Activity-dependent modification of inhibitory synapses in models of rhythmic neural networks View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-03

AUTHORS

Cristina Soto-Treviño, Kurt A. Thoroughman, Eve Marder, L. F. Abbott

ABSTRACT

The faithful production of rhythms by many neural circuits depends critically on the strengths of inhibitory synaptic connections. We propose a model in which the strengths of inhibitory synapses in a central pattern-generating circuit are subject to activity-dependent plasticity. The strength of each synapse is modified as a function of the global activity of the postsynaptic neuron and by correlated activity of the pre- and postsynaptic neurons. This allows the self-assembly, from random initial synaptic strengths, of two cells into reciprocal oscillation and three cells into a rhythmic triphasic motor pattern. This self-assembly illustrates that complex oscillatory circuits that depend on multiple inhibitory synaptic connections can be tuned via simple activity-dependent rules. More... »

PAGES

297-303

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/85147

DOI

http://dx.doi.org/10.1038/85147

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041891110

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11224547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Action Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crustacea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ganglia, Invertebrate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Neurological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Net", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Inhibition", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuronal Plasticity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Periodicity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.253264.4", 
          "name": [
            "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soto-Trevi\u00f1o", 
        "givenName": "Cristina", 
        "id": "sg:person.01067355634.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067355634.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.253264.4", 
          "name": [
            "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thoroughman", 
        "givenName": "Kurt A.", 
        "id": "sg:person.01310653543.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310653543.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.253264.4", 
          "name": [
            "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marder", 
        "givenName": "Eve", 
        "id": "sg:person.0611277053.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611277053.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.253264.4", 
          "name": [
            "Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abbott", 
        "givenName": "L. F.", 
        "id": "sg:person.01015001074.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015001074.26"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00961436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035201726", 
          "https://doi.org/10.1007/bf00961436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/28172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034809909", 
          "https://doi.org/10.1038/28172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00962719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053611171", 
          "https://doi.org/10.1007/bf00962719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00337410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016021450", 
          "https://doi.org/10.1007/bf00337410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00961435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020075817", 
          "https://doi.org/10.1007/bf00961435"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-03", 
    "datePublishedReg": "2001-03-01", 
    "description": "The faithful production of rhythms by many neural circuits depends critically on the strengths of inhibitory synaptic connections. We propose a model in which the strengths of inhibitory synapses in a central pattern-generating circuit are subject to activity-dependent plasticity. The strength of each synapse is modified as a function of the global activity of the postsynaptic neuron and by correlated activity of the pre- and postsynaptic neurons. This allows the self-assembly, from random initial synaptic strengths, of two cells into reciprocal oscillation and three cells into a rhythmic triphasic motor pattern. This self-assembly illustrates that complex oscillatory circuits that depend on multiple inhibitory synaptic connections can be tuned via simple activity-dependent rules.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/85147", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2685626", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2636027", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2547535", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "inhibitory synaptic connections", 
      "inhibitory synapses", 
      "postsynaptic neurons", 
      "synaptic connections", 
      "rhythmic neural networks", 
      "central pattern-generating circuits", 
      "initial synaptic strength", 
      "activity-dependent plasticity", 
      "activity-dependent modifications", 
      "pattern-generating circuits", 
      "synaptic strength", 
      "neural circuits", 
      "motor patterns", 
      "correlated activity", 
      "reciprocal oscillations", 
      "neurons", 
      "synapses", 
      "cells", 
      "synapse", 
      "activity", 
      "rhythm", 
      "pre", 
      "global activity", 
      "plasticity", 
      "function", 
      "patterns", 
      "faithful production", 
      "production", 
      "model", 
      "modification", 
      "connection", 
      "oscillatory circuit", 
      "strength", 
      "circuit", 
      "oscillations", 
      "network", 
      "neural network", 
      "rules"
    ], 
    "name": "Activity-dependent modification of inhibitory synapses in models of rhythmic neural networks", 
    "pagination": "297-303", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041891110"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/85147"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11224547"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/85147", 
      "https://app.dimensions.ai/details/publication/pub.1041891110"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_319.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/85147"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/85147'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/85147'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/85147'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/85147'


 

This table displays all metadata directly associated to this object as RDF triples.

190 TRIPLES      21 PREDICATES      80 URIs      67 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/85147 schema:about N00bf98e5dd224c2a85abe2646178df7b
2 N15c6479bb2c34d4889c98661d8a90e44
3 N38de98276c324ff4a78f4b3fe372c4ef
4 N505d60d43aeb4a0ab23b39743056de2d
5 N5fc6f3b30ebe4b01add1fbdb7104ed17
6 N61b590ae2c96439ca6259c625878dec8
7 N6bdecef87f1745589a7eeeaf7fb7cebe
8 N7ccf439b43df4f7ca7e0f4262ddee782
9 Nae66c1bae1b542be9c91afca01100eed
10 Nb6b08b8c524d4b14b5eacb6af716f74b
11 Nde91d70fcd0f45a0b1cf176029d1a8d2
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author N5592251f36bb4e13b8eab86c29f276a0
15 schema:citation sg:pub.10.1007/bf00337410
16 sg:pub.10.1007/bf00961435
17 sg:pub.10.1007/bf00961436
18 sg:pub.10.1007/bf00962719
19 sg:pub.10.1038/28172
20 schema:datePublished 2001-03
21 schema:datePublishedReg 2001-03-01
22 schema:description The faithful production of rhythms by many neural circuits depends critically on the strengths of inhibitory synaptic connections. We propose a model in which the strengths of inhibitory synapses in a central pattern-generating circuit are subject to activity-dependent plasticity. The strength of each synapse is modified as a function of the global activity of the postsynaptic neuron and by correlated activity of the pre- and postsynaptic neurons. This allows the self-assembly, from random initial synaptic strengths, of two cells into reciprocal oscillation and three cells into a rhythmic triphasic motor pattern. This self-assembly illustrates that complex oscillatory circuits that depend on multiple inhibitory synaptic connections can be tuned via simple activity-dependent rules.
23 schema:genre article
24 schema:isAccessibleForFree false
25 schema:isPartOf Nfc44032a85b449b8bfe26496287e681f
26 Nfeff04d44c6d4f9a9570d93b4c0d55c5
27 sg:journal.1118362
28 schema:keywords activity
29 activity-dependent modifications
30 activity-dependent plasticity
31 cells
32 central pattern-generating circuits
33 circuit
34 connection
35 correlated activity
36 faithful production
37 function
38 global activity
39 inhibitory synapses
40 inhibitory synaptic connections
41 initial synaptic strength
42 model
43 modification
44 motor patterns
45 network
46 neural circuits
47 neural network
48 neurons
49 oscillations
50 oscillatory circuit
51 pattern-generating circuits
52 patterns
53 plasticity
54 postsynaptic neurons
55 pre
56 production
57 reciprocal oscillations
58 rhythm
59 rhythmic neural networks
60 rules
61 strength
62 synapse
63 synapses
64 synaptic connections
65 synaptic strength
66 schema:name Activity-dependent modification of inhibitory synapses in models of rhythmic neural networks
67 schema:pagination 297-303
68 schema:productId N17f0ce923bae44fb9d165538f6810021
69 N2eb1d6ff60424c2ba8dd25aa21d6a49d
70 N6c0bfae0224a4cfbaf9da169f3671f7a
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041891110
72 https://doi.org/10.1038/85147
73 schema:sdDatePublished 2022-10-01T06:31
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nb1327b10266946f481ae967df28489d1
76 schema:url https://doi.org/10.1038/85147
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N00bf98e5dd224c2a85abe2646178df7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Ganglia, Invertebrate
82 rdf:type schema:DefinedTerm
83 N15c6479bb2c34d4889c98661d8a90e44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Neuronal Plasticity
85 rdf:type schema:DefinedTerm
86 N17f0ce923bae44fb9d165538f6810021 schema:name dimensions_id
87 schema:value pub.1041891110
88 rdf:type schema:PropertyValue
89 N2eb1d6ff60424c2ba8dd25aa21d6a49d schema:name pubmed_id
90 schema:value 11224547
91 rdf:type schema:PropertyValue
92 N38de98276c324ff4a78f4b3fe372c4ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Neural Inhibition
94 rdf:type schema:DefinedTerm
95 N505d60d43aeb4a0ab23b39743056de2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Synapses
97 rdf:type schema:DefinedTerm
98 N526c4613297743479b9add72f13de81a rdf:first sg:person.0611277053.27
99 rdf:rest N62b9d585cfb641b68604d746c052f0af
100 N5592251f36bb4e13b8eab86c29f276a0 rdf:first sg:person.01067355634.72
101 rdf:rest N85e9c25acd52440da4cfab566a33b66b
102 N5fc6f3b30ebe4b01add1fbdb7104ed17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Crustacea
104 rdf:type schema:DefinedTerm
105 N61b590ae2c96439ca6259c625878dec8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Action Potentials
107 rdf:type schema:DefinedTerm
108 N62b9d585cfb641b68604d746c052f0af rdf:first sg:person.01015001074.26
109 rdf:rest rdf:nil
110 N6bdecef87f1745589a7eeeaf7fb7cebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Periodicity
112 rdf:type schema:DefinedTerm
113 N6c0bfae0224a4cfbaf9da169f3671f7a schema:name doi
114 schema:value 10.1038/85147
115 rdf:type schema:PropertyValue
116 N7ccf439b43df4f7ca7e0f4262ddee782 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Neurons
118 rdf:type schema:DefinedTerm
119 N85e9c25acd52440da4cfab566a33b66b rdf:first sg:person.01310653543.19
120 rdf:rest N526c4613297743479b9add72f13de81a
121 Nae66c1bae1b542be9c91afca01100eed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Nerve Net
123 rdf:type schema:DefinedTerm
124 Nb1327b10266946f481ae967df28489d1 schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 Nb6b08b8c524d4b14b5eacb6af716f74b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Animals
128 rdf:type schema:DefinedTerm
129 Nde91d70fcd0f45a0b1cf176029d1a8d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Models, Neurological
131 rdf:type schema:DefinedTerm
132 Nfc44032a85b449b8bfe26496287e681f schema:issueNumber 3
133 rdf:type schema:PublicationIssue
134 Nfeff04d44c6d4f9a9570d93b4c0d55c5 schema:volumeNumber 4
135 rdf:type schema:PublicationVolume
136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
137 schema:name Medical and Health Sciences
138 rdf:type schema:DefinedTerm
139 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
140 schema:name Neurosciences
141 rdf:type schema:DefinedTerm
142 sg:grant.2547535 http://pending.schema.org/fundedItem sg:pub.10.1038/85147
143 rdf:type schema:MonetaryGrant
144 sg:grant.2636027 http://pending.schema.org/fundedItem sg:pub.10.1038/85147
145 rdf:type schema:MonetaryGrant
146 sg:grant.2685626 http://pending.schema.org/fundedItem sg:pub.10.1038/85147
147 rdf:type schema:MonetaryGrant
148 sg:journal.1118362 schema:issn 1097-6256
149 1546-1726
150 schema:name Nature Neuroscience
151 schema:publisher Springer Nature
152 rdf:type schema:Periodical
153 sg:person.01015001074.26 schema:affiliation grid-institutes:grid.253264.4
154 schema:familyName Abbott
155 schema:givenName L. F.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015001074.26
157 rdf:type schema:Person
158 sg:person.01067355634.72 schema:affiliation grid-institutes:grid.253264.4
159 schema:familyName Soto-Treviño
160 schema:givenName Cristina
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067355634.72
162 rdf:type schema:Person
163 sg:person.01310653543.19 schema:affiliation grid-institutes:grid.253264.4
164 schema:familyName Thoroughman
165 schema:givenName Kurt A.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310653543.19
167 rdf:type schema:Person
168 sg:person.0611277053.27 schema:affiliation grid-institutes:grid.253264.4
169 schema:familyName Marder
170 schema:givenName Eve
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611277053.27
172 rdf:type schema:Person
173 sg:pub.10.1007/bf00337410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016021450
174 https://doi.org/10.1007/bf00337410
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/bf00961435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020075817
177 https://doi.org/10.1007/bf00961435
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/bf00961436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035201726
180 https://doi.org/10.1007/bf00961436
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/bf00962719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053611171
183 https://doi.org/10.1007/bf00962719
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/28172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034809909
186 https://doi.org/10.1038/28172
187 rdf:type schema:CreativeWork
188 grid-institutes:grid.253264.4 schema:alternateName Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA
189 schema:name Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, 02454-9110, Waltham, Massachusetts, USA
190 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...