Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

J Wolfers, A Lozier, G Raposo, A Regnault, C Théry, C Masurier, C Flament, S Pouzieux, F Faure, T Tursz, E Angevin, S Amigorena, L Zitvogel

ABSTRACT

The initiation of T-cell-mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell-dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions. More... »

PAGES

297-303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/85438

DOI

http://dx.doi.org/10.1038/85438

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027353534

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11231627


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