A major susceptibility locus for leprosy in India maps to chromosome 10p13 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-04

AUTHORS

M. Ruby Siddiqui, Sarah Meisner, Kerrie Tosh, Karuppiah Balakrishnan, Satish Ghei, Simon E. Fisher, Marina Golding, Nallakandy P. Shanker Narayan, Thiagarajan Sitaraman, Utpal Sengupta, Ramasamy Pitchappan, Adrian V.S. Hill

ABSTRACT

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur1. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS)=4.09, P<2×10−5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA–linked loci exist that may be mapped through obtainable numbers of affected sibling pairs. More... »

PAGES

439-441

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/86958

DOI

http://dx.doi.org/10.1038/86958

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046378157

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11279529


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