Chemical-regulated, site-specific DNA excision in transgenic plants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-02

AUTHORS

J Zuo, Q W Niu, S G Møller, N H Chua

ABSTRACT

We have developed a chemical-inducible, site-specific DNA excision system in transgenic Arabidopsis plants mediated by the Cre/loxP DNA recombination system. Expression of the Cre recombinase was tightly controlled by an estrogen receptor-based fusion transactivator XVE. Upon induction by beta-estradiol, sequences encoding the selectable marker, Cre, and XVE sandwiched by two loxP sites were excised from the Arabidopsis genome, leading to activation of the downstream GFP (green fluorescent protein) reporter gene. Genetic and molecular analyses indicated that the system is tightly controlled, showing high-efficiency inducible DNA excision in all 19 transgenic events tested with either single or multiple T-DNA insertions. The system provides a highly reliable method to generate marker-free transgenic plants after transformation through either organogenesis or somatic embryogenesis. More... »

PAGES

157-161

Journal

TITLE

Nature Biotechnology

ISSUE

2

VOLUME

19

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/84428

DOI

http://dx.doi.org/10.1038/84428

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022691725

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11175731


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