Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Anita Wolfer, Talitha Bakker, Anne Wilson, Michael Nicolas, Vassilios Ioannidis, Dan R. Littman, Christopher B. Wilson, Werner Held, H. Robson MacDonald, Freddy Radtke

ABSTRACT

Notch proteins influence cell-fate decisions in many developing systems. Several gain-of-function studies have suggested a critical role for Notch1 signaling in CD4-CD8 lineage commitment, matura-tion and survival in the thymus. However, we show here that tissue-specific inactivation of the gene encoding Notch1 in immature (CD25+CD44−) T cell precursors does not affect subsequent thymocyte development. Neither steady-state numbers nor the rate of production of CD4+ and CD8+ mature thymocytes is perturbed in the absence of Notch1. In addition, Notch1-deficient thymocytes are normally sensitive to spontaneous or glucocorticoid-induced apoptosis. In contrast to earlier re-ports, these data formally exclude an essential role for Notch1 in CD4-CD8 lineage commitment, maturation or survival. More... »

PAGES

235-241

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/85294

DOI

http://dx.doi.org/10.1038/85294

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051415468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11224523


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