Antigen decoding by T lymphocytes: from synapses to fate determination View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-06

AUTHORS

Antonio Lanzavecchia, Federica Sallusto

ABSTRACT

Naïve T lymphocytes sense foreign antigens by establishing contacts with dendritic cells (DCs). At the immunological synapse between the T cell and a DC, T cell receptors (TCRs) are serially engaged and triggered by specific ligands. The amount and duration of TCR triggering and the efficiency of signal amplification determine T cell commitment to proliferation and differentiation. The nature and availability of DCs bearing antigen and costimulatory molecules shape the T cell response, giving rise to distinct functional outputs such as effector and memory T cell generation or T cell tolerance. More... »

PAGES

ni0601_487

References to SciGraph publications

  • 2001-05. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells in NATURE IMMUNOLOGY
  • 2000-01. Cbl-b regulates the CD28 dependence of T-cell activation in NATURE
  • 2000-09. A cellular calculus for signal integration by T cells in NATURE IMMUNOLOGY
  • 2001-03. Visualizing the generation of memory CD4 T cells in the whole body in NATURE
  • 2001-05. Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation in NATURE IMMUNOLOGY
  • 1998-09. Three-dimensional segregation of supramolecular activation clusters in T cells in NATURE
  • 2001-03. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex in NATURE IMMUNOLOGY
  • 1995-05. Serial triggering of many T-cell receptors by a few peptide–MHC complexes in NATURE
  • 2000-01. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b in NATURE
  • 1996-10. Functional diversity of helper T lymphocytes in NATURE
  • 1993-04. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells in NATURE
  • 1992-04. Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor in NATURE
  • 2001-03. Skewed maturation of memory HIV-specific CD8 T lymphocytes in NATURE
  • 2000-10. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells in NATURE IMMUNOLOGY
  • 2000-07. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling in NATURE IMMUNOLOGY
  • 1999-10. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/88678

    DOI

    http://dx.doi.org/10.1038/88678

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008667353

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11376334


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigen Presentation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dendritic Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Down-Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocyte Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Antigen, T-Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Synapses", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universita della Svizzera Italiana", 
              "id": "https://www.grid.ac/institutes/grid.29078.34", 
              "name": [
                "Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lanzavecchia", 
            "givenName": "Antonio", 
            "id": "sg:person.01215457533.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215457533.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universita della Svizzera Italiana", 
              "id": "https://www.grid.ac/institutes/grid.29078.34", 
              "name": [
                "Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sallusto", 
            "givenName": "Federica", 
            "id": "sg:person.01147344333.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147344333.19"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1084/jem.187.10.1699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001058830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.18.5334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001072694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001596774", 
              "https://doi.org/10.1038/25764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/25764", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001596774", 
              "https://doi.org/10.1038/25764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.10.1775", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002321584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002780739", 
              "https://doi.org/10.1038/85286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002780739", 
              "https://doi.org/10.1038/85286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/87720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002891105", 
              "https://doi.org/10.1038/87720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200102)31:2<345::aid-immu345>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003047642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200102)31:2<345::aid-immu345>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003047642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80308-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003065142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.163.2.247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003681044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.141.1.138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003866445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005563195", 
              "https://doi.org/10.1038/35003228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003228", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005563195", 
              "https://doi.org/10.1038/35003228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.1.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006404282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/76877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006481675", 
              "https://doi.org/10.1038/76877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/76877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006481675", 
              "https://doi.org/10.1038/76877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.4.641", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007037083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.165.4.1141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008038468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.1997.tb00955.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009575237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80483-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010199839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.271.19.11441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010450763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.181.2.577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010582782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1074-7613(95)90161-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010596773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(05)80055-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010779663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.147.2.447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012288087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012309021", 
              "https://doi.org/10.1038/35065111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012309021", 
              "https://doi.org/10.1038/35065111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014254484", 
              "https://doi.org/10.1038/35003235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35003235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014254484", 
              "https://doi.org/10.1038/35003235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00362-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014731266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80149-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015646836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80161-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016541159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016546162", 
              "https://doi.org/10.1038/44385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/44385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016546162", 
              "https://doi.org/10.1038/44385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1058867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016773503"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1471-4906(01)01869-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017667430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00620-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017708802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/87730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018365256", 
              "https://doi.org/10.1038/87730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81633-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018680819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830260907", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019248554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-4141(199907)29:07<2197::aid-immu2197>3.0.co;2-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020379384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-5699(97)80027-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020570271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.12.040194.003223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022338908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.10.1803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022609674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.186.2.239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023928155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.191.7.1137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024661932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00066-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024874138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5483.1349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025319961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.18.1.593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025725889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025879915", 
              "https://doi.org/10.1038/79758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025879915", 
              "https://doi.org/10.1038/79758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80901-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025914521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.19.1.375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026112084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.189.10.1521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026425891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80630-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026539318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00384-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026624085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.18.10138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027055333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-4141(199905)29:05<1617::aid-immu1617>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028851221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830270912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029659011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80059-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030055641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.12.2133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030264530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030309971", 
              "https://doi.org/10.1038/79782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030309971", 
              "https://doi.org/10.1038/79782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/383787a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030311743", 
              "https://doi.org/10.1038/383787a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5397.2266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031368071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.190.1.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031442920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80383-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032184410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119798", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033181677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00870-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033435939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.07.040189.001521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035267012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80279-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037365561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.285.5425.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037590033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.184.2.777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037794075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80461-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038130375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.24.13932", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039870206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00076-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042029395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80952-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043122398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00032-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044610335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356793a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044711209", 
              "https://doi.org/10.1038/356793a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830271146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045457461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830270726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046231386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046408779", 
              "https://doi.org/10.1038/35065118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35065118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046408779", 
              "https://doi.org/10.1038/35065118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80577-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046846332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/375148a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047610851", 
              "https://doi.org/10.1038/375148a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-5699(99)01484-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047978202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/362758a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049008808", 
              "https://doi.org/10.1038/362758a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.2.219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049891530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.8.987", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049977544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80533-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050482944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.16.1.523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051525155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-4141(199807)28:07<2131::aid-immu2131>3.0.co;2-q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052560148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.192.8.1105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052799337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.185.10.1859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052826728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(96)80617-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053032098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1323144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062475363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.272.5258.54", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.273.5271.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062553494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2783497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062559087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.283.5402.680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062564014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.284.5415.819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062565106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.286.5441.952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062567134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.290.5489.92", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062571632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6427923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062637569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7535476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062647459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074482277", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074487406", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.4.2068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074679003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.9.4910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074717276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.12.6762", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074739624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.165.12.6833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074739633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.166.7.4278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074784820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079557309", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079785511", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082570097", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083293420", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083390211", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2001-06", 
        "datePublishedReg": "2001-06-01", 
        "description": "Na\u00efve T lymphocytes sense foreign antigens by establishing contacts with dendritic cells (DCs). At the immunological synapse between the T cell and a DC, T cell receptors (TCRs) are serially engaged and triggered by specific ligands. The amount and duration of TCR triggering and the efficiency of signal amplification determine T cell commitment to proliferation and differentiation. The nature and availability of DCs bearing antigen and costimulatory molecules shape the T cell response, giving rise to distinct functional outputs such as effector and memory T cell generation or T cell tolerance.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/88678", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1022778", 
            "issn": [
              "1529-2908", 
              "1529-2916"
            ], 
            "name": "Nature Immunology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "Antigen decoding by T lymphocytes: from synapses to fate determination", 
        "pagination": "ni0601_487", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "294b13c0a794e010214b270ae091d7617fd124c8bbe0016b9691f56cfbeefab5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11376334"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "100941354"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/88678"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1008667353"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/88678", 
          "https://app.dimensions.ai/details/publication/pub.1008667353"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:24", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/ni0601_487"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/88678'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/88678'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/88678'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/88678'


     

    This table displays all metadata directly associated to this object as RDF triples.

    453 TRIPLES      21 PREDICATES      148 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/88678 schema:about N0ac8e7d4ceba4b8bbd1f9e500a75bda3
    2 N20c77fd601584ed9a489f4fb27bd5c7a
    3 N21d1ae1aea5348a3a1d25b409e1104a6
    4 N3b1a76f6057947c18b936ce167be4320
    5 N4d96ce219bc14852910933c5e0c62b5b
    6 N6d76df93a9134e10add9b4114de75536
    7 N7d6928985e014a0698f0fa22f9f5d095
    8 N8f92079db5054433bd14f176ad82e022
    9 N91452da64065489bb5519bfe2c7df513
    10 N9312cf8949704a6187c31e6bfb4f2ab4
    11 Nc31335d222654defa003cdaf2746329a
    12 anzsrc-for:11
    13 anzsrc-for:1107
    14 schema:author N81490d3f58734caf84ee276957a078e3
    15 schema:citation sg:pub.10.1038/25764
    16 sg:pub.10.1038/35003228
    17 sg:pub.10.1038/35003235
    18 sg:pub.10.1038/35065111
    19 sg:pub.10.1038/35065118
    20 sg:pub.10.1038/356793a0
    21 sg:pub.10.1038/362758a0
    22 sg:pub.10.1038/375148a0
    23 sg:pub.10.1038/383787a0
    24 sg:pub.10.1038/44385
    25 sg:pub.10.1038/76877
    26 sg:pub.10.1038/79758
    27 sg:pub.10.1038/79782
    28 sg:pub.10.1038/85286
    29 sg:pub.10.1038/87720
    30 sg:pub.10.1038/87730
    31 https://app.dimensions.ai/details/publication/pub.1074482277
    32 https://app.dimensions.ai/details/publication/pub.1074487406
    33 https://app.dimensions.ai/details/publication/pub.1079557309
    34 https://app.dimensions.ai/details/publication/pub.1079785511
    35 https://app.dimensions.ai/details/publication/pub.1082570097
    36 https://app.dimensions.ai/details/publication/pub.1083293420
    37 https://app.dimensions.ai/details/publication/pub.1083390211
    38 https://doi.org/10.1002/(sici)1521-4141(199807)28:07<2131::aid-immu2131>3.0.co;2-q
    39 https://doi.org/10.1002/(sici)1521-4141(199905)29:05<1617::aid-immu1617>3.0.co;2-3
    40 https://doi.org/10.1002/(sici)1521-4141(199907)29:07<2197::aid-immu2197>3.0.co;2-b
    41 https://doi.org/10.1002/1521-4141(200102)31:2<345::aid-immu345>3.0.co;2-l
    42 https://doi.org/10.1002/eji.1830260907
    43 https://doi.org/10.1002/eji.1830270726
    44 https://doi.org/10.1002/eji.1830270912
    45 https://doi.org/10.1002/eji.1830271146
    46 https://doi.org/10.1016/0167-5699(96)80617-7
    47 https://doi.org/10.1016/1074-7613(95)90161-2
    48 https://doi.org/10.1016/s0092-8674(00)80059-8
    49 https://doi.org/10.1016/s0092-8674(00)80901-0
    50 https://doi.org/10.1016/s0092-8674(00)80952-6
    51 https://doi.org/10.1016/s0092-8674(00)81633-5
    52 https://doi.org/10.1016/s0092-8674(05)80055-8
    53 https://doi.org/10.1016/s0167-5699(97)80027-8
    54 https://doi.org/10.1016/s0167-5699(99)01484-x
    55 https://doi.org/10.1016/s0960-9822(00)00362-6
    56 https://doi.org/10.1016/s0960-9822(00)00384-5
    57 https://doi.org/10.1016/s0960-9822(00)00620-5
    58 https://doi.org/10.1016/s0960-9822(00)00870-8
    59 https://doi.org/10.1016/s1074-7613(00)00032-7
    60 https://doi.org/10.1016/s1074-7613(00)00066-2
    61 https://doi.org/10.1016/s1074-7613(00)00076-5
    62 https://doi.org/10.1016/s1074-7613(00)80149-1
    63 https://doi.org/10.1016/s1074-7613(00)80161-2
    64 https://doi.org/10.1016/s1074-7613(00)80279-4
    65 https://doi.org/10.1016/s1074-7613(00)80308-8
    66 https://doi.org/10.1016/s1074-7613(00)80383-0
    67 https://doi.org/10.1016/s1074-7613(00)80461-6
    68 https://doi.org/10.1016/s1074-7613(00)80483-5
    69 https://doi.org/10.1016/s1074-7613(00)80533-6
    70 https://doi.org/10.1016/s1074-7613(00)80577-4
    71 https://doi.org/10.1016/s1074-7613(00)80630-5
    72 https://doi.org/10.1016/s1471-4906(01)01869-5
    73 https://doi.org/10.1073/pnas.96.24.13932
    74 https://doi.org/10.1073/pnas.97.18.10138
    75 https://doi.org/10.1074/jbc.271.19.11441
    76 https://doi.org/10.1083/jcb.147.2.447
    77 https://doi.org/10.1084/jem.141.1.138
    78 https://doi.org/10.1084/jem.163.2.247
    79 https://doi.org/10.1084/jem.165.4.1141
    80 https://doi.org/10.1084/jem.181.2.577
    81 https://doi.org/10.1084/jem.184.2.777
    82 https://doi.org/10.1084/jem.185.10.1803
    83 https://doi.org/10.1084/jem.185.10.1859
    84 https://doi.org/10.1084/jem.185.12.2133
    85 https://doi.org/10.1084/jem.185.2.219
    86 https://doi.org/10.1084/jem.185.4.641
    87 https://doi.org/10.1084/jem.186.10.1775
    88 https://doi.org/10.1084/jem.186.2.239
    89 https://doi.org/10.1084/jem.187.10.1699
    90 https://doi.org/10.1084/jem.189.10.1521
    91 https://doi.org/10.1084/jem.190.1.31
    92 https://doi.org/10.1084/jem.191.7.1137
    93 https://doi.org/10.1084/jem.192.8.1105
    94 https://doi.org/10.1084/jem.193.1.35
    95 https://doi.org/10.1084/jem.193.8.987
    96 https://doi.org/10.1093/emboj/17.18.5334
    97 https://doi.org/10.1111/j.1600-065x.1997.tb00955.x
    98 https://doi.org/10.1126/science.1058867
    99 https://doi.org/10.1126/science.1323144
    100 https://doi.org/10.1126/science.272.5258.54
    101 https://doi.org/10.1126/science.273.5271.104
    102 https://doi.org/10.1126/science.2783497
    103 https://doi.org/10.1126/science.282.5397.2266
    104 https://doi.org/10.1126/science.283.5402.680
    105 https://doi.org/10.1126/science.284.5415.819
    106 https://doi.org/10.1126/science.285.5425.221
    107 https://doi.org/10.1126/science.286.5441.952
    108 https://doi.org/10.1126/science.289.5483.1349
    109 https://doi.org/10.1126/science.290.5489.92
    110 https://doi.org/10.1126/science.6427923
    111 https://doi.org/10.1126/science.7535476
    112 https://doi.org/10.1146/annurev.immunol.16.1.523
    113 https://doi.org/10.1146/annurev.immunol.18.1.593
    114 https://doi.org/10.1146/annurev.immunol.19.1.375
    115 https://doi.org/10.1146/annurev.iy.07.040189.001521
    116 https://doi.org/10.1146/annurev.iy.12.040194.003223
    117 https://doi.org/10.1172/jci119798
    118 https://doi.org/10.4049/jimmunol.165.12.6762
    119 https://doi.org/10.4049/jimmunol.165.12.6833
    120 https://doi.org/10.4049/jimmunol.165.4.2068
    121 https://doi.org/10.4049/jimmunol.165.9.4910
    122 https://doi.org/10.4049/jimmunol.166.7.4278
    123 schema:datePublished 2001-06
    124 schema:datePublishedReg 2001-06-01
    125 schema:description Naïve T lymphocytes sense foreign antigens by establishing contacts with dendritic cells (DCs). At the immunological synapse between the T cell and a DC, T cell receptors (TCRs) are serially engaged and triggered by specific ligands. The amount and duration of TCR triggering and the efficiency of signal amplification determine T cell commitment to proliferation and differentiation. The nature and availability of DCs bearing antigen and costimulatory molecules shape the T cell response, giving rise to distinct functional outputs such as effector and memory T cell generation or T cell tolerance.
    126 schema:genre research_article
    127 schema:inLanguage en
    128 schema:isAccessibleForFree false
    129 schema:isPartOf N503d30fb7261485da9ec8509ffd46397
    130 N9bd11892d1ee4c01bc659c4f06a4fb28
    131 sg:journal.1022778
    132 schema:name Antigen decoding by T lymphocytes: from synapses to fate determination
    133 schema:pagination ni0601_487
    134 schema:productId N0c0ee67d6e1545878576e8d5def8586c
    135 N807cfac4237f465797787f5b3d5f10a9
    136 Ncd942aea06e94ddcba18b38453841b24
    137 Ncff5db3432c840c484f67d56e5d4d14b
    138 Nd9487e1af9a04c63bb41301feccacc39
    139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008667353
    140 https://doi.org/10.1038/88678
    141 schema:sdDatePublished 2019-04-11T12:24
    142 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    143 schema:sdPublisher Nab73efc0e5f64e5dac987cb8b87518b6
    144 schema:url http://www.nature.com/articles/ni0601_487
    145 sgo:license sg:explorer/license/
    146 sgo:sdDataset articles
    147 rdf:type schema:ScholarlyArticle
    148 N0ac8e7d4ceba4b8bbd1f9e500a75bda3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Receptors, Antigen, T-Cell
    150 rdf:type schema:DefinedTerm
    151 N0c0ee67d6e1545878576e8d5def8586c schema:name readcube_id
    152 schema:value 294b13c0a794e010214b270ae091d7617fd124c8bbe0016b9691f56cfbeefab5
    153 rdf:type schema:PropertyValue
    154 N20c77fd601584ed9a489f4fb27bd5c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Antigen Presentation
    156 rdf:type schema:DefinedTerm
    157 N21d1ae1aea5348a3a1d25b409e1104a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Animals
    159 rdf:type schema:DefinedTerm
    160 N3b1a76f6057947c18b936ce167be4320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Lymphocyte Activation
    162 rdf:type schema:DefinedTerm
    163 N4d96ce219bc14852910933c5e0c62b5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name T-Lymphocytes
    165 rdf:type schema:DefinedTerm
    166 N503d30fb7261485da9ec8509ffd46397 schema:volumeNumber 2
    167 rdf:type schema:PublicationVolume
    168 N6d76df93a9134e10add9b4114de75536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Synapses
    170 rdf:type schema:DefinedTerm
    171 N7d6928985e014a0698f0fa22f9f5d095 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Humans
    173 rdf:type schema:DefinedTerm
    174 N807cfac4237f465797787f5b3d5f10a9 schema:name dimensions_id
    175 schema:value pub.1008667353
    176 rdf:type schema:PropertyValue
    177 N81490d3f58734caf84ee276957a078e3 rdf:first sg:person.01215457533.97
    178 rdf:rest Nc4a79909637d463ea00f269e7b7a9cd9
    179 N8f92079db5054433bd14f176ad82e022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Signal Transduction
    181 rdf:type schema:DefinedTerm
    182 N91452da64065489bb5519bfe2c7df513 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Dendritic Cells
    184 rdf:type schema:DefinedTerm
    185 N9312cf8949704a6187c31e6bfb4f2ab4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Cell Differentiation
    187 rdf:type schema:DefinedTerm
    188 N9bd11892d1ee4c01bc659c4f06a4fb28 schema:issueNumber 6
    189 rdf:type schema:PublicationIssue
    190 Nab73efc0e5f64e5dac987cb8b87518b6 schema:name Springer Nature - SN SciGraph project
    191 rdf:type schema:Organization
    192 Nc31335d222654defa003cdaf2746329a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Down-Regulation
    194 rdf:type schema:DefinedTerm
    195 Nc4a79909637d463ea00f269e7b7a9cd9 rdf:first sg:person.01147344333.19
    196 rdf:rest rdf:nil
    197 Ncd942aea06e94ddcba18b38453841b24 schema:name pubmed_id
    198 schema:value 11376334
    199 rdf:type schema:PropertyValue
    200 Ncff5db3432c840c484f67d56e5d4d14b schema:name doi
    201 schema:value 10.1038/88678
    202 rdf:type schema:PropertyValue
    203 Nd9487e1af9a04c63bb41301feccacc39 schema:name nlm_unique_id
    204 schema:value 100941354
    205 rdf:type schema:PropertyValue
    206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Medical and Health Sciences
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Immunology
    211 rdf:type schema:DefinedTerm
    212 sg:journal.1022778 schema:issn 1529-2908
    213 1529-2916
    214 schema:name Nature Immunology
    215 rdf:type schema:Periodical
    216 sg:person.01147344333.19 schema:affiliation https://www.grid.ac/institutes/grid.29078.34
    217 schema:familyName Sallusto
    218 schema:givenName Federica
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147344333.19
    220 rdf:type schema:Person
    221 sg:person.01215457533.97 schema:affiliation https://www.grid.ac/institutes/grid.29078.34
    222 schema:familyName Lanzavecchia
    223 schema:givenName Antonio
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215457533.97
    225 rdf:type schema:Person
    226 sg:pub.10.1038/25764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001596774
    227 https://doi.org/10.1038/25764
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/35003228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005563195
    230 https://doi.org/10.1038/35003228
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/35003235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014254484
    233 https://doi.org/10.1038/35003235
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/35065111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012309021
    236 https://doi.org/10.1038/35065111
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/35065118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046408779
    239 https://doi.org/10.1038/35065118
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/356793a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044711209
    242 https://doi.org/10.1038/356793a0
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/362758a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049008808
    245 https://doi.org/10.1038/362758a0
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/375148a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047610851
    248 https://doi.org/10.1038/375148a0
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/383787a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030311743
    251 https://doi.org/10.1038/383787a0
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/44385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016546162
    254 https://doi.org/10.1038/44385
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/76877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006481675
    257 https://doi.org/10.1038/76877
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/79758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025879915
    260 https://doi.org/10.1038/79758
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/79782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030309971
    263 https://doi.org/10.1038/79782
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/85286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002780739
    266 https://doi.org/10.1038/85286
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/87720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002891105
    269 https://doi.org/10.1038/87720
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/87730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018365256
    272 https://doi.org/10.1038/87730
    273 rdf:type schema:CreativeWork
    274 https://app.dimensions.ai/details/publication/pub.1074482277 schema:CreativeWork
    275 https://app.dimensions.ai/details/publication/pub.1074487406 schema:CreativeWork
    276 https://app.dimensions.ai/details/publication/pub.1079557309 schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1079785511 schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1082570097 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1083293420 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1083390211 schema:CreativeWork
    281 https://doi.org/10.1002/(sici)1521-4141(199807)28:07<2131::aid-immu2131>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1052560148
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1002/(sici)1521-4141(199905)29:05<1617::aid-immu1617>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028851221
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1002/(sici)1521-4141(199907)29:07<2197::aid-immu2197>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1020379384
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1002/1521-4141(200102)31:2<345::aid-immu345>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1003047642
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/eji.1830260907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019248554
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1002/eji.1830270726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046231386
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1002/eji.1830270912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029659011
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1002/eji.1830271146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045457461
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/0167-5699(96)80617-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053032098
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/1074-7613(95)90161-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010596773
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0092-8674(00)80059-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030055641
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s0092-8674(00)80901-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025914521
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s0092-8674(00)80952-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043122398
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/s0092-8674(00)81633-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018680819
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/s0092-8674(05)80055-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010779663
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0167-5699(97)80027-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020570271
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0167-5699(99)01484-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047978202
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0960-9822(00)00362-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014731266
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s0960-9822(00)00384-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026624085
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s0960-9822(00)00620-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017708802
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s0960-9822(00)00870-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033435939
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/s1074-7613(00)00032-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044610335
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s1074-7613(00)00066-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024874138
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s1074-7613(00)00076-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042029395
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s1074-7613(00)80149-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015646836
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/s1074-7613(00)80161-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016541159
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/s1074-7613(00)80279-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037365561
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s1074-7613(00)80308-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003065142
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/s1074-7613(00)80383-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032184410
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1016/s1074-7613(00)80461-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038130375
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1016/s1074-7613(00)80483-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010199839
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1016/s1074-7613(00)80533-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050482944
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1016/s1074-7613(00)80577-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046846332
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1016/s1074-7613(00)80630-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026539318
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1016/s1471-4906(01)01869-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017667430
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1073/pnas.96.24.13932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039870206
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1073/pnas.97.18.10138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027055333
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1074/jbc.271.19.11441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010450763
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1083/jcb.147.2.447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012288087
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1084/jem.141.1.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003866445
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1084/jem.163.2.247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003681044
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1084/jem.165.4.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008038468
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1084/jem.181.2.577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010582782
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1084/jem.184.2.777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037794075
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1084/jem.185.10.1803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022609674
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1084/jem.185.10.1859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052826728
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1084/jem.185.12.2133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030264530
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1084/jem.185.2.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049891530
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1084/jem.185.4.641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007037083
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1084/jem.186.10.1775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002321584
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1084/jem.186.2.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023928155
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1084/jem.187.10.1699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001058830
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1084/jem.189.10.1521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026425891
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1084/jem.190.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031442920
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1084/jem.191.7.1137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024661932
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1084/jem.192.8.1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052799337
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1084/jem.193.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006404282
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1084/jem.193.8.987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049977544
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1093/emboj/17.18.5334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001072694
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1111/j.1600-065x.1997.tb00955.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009575237
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1126/science.1058867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016773503
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1126/science.1323144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062475363
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1126/science.272.5258.54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552670
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1126/science.273.5271.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062553494
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1126/science.2783497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559087
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1126/science.282.5397.2266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031368071
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1126/science.283.5402.680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062564014
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1126/science.284.5415.819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565106
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1126/science.285.5425.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037590033
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1126/science.286.5441.952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062567134
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1126/science.289.5483.1349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025319961
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1126/science.290.5489.92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571632
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1126/science.6427923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062637569
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1126/science.7535476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062647459
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1146/annurev.immunol.16.1.523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051525155
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1146/annurev.immunol.18.1.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025725889
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1146/annurev.immunol.19.1.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026112084
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1146/annurev.iy.07.040189.001521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035267012
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1146/annurev.iy.12.040194.003223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022338908
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1172/jci119798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033181677
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.4049/jimmunol.165.12.6762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074739624
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.4049/jimmunol.165.12.6833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074739633
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.4049/jimmunol.165.4.2068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074679003
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.4049/jimmunol.165.9.4910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074717276
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.4049/jimmunol.166.7.4278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074784820
    450 rdf:type schema:CreativeWork
    451 https://www.grid.ac/institutes/grid.29078.34 schema:alternateName Universita della Svizzera Italiana
    452 schema:name Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500 Bellinzona, Switzerland.
    453 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...