Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-04

AUTHORS

Hiroyuki Aizawa, Shuji Wakatsuki, Ai Ishii, Kenji Moriyama, Yukio Sasaki, Kazumasa Ohashi, Yoko Sekine-Aizawa, Atsuko Sehara-Fujisawa, Kensaku Mizuno, Yoshio Goshima, Ichiro Yahara

ABSTRACT

Semaphorin 3A is a chemorepulsive axonal guidance molecule that depolymerizes the actin cytoskeleton and collapses growth cones of dorsal root ganglia neurons. Here we investigate the role of LIM-kinase 1, which phosphorylates an actin-depolymerizing protein, cofilin, in semaphorin 3A-induced growth cone collapse. Semaphorin 3A induced phosphorylation and dephosphorylation of cofilin at growth cones sequentially. A synthetic cell-permeable peptide containing a cofilin phosphorylation site inhibited LIM-kinase in vitro and in vivo, and essentially suppressed semaphorin 3A-induced growth cone collapse. A dominant-negative LIM kinase, which could not be activated by PAK or ROCK, suppressed the collapsing activity of semaphorin 3A. Phosphorylation of cofilin by LIM-kinase may be a critical signaling event in growth cone collapse by semaphorin 3A. More... »

PAGES

nn0401_367

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/86011

DOI

http://dx.doi.org/10.1038/86011

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026810019

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11276226


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