In vivo molecular target assessment of matrix metalloproteinase inhibition View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-06

AUTHORS

C Bremer, C H Tung, R Weissleder

ABSTRACT

A number of different matrix metalloproteinase (MMP) inhibitors have been developed as cytostatic and anti-angiogenic agents and are currently in clinical testing. One major hurdle in assessing the efficacy of such drugs has been the inability to sense or image anti-proteinase activity directly and non-invasively in vivo. We show here that novel, biocompatible near-infrared fluorogenic MMP substrates can be used as activatable reporter probes to sense MMP activity in intact tumors in nude mice. Moreover, we show for the first time that the effect of MMP inhibition can be directly imaged using this approach within hours after initiation of treatment using the potent MMP inhibitor, prinomastat (AG3340). The developed probes, together with novel near-infrared fluorescence imaging technology will enable the detailed analysis of a number of proteinases critical for advancing the therapeutic use of clinical proteinase inhibitors. More... »

PAGES

743-748

Journal

TITLE

Nature Medicine

ISSUE

6

VOLUME

7

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/89126

    DOI

    http://dx.doi.org/10.1038/89126

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038138866

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11385514


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    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/89126'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/89126'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/89126'

    RDF/XML is a standard XML format for linked data.

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