The DNA sequence of human chromosome 22 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1999-12

AUTHORS

I. Dunham, A. R. Hunt, J. E. Collins, R. Bruskiewich, D. M. Beare, M. Clamp, L. J. Smink, R. Ainscough, J. P. Almeida, A. Babbage, C. Bagguley, J. Bailey, K. Barlow, K. N. Bates, O. Beasley, C. P. Bird, S. Blakey, A. M. Bridgeman, D. Buck, J. Burgess, W. D. Burrill, J. Burton, C. Carder, N. P. Carter, Y. Chen, G. Clark, S. M. Clegg, V. Cobley, C. G. Cole, R. E. Collier, R. E. Connor, D. Conroy, N. Corby, G. J. Coville, A. V. Cox, J. Davis, E. Dawson, P. D. Dhami, C. Dockree, S. J. Dodsworth, R. M. Durbin, A. Ellington, K. L. Evans, J. M. Fey, K. Fleming, L. French, A. A. Garner, J. G. R. Gilbert, M. E. Goward, D. Grafham, M. N. Griffiths, C. Hall, R. Hall, G. Hall-Tamlyn, R. W. Heathcott, S. Ho, S. Holmes, S. E. Hunt, M. C. Jones, J. Kershaw, A. Kimberley, A. King, G. K. Laird, C. F. Langford, M. A. Leversha, C. Lloyd, D. M. Lloyd, I. D. Martyn, M. Mashreghi-Mohammadi, L. Matthews, O. T. McCann, J. McClay, S. McLaren, A. A. McMurray, S. A. Milne, B. J. Mortimore, C. N. Odell, R. Pavitt, A. V. Pearce, D. Pearson, B. J. Phillimore, S. H. Phillips, R. W. Plumb, H. Ramsay, Y. Ramsey, L. Rogers, M. T. Ross, C. E. Scott, H. K. Sehra, C. D. Skuce, S. Smalley, M. L. Smith, C. Soderlund, L. Spragon, C. A. Steward, J. E. Sulston, R. M. Swann, M. Vaudin, M. Wall, J. M. Wallis, M. N. Whiteley, D. Willey, L. Williams, S. Williams, H. Williamson, T. E. Wilmer, L. Wilming, C. L. Wright, T. Hubbard, D. R. Bentley, S. Beck, J. Rogers, N. Shimizu, S. Minoshima, K. Kawasaki, T. Sasaki, S. Asakawa, J. Kudoh, A. Shintani, K. Shibuya, Y. Yoshizaki, N. Aoki, S. Mitsuyama, B. A. Roe, F. Chen, L. Chu, J. Crabtree, S. Deschamps, A. Do, T. Do, A. Dorman, F. Fang, Y. Fu, P. Hu, A. Hua, S. Kenton, H. Lai, H. I. Lao, J. Lewis, S. Lewis, S.-P. Lin, P. Loh, E. Malaj, T. Nguyen, H. Pan, S. Phan, S. Qi, Y. Qian, L. Ray, Q. Ren, S. Shaull, D. Sloan, L. Song, Q. Wang, Y. Wang, Z. Wang, J. White, D. Willingham, H. Wu, Z. Yao, M. Zhan, G. Zhang, S. Chissoe, J. Murray, N. Miller, P. Minx, R. Fulton, D. Johnson, G. Bemis, D. Bentley, H. Bradshaw, S. Bourne, M. Cordes, Z. Du, L. Fulton, D. Goela, T. Graves, J. Hawkins, K. Hinds, K. Kemp, P. Latreille, D. Layman, P. Ozersky, T. Rohlfing, P. Scheet, C. Walker, A. Wamsley, P. Wohldmann, K. Pepin, J. Nelson, I. Korf, J. A. Bedell, L. Hillier, E. Mardis, R. Waterston, R. Wilson, B. S. Emanuel, T. Shaikh, H. Kurahashi, S. Saitta, M. L. Budarf, H. E. McDermid, A. Johnson, A. C. C. Wong, B. E. Morrow, L. Edelmann, U. J. Kim, H. Shizuya, M. I. Simon, J. P. Dumanski, M. Peyrard, D. Kedra, E. Seroussi, I. Fransson, I. Tapia, C. E. Bruder, K. P. O'Brien

ABSTRACT

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and, by inference, the proteins they encode, as well as all other biologically important sequences. Furthermore, the sequence is a rich and permanent source of information for the design of further biological studies of the organism and for the study of evolution through cross-species sequence comparison. The power of this approach has been amply demonstrated by the determination of the sequences of a number of microbial and model organisms. The next step is to obtain the complete sequence of the entire human genome. Here we report the sequence of the euchromatic part of human chromosome 22. The sequence obtained consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome. More... »

PAGES

489

Journal

TITLE

Nature

ISSUE

6761

VOLUME

402

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/990031

    DOI

    http://dx.doi.org/10.1038/990031

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048671863

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10591208


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