Artificial antigen-presenting cells as a tool to exploit the immune `synapse' View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-12

AUTHORS

B Prakken, M Wauben, D Genini, R Samodal, J Barnett, A Mendivil, L Leoni, S Albani

ABSTRACT

Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction. More... »

PAGES

1406-1410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/82231

DOI

http://dx.doi.org/10.1038/82231

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026037588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11100129


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