Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-05

AUTHORS

M J van Stipdonk, E E Lemmens, S P Schoenberger

ABSTRACT

In defense of the host, the immune system must often raise an effective cytotoxic T lymphocyte (CTL) response from a small number of clonal precursors. The degree to which activation stimuli regulate the expansion and differentiation of naïve CTLs, however, remains unknown. Using an engineered antigen-presenting cell (APC) system that allows control over antigenic stimulation, we studied the signaling duration requirements for priming and clonal expansion of naïve CTLs. We found that naïve CTLs become committed after as little as 2 h of exposure to APCs and that their subsequent division and differentiation can occur without the need for further antigenic stimulation of the daughter cells, whether priming is in vitro or in vivo. These data show that after a brief interaction with stimulatory APCs, naïve CTLs initiate a program for their autonomous clonal expansion and development into functional effectors. More... »

PAGES

423-429

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/87730

DOI

http://dx.doi.org/10.1038/87730

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018365256

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11323696


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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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This table displays all metadata directly associated to this object as RDF triples.

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