 rdf:type schema:ScholarlyArticle
    118 N0b95b08bebcc431e93d2588b98b12feb rdf:first sg:person.01363432737.81
    119 rdf:rest Nbbddb0048eea4ffdac7460ca72a45ac8
    120 N0c4ba8eb46d0447a895eccbd25923e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Statistics, Nonparametric
    122 rdf:type schema:DefinedTerm
    123 N16df4f3bf0784f27961dddc54f911102 rdf:first sg:person.012162205442.47
    124 rdf:rest Nb426ec761bfe46718c580166c47b4c9b
    125 N1c897f67d5df4c8e840370ff41c2370c rdf:first sg:person.0651434566.83
    126 rdf:rest Nf8cf4155943d4e2a921c88df83a5d97a
    127 N1f34708504244b35ac9fa4368de676a9 rdf:first sg:person.0671355412.10
    128 rdf:rest N16df4f3bf0784f27961dddc54f911102
    129 N26f7e42da1f44eacb6bdb2843f0effe4 rdf:first sg:person.0733141344.48
    130 rdf:rest Ne03f7b3e11b840b8850e53834fb90f4d
    131 N335bd894f8454362baf86b99a8f4e829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Prospective Studies
    133 rdf:type schema:DefinedTerm
    134 N3d27aadd326c4fe59ed7a7c142668407 schema:issueNumber 12
    135 rdf:type schema:PublicationIssue
    136 N41e10aaaf6294bb6ae70d684fcf6950c rdf:first sg:person.01126763434.79
    137 rdf:rest N1c897f67d5df4c8e840370ff41c2370c
    138 N455a87fb6b6746628496e9130fff6c29 rdf:first sg:person.01146640377.43
    139 rdf:rest rdf:nil
    140 N4d779b62c9bf4e1099c1be2cadccf4c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Adsorption
    142 rdf:type schema:DefinedTerm
    143 N5ab70390ee83488ea7d14a91d98a1364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Monocytes
    145 rdf:type schema:DefinedTerm
    146 N5f2a7a24fe8e407ab9f2006b3ff906a3 schema:volumeNumber 104
    147 rdf:type schema:PublicationVolume
    148 N6087a34b2d7946abac158a761dbcbe90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Blood Component Removal
    150 rdf:type schema:DefinedTerm
    151 N66e2584f332d4cb9928d4a666efae5ab rdf:first sg:person.01362225512.44
    152 rdf:rest Nd750885407b14555a701fb502e940215
    153 N6f5efcef64f44bfea52c8e134f5fb6dd rdf:first sg:person.01075512433.93
    154 rdf:rest N66e2584f332d4cb9928d4a666efae5ab
    155 N7b2f3367c8884bdb8befa4d19ed5fafe schema:name pubmed_id
    156 schema:value 19724269
    157 rdf:type schema:PropertyValue
    158 N7ee60b19952e47829c60d532b0be9174 rdf:first sg:person.01153677003.50
    159 rdf:rest Ncee950407ab54a89b8ff7ae0cf42b0cb
    160 N839f3286bb80473b9f89d00b657a5d0c schema:name dimensions_id
    161 schema:value pub.1014082600
    162 rdf:type schema:PropertyValue
    163 N9ac91959172047a6834779b73c81d116 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Remission Induction
    165 rdf:type schema:DefinedTerm
    166 Na3241d09450f43b781b97c6097571f19 rdf:first sg:person.01215313304.62
    167 rdf:rest N26f7e42da1f44eacb6bdb2843f0effe4
    168 Na83853b919d442249a81f2b7228df8ba rdf:first sg:person.0610313122.34
    169 rdf:rest Ne83d77aaa84147209392ffec61fad43e
    170 Nab142d5923d244049c0a03007d4aec8e schema:name Springer Nature - SN SciGraph project
    171 rdf:type schema:Organization
    172 Nac5b7b2569b945538ea70d9ee39aef83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Adolescent
    174 rdf:type schema:DefinedTerm
    175 Nb426ec761bfe46718c580166c47b4c9b rdf:first sg:person.01160277320.14
    176 rdf:rest Ne0b9ee7a75d24315b34eee8dd60ea3c2
    177 Nb58f45ce3a174820a920bd13535e6b31 schema:name doi
    178 schema:value 10.1038/ajg.2009.453
    179 rdf:type schema:PropertyValue
    180 Nb9a6082564fb49fd9c0efe60f98e4544 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Colitis, Ulcerative
    182 rdf:type schema:DefinedTerm
    183 Nbbddb0048eea4ffdac7460ca72a45ac8 rdf:first sg:person.01070757373.14
    184 rdf:rest Na83853b919d442249a81f2b7228df8ba
    185 Nbc5c716c097243d58fc31f974cec6c81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Female
    187 rdf:type schema:DefinedTerm
    188 Nc4441f269e0343e0b70c39d5fb3f473a rdf:first sg:person.01332254073.98
    189 rdf:rest N455a87fb6b6746628496e9130fff6c29
    190 Nc6fc29265073499e96ef438a092515c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Aged
    192 rdf:type schema:DefinedTerm
    193 Ncee950407ab54a89b8ff7ae0cf42b0cb rdf:first sg:person.01233507634.87
    194 rdf:rest N0b95b08bebcc431e93d2588b98b12feb
    195 Nd24448cf8e934282ad9aac518b476bf3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Male
    197 rdf:type schema:DefinedTerm
    198 Nd510b47e89084569af5a732cf3b8e9cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Adult
    200 rdf:type schema:DefinedTerm
    201 Nd750885407b14555a701fb502e940215 rdf:first sg:person.01335473422.61
    202 rdf:rest N41e10aaaf6294bb6ae70d684fcf6950c
    203 Ne03f7b3e11b840b8850e53834fb90f4d rdf:first sg:person.0764046045.72
    204 rdf:rest Ne707e0e873254910b7247eb2147d38b4
    205 Ne0b9ee7a75d24315b34eee8dd60ea3c2 rdf:first sg:person.0627440023.46
    206 rdf:rest Na3241d09450f43b781b97c6097571f19
    207 Ne25b610d79f34c4ba521914be749bc99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Treatment Outcome
    209 rdf:type schema:DefinedTerm
    210 Ne58d2eadd9fb409f863e9b2df49fd8a6 rdf:first sg:person.0723101126.27
    211 rdf:rest N1f34708504244b35ac9fa4368de676a9
    212 Ne707e0e873254910b7247eb2147d38b4 rdf:first sg:person.01107367561.99
    213 rdf:rest N6f5efcef64f44bfea52c8e134f5fb6dd
    214 Ne82b09a8bdee4e338b9083c93d5d206f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Humans
    216 rdf:type schema:DefinedTerm
    217 Ne83d77aaa84147209392ffec61fad43e rdf:first sg:person.014575262532.25
    218 rdf:rest Neb4469f42ee74f13afbe3e5132b40ff9
    219 Neb4469f42ee74f13afbe3e5132b40ff9 rdf:first sg:person.011447440744.16
    220 rdf:rest Ne58d2eadd9fb409f863e9b2df49fd8a6
    221 Neeff8a9cefe4409eabc9134164c6a3f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Middle Aged
    223 rdf:type schema:DefinedTerm
    224 Nf8cf4155943d4e2a921c88df83a5d97a rdf:first sg:person.0634332227.48
    225 rdf:rest Nc4441f269e0343e0b70c39d5fb3f473a
    226 Nfc9a9d9752b5498a888b415870087a55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Granulocytes
    228 rdf:type schema:DefinedTerm
    229 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    230 schema:name Medical and Health Sciences
    231 rdf:type schema:DefinedTerm
    232 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Clinical Sciences
    234 rdf:type schema:DefinedTerm
    235 sg:journal.1019809 schema:issn 0002-9270
    236 1572-0241
    237 schema:name The American Journal of Gastroenterology
    238 schema:publisher Wolters Kluwer
    239 rdf:type schema:Periodical
    240 sg:person.01070757373.14 schema:affiliation grid-institutes:None
    241 schema:familyName Nishishita
    242 schema:givenName Masakazu
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070757373.14
    244 rdf:type schema:Person
    245 sg:person.01075512433.93 schema:affiliation grid-institutes:grid.410827.8
    246 schema:familyName Andoh
    247 schema:givenName Akira
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075512433.93
    249 rdf:type schema:Person
    250 sg:person.01107367561.99 schema:affiliation grid-institutes:grid.31432.37
    251 schema:familyName Aoyama
    252 schema:givenName Nobuo
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107367561.99
    254 rdf:type schema:Person
    255 sg:person.01126763434.79 schema:affiliation grid-institutes:None
    256 schema:familyName Suzuki
    257 schema:givenName Ryoichi
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126763434.79
    259 rdf:type schema:Person
    260 sg:person.011447440744.16 schema:affiliation grid-institutes:grid.265050.4
    261 schema:familyName Suzuki
    262 schema:givenName Yasuo
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011447440744.16
    264 rdf:type schema:Person
    265 sg:person.01146640377.43 schema:affiliation grid-institutes:grid.26091.3c
    266 schema:familyName Hibi
    267 schema:givenName Toshifumi
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146640377.43
    269 rdf:type schema:Person
    270 sg:person.01153677003.50 schema:affiliation grid-institutes:grid.26091.3c
    271 schema:familyName Sakuraba
    272 schema:givenName Atsushi
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153677003.50
    274 rdf:type schema:Person
    275 sg:person.01160277320.14 schema:affiliation grid-institutes:None
    276 schema:familyName Hanai
    277 schema:givenName Hiroyuki
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160277320.14
    279 rdf:type schema:Person
    280 sg:person.01215313304.62 schema:affiliation grid-institutes:grid.136304.3
    281 schema:familyName Yoshimura
    282 schema:givenName Naoki
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215313304.62
    284 rdf:type schema:Person
    285 sg:person.012162205442.47 schema:affiliation grid-institutes:grid.177174.3
    286 schema:familyName Matsumoto
    287 schema:givenName Takayuki
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47
    289 rdf:type schema:Person
    290 sg:person.01233507634.87 schema:affiliation grid-institutes:grid.415268.c
    291 schema:familyName Motoya
    292 schema:givenName Satoshi
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233507634.87
    294 rdf:type schema:Person
    295 sg:person.01332254073.98 schema:affiliation grid-institutes:grid.252427.4
    296 schema:familyName Ashida
    297 schema:givenName Toshifumi
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332254073.98
    299 rdf:type schema:Person
    300 sg:person.01335473422.61 schema:affiliation grid-institutes:grid.174567.6
    301 schema:familyName Mizuta
    302 schema:givenName Yohei
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335473422.61
    304 rdf:type schema:Person
    305 sg:person.01362225512.44 schema:affiliation grid-institutes:grid.258799.8
    306 schema:familyName Nakase
    307 schema:givenName Hiroshi
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362225512.44
    309 rdf:type schema:Person
    310 sg:person.01363432737.81 schema:affiliation grid-institutes:grid.261445.0
    311 schema:familyName Watanabe
    312 schema:givenName Kenji
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363432737.81
    314 rdf:type schema:Person
    315 sg:person.014575262532.25 schema:affiliation grid-institutes:grid.411556.2
    316 schema:familyName Matsui
    317 schema:givenName Toshiyuki
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014575262532.25
    319 rdf:type schema:Person
    320 sg:person.0610313122.34 schema:affiliation grid-institutes:grid.255137.7
    321 schema:familyName Kanke
    322 schema:givenName Kazunari
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610313122.34
    324 rdf:type schema:Person
    325 sg:person.0627440023.46 schema:affiliation grid-institutes:grid.272264.7
    326 schema:familyName Fukunaga
    327 schema:givenName Ken
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627440023.46
    329 rdf:type schema:Person
    330 sg:person.0634332227.48 schema:affiliation grid-institutes:grid.251924.9
    331 schema:familyName Iizuka
    332 schema:givenName Masahiro
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634332227.48
    334 rdf:type schema:Person
    335 sg:person.0651434566.83 schema:affiliation grid-institutes:grid.263518.b
    336 schema:familyName Akamatsu
    337 schema:givenName Taiji
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651434566.83
    339 rdf:type schema:Person
    340 sg:person.0671355412.10 schema:affiliation grid-institutes:grid.413045.7
    341 schema:familyName Kunisaki
    342 schema:givenName Reiko
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671355412.10
    344 rdf:type schema:Person
    345 sg:person.0723101126.27 schema:affiliation grid-institutes:grid.260433.0
    346 schema:familyName Oshima
    347 schema:givenName Tadayuki
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723101126.27
    349 rdf:type schema:Person
    350 sg:person.0733141344.48 schema:affiliation grid-institutes:grid.411790.a
    351 schema:familyName Chiba
    352 schema:givenName Toshimi
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733141344.48
    354 rdf:type schema:Person
    355 sg:person.0764046045.72 schema:affiliation grid-institutes:grid.415395.f
    356 schema:familyName Funakoshi
    357 schema:givenName Shinsuke
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764046045.72
    359 rdf:type schema:Person
    360 sg:pub.10.1007/bf00290518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014356510
    361 https://doi.org/10.1007/bf00290518
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1007/bf01296907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044553757
    364 https://doi.org/10.1007/bf01296907
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1007/s00535-004-1465-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1009327356
    367 https://doi.org/10.1007/s00535-004-1465-z
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1007/s00535-007-2129-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007758511
    370 https://doi.org/10.1007/s00535-007-2129-6
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nature06005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013517631
    373 https://doi.org/10.1038/nature06005
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/ncpgasthep0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045479349
    376 https://doi.org/10.1038/ncpgasthep0168
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.2165/00002018-199106030-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022649861
    379 https://doi.org/10.2165/00002018-199106030-00005
    380 rdf:type schema:CreativeWork
    381 grid-institutes:None schema:alternateName Kakegawa North Hospital, Kakegawa, Japan
    382 Kannai Suzuki Clinic, Yokohama, Japan
    383 Nishishita Intestinal Hospital, Osaka, Japan
    384 schema:name Kakegawa North Hospital, Kakegawa, Japan
    385 Kannai Suzuki Clinic, Yokohama, Japan
    386 Nishishita Intestinal Hospital, Osaka, Japan
    387 rdf:type schema:Organization
    388 grid-institutes:grid.136304.3 schema:alternateName Department of Internal Medicine, Chiba University, Chiba, Japan
    389 schema:name Department of Internal Medicine, Chiba University, Chiba, Japan
    390 rdf:type schema:Organization
    391 grid-institutes:grid.174567.6 schema:alternateName Department of Internal Medicine, Nagasaki University, Nagasaki, Japan
    392 schema:name Department of Internal Medicine, Nagasaki University, Nagasaki, Japan
    393 rdf:type schema:Organization
    394 grid-institutes:grid.177174.3 schema:alternateName Department of Internal Medicine, Kyusyu University, Fukuoka, Japan
    395 schema:name Department of Internal Medicine, Kyusyu University, Fukuoka, Japan
    396 rdf:type schema:Organization
    397 grid-institutes:grid.251924.9 schema:alternateName The First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    398 schema:name The First Department of Internal Medicine, Akita University School of Medicine, Akita, Japan
    399 rdf:type schema:Organization
    400 grid-institutes:grid.252427.4 schema:alternateName The Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    401 schema:name The Third Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan
    402 rdf:type schema:Organization
    403 grid-institutes:grid.255137.7 schema:alternateName Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan
    404 schema:name Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan
    405 rdf:type schema:Organization
    406 grid-institutes:grid.258799.8 schema:alternateName Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    407 schema:name Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    408 rdf:type schema:Organization
    409 grid-institutes:grid.260433.0 schema:alternateName Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    410 schema:name Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    411 rdf:type schema:Organization
    412 grid-institutes:grid.26091.3c schema:alternateName Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    413 schema:name Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    414 rdf:type schema:Organization
    415 grid-institutes:grid.261445.0 schema:alternateName Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    416 schema:name Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    417 rdf:type schema:Organization
    418 grid-institutes:grid.263518.b schema:alternateName Division of Gastroenterology, The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    419 schema:name Division of Gastroenterology, The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    420 rdf:type schema:Organization
    421 grid-institutes:grid.265050.4 schema:alternateName Department of Internal Medicine, Sakura Hospital, Toho University, Sakura, Japan
    422 schema:name Department of Internal Medicine, Sakura Hospital, Toho University, Sakura, Japan
    423 rdf:type schema:Organization
    424 grid-institutes:grid.272264.7 schema:alternateName Department of Gastroenterology, Hyogo College of Medicine, Hyougo, Japan
    425 schema:name Department of Gastroenterology, Hyogo College of Medicine, Hyougo, Japan
    426 rdf:type schema:Organization
    427 grid-institutes:grid.31432.37 schema:alternateName Department of Endoscopy, Kobe University School of Medicine, Kobe, Japan
    428 schema:name Department of Endoscopy, Kobe University School of Medicine, Kobe, Japan
    429 rdf:type schema:Organization
    430 grid-institutes:grid.410827.8 schema:alternateName Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
    431 schema:name Division of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
    432 rdf:type schema:Organization
    433 grid-institutes:grid.411556.2 schema:alternateName Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
    434 schema:name Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
    435 rdf:type schema:Organization
    436 grid-institutes:grid.411790.a schema:alternateName The First Department of Internal Medicine, Iwate Medical University School of Medicine, Masoka, Japan
    437 schema:name The First Department of Internal Medicine, Iwate Medical University School of Medicine, Masoka, Japan
    438 rdf:type schema:Organization
    439 grid-institutes:grid.413045.7 schema:alternateName Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
    440 schema:name Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan
    441 rdf:type schema:Organization
    442 grid-institutes:grid.415268.c schema:alternateName Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan
    443 schema:name Department of Gastroenterology, Sapporo Kosei General Hospital, Sapporo, Japan
    444 rdf:type schema:Organization
    445 grid-institutes:grid.415395.f schema:alternateName Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
    446 schema:name Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan
    447 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...