Completeness in structural genomics View Full Text


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Article Info

DATE

2001-06

AUTHORS

Dennis Vitkup, Eugene Melamud, John Moult, Chris Sander

ABSTRACT

Structural genomics has the goal of obtaining useful, three-dimensional models of all proteins by a combination of experimental structure determination and comparative model building. We evaluate different strategies for optimizing information return on effort. The strategy that maximizes structural coverage requires about seven times fewer structure determinations compared with the strategy in which targets are selected at random. With a choice of reasonable model quality and the goal of 90% coverage, we extrapolate the estimate of the total effort of structural genomics. It would take ∼16,000 carefully selected structure determinations to construct useful atomic models for the vast majority of all proteins. In practice, unless there is global coordination of target selection, the total effort will likely increase by a factor of three. The task can be accomplished within a decade provided that selection of targets is highly coordinated and significant funding is available. More... »

PAGES

559-566

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/88640

DOI

http://dx.doi.org/10.1038/88640

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046431857

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11373627


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