Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-01

AUTHORS

L P Kane, P G Andres, K C Howland, A K Abbas, A Weiss

ABSTRACT

A region of the interleukin-2 (IL-2) promoter known as the RE/AP element is activated in concert by signals that originate from the T cell antigen receptor and the CD28 coreceptor. We show here that the serine-threonine kinase Akt can provide a costimulatory signal for RE/AP activation that is indistinguishable from the signal provided by CD28. This includes the ability of Akt, like antibodies to CD28, to synergize with protein kinase C theta (PKC-theta) in the induction of RE/AP. Retrovirus-mediated expression of activated Akt in primary T cells from CD28-deficient mice is capable of selectively restoring production of IL-2 and interferon gamma, but not IL-4 or IL-5. Our results provide evidence that CD28 costimulation of different cytokines is mediated by discrete signaling pathways, one of which includes Akt. More... »

PAGES

37-44

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/83144

DOI

http://dx.doi.org/10.1038/83144

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031575838

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11135576


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