MHC-I–restricted presentation of HIV-1 virion antigens without viral replication View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Florence Buseyne, Sylvie Le Gall, Claire Boccaccio, Jean-Pierre Abastado, Jeffrey D. Lifson, Larry O. Arthur, Yves Rivière, Jean-Michel Heard, Olivier Schwartz

ABSTRACT

Dendritic cells and macrophages can process extracellular antigens for presentation by MHC-I molecules. This exogenous pathway may have a crucial role in the activation of CD8+ cytotoxic T lymphocytes during human viral infections. We show here that HIV-1 epitopes derived from incoming virions are presented through the exogenous MHC-I pathway in primary human dendritic cells, and to a lower extent in macrophages, leading to cytotoxic T-lymphocyte activation in the absence of viral protein synthesis. Exogenous antigen presentation required adequate virus-receptor interactions and fusion of viral and cellular membranes. These results provide new insights into how anti-HIV cytotoxic T lymphocytes can be activated and have implications for anti-HIV vaccine design. More... »

PAGES

344

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/85493

DOI

http://dx.doi.org/10.1038/85493

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011599531

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11231634


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/85493'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/85493'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/85493'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/85493'


 

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