VEGF-D promotes the metastatic spread of tumor cells via the lymphatics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-02

AUTHORS

Steven A. Stacker, Carol Caesar, Megan E. Baldwin, Gillian E. Thornton, Richard A. Williams, Remko Prevo, David G. Jackson, Shin-ichi Nishikawa, Hajime Kubo, Marc G. Achen

ABSTRACT

Metastasis to local lymph nodes via the lymphatic vessels is a common step in the spread of solid tumors. To investigate the molecular mechanisms underlying the spread of cancer by the lymphatics, we examined the ability of vascular endothelial growth factor (VEGF)-D, a ligand for the lymphatic growth factor receptor VEGFR-3/Flt-4, to induce formation of lymphatics in a mouse tumor model. Staining with markers specific for lymphatic endothelium demonstrated that VEGF-D induced the formation of lymphatics within tumors. Moreover, expression of VEGF-D in tumor cells led to spread of the tumor to lymph nodes, whereas expression of VEGF, an angiogenic growth factor which activates VEGFR-2 but not VEGFR-3, did not. VEGF-D also promoted tumor angiogenesis and growth. Lymphatic spread induced by VEGF-D could be blocked with an antibody specific for VEGF-D. This study demonstrates that lymphatics can be established in solid tumors and implicates VEGF family members in determining the route of metastatic spread. More... »

PAGES

nm0201_186

Journal

TITLE

Nature Medicine

ISSUE

2

VOLUME

7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/84635

DOI

http://dx.doi.org/10.1038/84635

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014520430

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11175849


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/84635'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/84635'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/84635'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/84635'


 

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