Counting alleles reveals a connection between chromosome 18q loss and vascular invasion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-01

AUTHORS

W Zhou, G Galizia, E Lieto, S N Goodman, K E Romans, K W Kinzler, B Vogelstein, M A Choti, E A Montgomery

ABSTRACT

The analysis of loss of heterozygosity (LOH) is perhaps the most widely used technique in cancer genetics. In primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its reproducibility and interpretation. In particular, tumors are mixtures of neoplastic and nonneoplastic cells, and the DNA from the nonneoplastic cells can mask LOH. We here describe a new experimental approach, involving two components, to overcome these problems. First, a form of digital PCR was employed to directly count, one by one, the number of each of the two alleles in tumor samples. Second, Bayesian-type likelihood methods were used to measure the strength of the evidence for the allele distribution being different from normal. This approach imparts a rigorous statistical basis to LOH analyses, and should be able to provide more reliable information than heretofore possible in LOH studies of diverse tumor types. More... »

PAGES

78

Journal

TITLE

Nature Biotechnology

ISSUE

1

VOLUME

19

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/83572

    DOI

    http://dx.doi.org/10.1038/83572

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001065071

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11135558


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