A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-01

AUTHORS

Léonie M. Raamsdonk, Bas Teusink, David Broadhurst, Nianshu Zhang, Andrew Hayes, Michael C. Walsh, Jan A. Berden, Kevin M. Brindle, Douglas B. Kell, Jem J. Rowland, Hans V. Westerhoff, Karel van Dam, Stephen G. Oliver

ABSTRACT

A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae, and of those sequenced in other organisms, encode proteins of unknown function. Many of these genes are "silent, " that is, they show no overt phenotype, in terms of growth rate or other fluxes, when they are deleted from the genome. We demonstrate how the intracellular concentrations of metabolites can reveal phenotypes for proteins active in metabolic regulation. Quantification of the change of several metabolite concentrations relative to the concentration change of one selected metabolite can reveal the site of action, in the metabolic network, of a silent gene. In the same way, comprehensive analyses of metabolite concentrations in mutants, providing "metabolic snapshots," can reveal functions when snapshots from strains deleted for unstudied genes are compared to those deleted for known genes. This approach to functional analysis, using comparative metabolomics, we call FANCY-an abbreviation for functional analysis by co-responses in yeast. More... »

PAGES

nbt0101_45

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/83496

    DOI

    http://dx.doi.org/10.1038/83496

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1011462196

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11135551


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