Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-05-01

AUTHORS

Diana Finzi, Joel Blankson, Janet D. Siliciano, Joseph B. Margolick, Karen Chadwick, Theodore Pierson, Kendall Smith, Julianna Lisziewicz, Franco Lori, Charles Flexner, Thomas C. Quinn, Richard E. Chaisson, Eric Rosenberg, Bruce Walker, Stephen Gange, Joel Gallant, Robert F. Siliciano

ABSTRACT

Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable. The mean half-life of the latent reservoir was very long (43.9 months). If the latent reservoir consists of only 1 × 105 cells, eradication could take as long as 60 years. Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective anti-retroviral therapy. More... »

PAGES

512-517

Journal

TITLE

Nature Medicine

ISSUE

5

VOLUME

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/8394

DOI

http://dx.doi.org/10.1038/8394

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049869736

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10229227


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32 schema:description Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels, indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist in a latent form in resting CD4+ T cells. We measured the decay rate of this latent reservoir in 34 treated adults whose plasma virus levels were undetectable. The mean half-life of the latent reservoir was very long (43.9 months). If the latent reservoir consists of only 1 × 105 cells, eradication could take as long as 60 years. Thus, latent infection of resting CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective anti-retroviral therapy.
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