Mortality Rate and Risk Factors in Patients With Hereditary Pancreatitis: Uni- and Multidimensional Analyses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-06-23

AUTHORS

Vinciane Rebours, Marie-Christine Boutron-Ruault, Valérie Jooste, Anne-Marie Bouvier, Pascal Hammel, Philippe Ruszniewski, Philippe Lévy

ABSTRACT

OBJECTIVES: Patients with hereditary pancreatitis (HP) bear a high risk of pancreatic adenocarcinoma, but their life expectancy remains unknown. The objective of the study was to assess whether the high risk of cancer decreases survival. METHODS: Inclusion criteria were the presence of a PRSS1 mutation with pancreatic symptoms or chronic pancreatitis in at least two first-degree relatives or three second-degree relatives without another cause. Survival rates were assessed according to risk factors. Excess mortality compared with the general French population was calculated (statistical Esteve model) for two periods (20-50 and 50-70 years), according to several risk factors. RESULTS: The cohort comprised 189 patients. PRSS1 mutations were found in 66%. A total of 19 patients died at the median age of 60. In all, 10 deaths were attributable to HP, including 8 to pancreatic adenocarcinoma. Median overall survival for the whole cohort was 74 years (95% confidence interval (CI): 71-79). The presence of R122H mutation, gender, tobacco consumption in patients older than 18 years, and diabetes mellitus were not associated with differences in survival. Only patients with pancreatic cancer had decreased survival (P=0.008). Excess mortality risk compared with the general population was 0.02% between 20 and 50 years, and 0.61% between 50 and 70 years (NS). Gender, R122H mutation, diabetes, and tobacco use were not associated with excess mortality in these two periods. CONCLUSIONS: Despite their high risk of cancer, HP patients do not have excess mortality risk compared with the general population, irrespective of gender, tobacco use, or diabetes mellitus. These data should be brought to the patient's attention. More... »

PAGES

ajg2009363

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ajg.2009.363

DOI

http://dx.doi.org/10.1038/ajg.2009.363

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021111618

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19550412


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