Purified hematopoietic stem cells can differentiate into hepatocytes in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

Eric Lagasse, Heather Connors, Muhsen Al-Dhalimy, Michael Reitsma, Monika Dohse, Linda Osborne, Xin Wang, Milton Finegold, Irving L. Weissman, Markus Grompe

ABSTRACT

The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells. More... »

PAGES

1229-1234

Journal

TITLE

Nature Medicine

ISSUE

11

VOLUME

6

Related Patents

  • Methods For Differentiating Cells Into Hepatic Stellate Cells And Hepatic Sinusoidal Endothelial Cells, Cells Produced By The Methods, And Methods For Using The Cells
  • Methods For Collecting And Using Placenta Cord Blood Stem Cells
  • Cellular Labeling For Nuclear Magnetic Resonance Techniques
  • Compositions And Methods For Producing Cellular Labels For Nuclear Magnetic Resonance Techniques
  • Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells
  • Cellular Labeling For Nuclear Magnetic Resonance Techniques
  • Methods And Uses For Ex Vivo Tissue Culture Systems
  • Regulating Stem Cells
  • Modulation Of Stem Cells Using Zinc Finger Proteins
  • Mapc Treatment Of Brain Injuries And Diseases
  • Method For Enhancing Stem Cell Trafficking
  • Use Of Multipotent Adult Stem Cells In Treatment Of Myocardial Infarction And Congestive Heart Failure
  • Organs For Transplantation
  • Enhancement Of Natural Killer (Nk) Cell Proliferation And Activity
  • Of Non-Embryonic Origin That Can Be Maintained In Culture In The Undifferentiated State Or Differentiated To Form Cells Of Multiple Cell Types; Used For Xenogeneic Transplantation And/Or Tissue Repair
  • Method For Enhancing Stem Cell Trafficking
  • Immunomodulatory Properties Of Multipotent Adult Progenitor Cells And Uses Thereof
  • Multipotent Adult Stem Cells And Methods For Isolation
  • Cannula For Tissue Disruption
  • Isolated Adult Pluripotent Stem Cells And Methods For Isolating And Cultivating Thereof
  • Mapc Treatment Of Brain Injuries And Diseases
  • Organs For Transplantation
  • Neuroprotection By Hepatic Cells And Hepatocyte Secretory Factors
  • Multipotent Adult Stem Cells And Methods For Isolation
  • Materials And Methods Relating To Cell Based Therapies
  • Methods Of Culturing And Expanding Mesenchymal Stem Cells
  • Use Of Multipotent Adult Stem Cells In Treatment Of Myocardial Infarction And Congestive Heart Failure
  • Stem Cell Aggregates And Methods For Making And Using
  • Isolated Adult Pluripotent Stem Cells And Methods For Isolating And Cultivating Thereof
  • Device And Method For Rapid Aspiration And Collection Of Body Tissue From Within An Enclosed Body Space
  • Methods For Differentiating Cells Into Hepatic Stellate Cells And Hepatic Sinusoidal Endothelial Cells, Cells Produced By The Method, And Methods For Using The Cells
  • Multipotent Adult Stem Cells And Methods For Isolation
  • Composition Comprising A Progenitor/Precursor Cell Population
  • Isolation Of Cd14 Negative, Cd45 Positive And Cd117 Positive Embryonic-Like Stem Cells Free Of Monocytes From Human Umbilical Cord Blood Mononuclear Cells
  • Composition Of Matter For Delivering And/Or Affixing A Stem Cell To A Target Tissue Comprising A First Moiety That Specifically Binds To The Stem Cell Surface Operably Affixed To A Second Moiety That Specifically Binds To The Surface Of A Cell In The Tissue
  • Multipotent Adult Stem Cells And Methods For Isolation
  • Mesoderm And Definitive Endoderm Cell Populations
  • Cardioprotective Role Of Hepatic Cells And Hepatocyte Secretory Factors In Myocardial Ischemia
  • Methods Of Ex Vivo Hematopoietic Stem Cell Expansion By Co-Culture With Mesenchymal Cells
  • Methods Of Controlling Proliferation And Differentiation Of Stem And Progenitor Cells
  • Differentiation Of Non-Embryonic Stem Cells To Cells Having A Pancreatic Phenotype
  • Embryonic-Like Stem Cells Derived From Adult Human Peripheral Blood And Methods Of Use
  • Consumption Of Blue-Green Algae, Such As, But Not Limited To, Aphanizomenon Flos Aquae (Afa), Induces Mobilization Of Endogenous Stem Cells Into Circulatory System Where They May Come Into Contact With Multiple Organs And Tissues
  • Regulating Stem Cells
  • Modulation Of Splenocytes In Cell Therapy
  • In Vitro Techniques For Use With Stem Cells
  • Non-Static Suspension Culture Of Cell Aggregates
  • Methods For Collecting And Using Placenta Cord Blood Stem Cell
  • Liver Engrafting Cells, Assays, And Uses Thereof
  • Culturing Of Mesenchymal Stem Cells With Fgf4 And Nicotinamide
  • Multipotent Adult Stem Cells, Sources Thereof, Methods Of Obtaining And Maintaining Same, Methods Of Differentiation Thereof, Methods Of Use Thereof And Cells Derived Thereof
  • Drug Mobilizing Pluripotent Stem Cells From Tissue Into Peripheral Blood
  • Methods For Collecting And Using Placenta Cord Blood Stem Cells
  • Multipotent Adult Stem Cells And Methods For Isolation
  • Expanded Human Multipotent, Non-Embryonic, Non-Germ Cells That Can Differentiate Into At Least One Cell Type Of Each Of The Endodermal, Ectodermal, And Mesodermal Embryonic Lineages And Express Telomerase; Cardiovascular, Nervous System Diseases
  • Methods Of Expanding Stem And Progenitor Cells And Expanded Cell Populations Obtained Thereby
  • Lymph Nodes As A Site For Regeneration
  • Modulation Of Splenocytes In Cell Therapy
  • Optimized Methods For Differentiation Of Cells Into Cells With Hepatocyte And Hepatocyte Progenitor Phenotypes, Cells Produced By The Methods, And Methods For Using The Cells
  • Cellular Labeling And Quantification For Nuclear Magnetic Resonance Techniques
  • Immunomodulatory Properties Of Multipotent Adult Progenitor Cells And Uses Thereof
  • Homologous Recombination In Multipotent Adult Progenitor Cells
  • Homologous Recombination In Multipotent Adult Progenitor Cells
  • Modulation Of Stem Cells Using Zinc Finger Proteins
  • Mapc Generation Of Lung Tissue
  • Regulating Stem Cells
  • Regulating Stem Cells
  • Methods Of Improving Stem Cell Homing And Engraftment
  • Non-Static Suspension Culture Of Cell Aggregates
  • Pluripotent Culture In Which Cells Are Capable Of Differentiating Into Mesodermal, Ectodermal And Endodermal Tissue Types; Gene Therapy And Tissue Engineering
  • Method For Producing A Dc Vaccine Against Cancer
  • Device And Method For Rapid Aspiration And Collection Of Body Tissue From Within An Enclosed Body Space
  • Modulation Of Stem Cells Using Zinc Finger Proteins
  • Human Liver Engrafting Cells Isolated From Adult Liver Tissue
  • Neuroprotection By Hepatic Cells And Hepatocyte Secretory Factors
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/81326

    DOI

    http://dx.doi.org/10.1038/81326

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039353607

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11062533


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Separation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoietic Stem Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydrolases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Regeneration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred Strains", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tyrosinemias", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Whole-Body Irradiation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.422597.f", 
              "name": [
                "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lagasse", 
            "givenName": "Eric", 
            "id": "sg:person.01315133635.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315133635.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.422597.f", 
              "name": [
                "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Connors", 
            "givenName": "Heather", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA", 
              "id": "http://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Al-Dhalimy", 
            "givenName": "Muhsen", 
            "id": "sg:person.015321277547.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015321277547.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.422597.f", 
              "name": [
                "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reitsma", 
            "givenName": "Michael", 
            "id": "sg:person.01203031110.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203031110.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.422597.f", 
              "name": [
                "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dohse", 
            "givenName": "Monika", 
            "id": "sg:person.0715517620.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715517620.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.422597.f", 
              "name": [
                "StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Osborne", 
            "givenName": "Linda", 
            "id": "sg:person.01250211075.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250211075.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA", 
              "id": "http://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Xin", 
            "id": "sg:person.01130627336.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130627336.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Texas Children's Hospital Baylor College of Medicine, 77030, Houston, Texas, USA", 
              "id": "http://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pathology, Texas Children's Hospital Baylor College of Medicine, 77030, Houston, Texas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Finegold", 
            "givenName": "Milton", 
            "id": "sg:person.014103516477.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014103516477.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology and Developmental Biology Stanford University School of Medicine, 94305, Stanford, California, USA", 
              "id": "http://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Department of Pathology and Developmental Biology Stanford University School of Medicine, 94305, Stanford, California, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weissman", 
            "givenName": "Irving L.", 
            "id": "sg:person.0767673555.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767673555.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA", 
              "id": "http://www.grid.ac/institutes/grid.5288.7", 
              "name": [
                "Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grompe", 
            "givenName": "Markus", 
            "id": "sg:person.01126164604.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126164604.61"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1016/s0925-5710(97)00057-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054664044", 
              "https://doi.org/10.1016/s0925-5710(97)00057-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/43919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027189945", 
              "https://doi.org/10.1038/43919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01535207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032702488", 
              "https://doi.org/10.1007/bf01535207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bmt.1702204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022605671", 
              "https://doi.org/10.1038/sj.bmt.1702204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35018642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006928495", 
              "https://doi.org/10.1038/35018642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02639395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018871122", 
              "https://doi.org/10.1007/bf02639395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0895-453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044553748", 
              "https://doi.org/10.1038/ng0895-453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/73179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034099380", 
              "https://doi.org/10.1038/73179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0296-198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008766623", 
              "https://doi.org/10.1038/nm0296-198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0396-266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043996615", 
              "https://doi.org/10.1038/ng0396-266"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2000-11", 
        "datePublishedReg": "2000-11-01", 
        "description": "The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH\u2212/\u2212 mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/81326", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "6"
          }
        ], 
        "keywords": [
          "hematopoietic stem cells", 
          "hematopoietic stem cell phenotype", 
          "stem cells", 
          "pluripotent hematopoietic cells", 
          "stem cell phenotype", 
          "germ layer origin", 
          "adult bone marrow cells", 
          "biochemical functions", 
          "primitive multipotent cells", 
          "multipotent cells", 
          "hematopoietic cells", 
          "progenitor cells", 
          "bone marrow cells", 
          "cell phenotype", 
          "hepatic progenitor cells", 
          "layer origin", 
          "marrow cells", 
          "cells", 
          "bone marrow", 
          "type I", 
          "tyrosinemia type I", 
          "phenotype", 
          "intravenous injection", 
          "animal models", 
          "hepatic regeneration", 
          "mice", 
          "clinical interest", 
          "vivo", 
          "regeneration", 
          "hepatocytes", 
          "liver", 
          "tissue", 
          "marrow", 
          "characterization", 
          "origin", 
          "function", 
          "ability", 
          "injection", 
          "rise", 
          "results", 
          "interest", 
          "questions", 
          "model", 
          "conventional assumption", 
          "assumption"
        ], 
        "name": "Purified hematopoietic stem cells can differentiate into hepatocytes in vivo", 
        "pagination": "1229-1234", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1039353607"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/81326"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "11062533"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/81326", 
          "https://app.dimensions.ai/details/publication/pub.1039353607"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:49", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_334.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/81326"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/81326'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/81326'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/81326'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/81326'


     

    This table displays all metadata directly associated to this object as RDF triples.

    277 TRIPLES      21 PREDICATES      96 URIs      79 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/81326 schema:about N0145962dbc8b4f54bd33e66097fa7b7b
    2 N1a3b44682202493fb06e1a516dafd72b
    3 N5e61276eba394ee0b62b20dff7cea38e
    4 N7933b09444cc4612bff1b9d5ba2ea504
    5 N811d8667f0714c48823eb87c3cbf8b5d
    6 N9117406846c043daa87ed22361e29ca9
    7 Naa7d96908d114593bad8e47077673eb6
    8 Nb9fc908bee504ce688ddaf109dfd6325
    9 Nba3f8cd2cfb74ada8b31659a6c2a9a71
    10 Nc200dba3dbc140f0b535355ff013e4aa
    11 Nc5b9663ea986428186f68f6c02062f56
    12 Ncc2afabe7c234b12ae797f0d80da627d
    13 Nce6e06e28c2f4e148bdfae2e239fcc90
    14 Ndb5ea22b56c340e49c4a726e2f5900c2
    15 Ndce790a5d004487bb7e4e90870b6ffc9
    16 Nf4f058efc9124c928fff1596ed6f1bc7
    17 anzsrc-for:11
    18 schema:author Nb53f6100cc3449d782adb0d8bea44a8b
    19 schema:citation sg:pub.10.1007/bf01535207
    20 sg:pub.10.1007/bf02639395
    21 sg:pub.10.1016/s0925-5710(97)00057-1
    22 sg:pub.10.1038/35018642
    23 sg:pub.10.1038/43919
    24 sg:pub.10.1038/73179
    25 sg:pub.10.1038/ng0396-266
    26 sg:pub.10.1038/ng0895-453
    27 sg:pub.10.1038/nm0296-198
    28 sg:pub.10.1038/sj.bmt.1702204
    29 schema:datePublished 2000-11
    30 schema:datePublishedReg 2000-11-01
    31 schema:description The characterization of hepatic progenitor cells is of great scientific and clinical interest. Here we report that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver. Moreover, within bone marrow, only rigorously purified hematopoietic stem cells gave rise to donor-derived hematopoietic and hepatic regeneration. This result seems to contradict the conventional assumptions of the germ layer origins of tissues such as the liver, and raises the question of whether the cells of the hematopoietic stem cell phenotype are pluripotent hematopoietic cells that retain the ability to transdifferentiate, or whether they are more primitive multipotent cells.
    32 schema:genre article
    33 schema:isAccessibleForFree false
    34 schema:isPartOf Na5af820191c34fa2a0c3abdffa9d9eb2
    35 Nbce05b71cd244621832a7df1504c6513
    36 sg:journal.1113716
    37 schema:keywords ability
    38 adult bone marrow cells
    39 animal models
    40 assumption
    41 biochemical functions
    42 bone marrow
    43 bone marrow cells
    44 cell phenotype
    45 cells
    46 characterization
    47 clinical interest
    48 conventional assumption
    49 function
    50 germ layer origin
    51 hematopoietic cells
    52 hematopoietic stem cell phenotype
    53 hematopoietic stem cells
    54 hepatic progenitor cells
    55 hepatic regeneration
    56 hepatocytes
    57 injection
    58 interest
    59 intravenous injection
    60 layer origin
    61 liver
    62 marrow
    63 marrow cells
    64 mice
    65 model
    66 multipotent cells
    67 origin
    68 phenotype
    69 pluripotent hematopoietic cells
    70 primitive multipotent cells
    71 progenitor cells
    72 questions
    73 regeneration
    74 results
    75 rise
    76 stem cell phenotype
    77 stem cells
    78 tissue
    79 type I
    80 tyrosinemia type I
    81 vivo
    82 schema:name Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    83 schema:pagination 1229-1234
    84 schema:productId Naa8f3a54155a4955962996eaa3814344
    85 Ncf551a212c43490ca713514bf40bd970
    86 Ne6c82c70c0af4ec7b3cec7dc4029a933
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039353607
    88 https://doi.org/10.1038/81326
    89 schema:sdDatePublished 2022-09-02T15:49
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher Nad1153726ac34bd281d5d700bff91692
    92 schema:url https://doi.org/10.1038/81326
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N0145962dbc8b4f54bd33e66097fa7b7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Mice, Inbred Strains
    98 rdf:type schema:DefinedTerm
    99 N0638b2fb850947729fa8300f5a8ab3bb rdf:first sg:person.01130627336.45
    100 rdf:rest N99aec6cdeb604e84ac48fe852aa2e3eb
    101 N0ae98a86e08b437ea64bbc67cac53568 rdf:first sg:person.01126164604.61
    102 rdf:rest rdf:nil
    103 N136c057e73ff4f4eb674fd7c2ede87d6 rdf:first sg:person.01203031110.54
    104 rdf:rest N6fba9c0abd7c4da9985e551262b73507
    105 N1a3b44682202493fb06e1a516dafd72b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Liver
    107 rdf:type schema:DefinedTerm
    108 N1ec1a5edbbdc40319dcbf0b7443f21e8 rdf:first sg:person.0767673555.64
    109 rdf:rest N0ae98a86e08b437ea64bbc67cac53568
    110 N4952d2e2e06f4640a1c5539735eadf06 rdf:first N5f44955e85d44f2bbe5cef598ce0b9f8
    111 rdf:rest N7dc7080babb44110a7dce10f77f21219
    112 N5e61276eba394ee0b62b20dff7cea38e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Hematopoietic Stem Cells
    114 rdf:type schema:DefinedTerm
    115 N5f44955e85d44f2bbe5cef598ce0b9f8 schema:affiliation grid-institutes:grid.422597.f
    116 schema:familyName Connors
    117 schema:givenName Heather
    118 rdf:type schema:Person
    119 N6fba9c0abd7c4da9985e551262b73507 rdf:first sg:person.0715517620.88
    120 rdf:rest Ned6d4be869a945fd834d21d68786fd72
    121 N7933b09444cc4612bff1b9d5ba2ea504 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Mice, Inbred C57BL
    123 rdf:type schema:DefinedTerm
    124 N7dc7080babb44110a7dce10f77f21219 rdf:first sg:person.015321277547.53
    125 rdf:rest N136c057e73ff4f4eb674fd7c2ede87d6
    126 N811d8667f0714c48823eb87c3cbf8b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Liver Regeneration
    128 rdf:type schema:DefinedTerm
    129 N9117406846c043daa87ed22361e29ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Mice
    131 rdf:type schema:DefinedTerm
    132 N99aec6cdeb604e84ac48fe852aa2e3eb rdf:first sg:person.014103516477.24
    133 rdf:rest N1ec1a5edbbdc40319dcbf0b7443f21e8
    134 Na5af820191c34fa2a0c3abdffa9d9eb2 schema:issueNumber 11
    135 rdf:type schema:PublicationIssue
    136 Naa7d96908d114593bad8e47077673eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Cell Differentiation
    138 rdf:type schema:DefinedTerm
    139 Naa8f3a54155a4955962996eaa3814344 schema:name doi
    140 schema:value 10.1038/81326
    141 rdf:type schema:PropertyValue
    142 Nad1153726ac34bd281d5d700bff91692 schema:name Springer Nature - SN SciGraph project
    143 rdf:type schema:Organization
    144 Nb53f6100cc3449d782adb0d8bea44a8b rdf:first sg:person.01315133635.01
    145 rdf:rest N4952d2e2e06f4640a1c5539735eadf06
    146 Nb9fc908bee504ce688ddaf109dfd6325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Hepatocytes
    148 rdf:type schema:DefinedTerm
    149 Nba3f8cd2cfb74ada8b31659a6c2a9a71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Whole-Body Irradiation
    151 rdf:type schema:DefinedTerm
    152 Nbce05b71cd244621832a7df1504c6513 schema:volumeNumber 6
    153 rdf:type schema:PublicationVolume
    154 Nc200dba3dbc140f0b535355ff013e4aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Hydrolases
    156 rdf:type schema:DefinedTerm
    157 Nc5b9663ea986428186f68f6c02062f56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Tyrosinemias
    159 rdf:type schema:DefinedTerm
    160 Ncc2afabe7c234b12ae797f0d80da627d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Cell Transplantation
    162 rdf:type schema:DefinedTerm
    163 Nce6e06e28c2f4e148bdfae2e239fcc90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Mice, Knockout
    165 rdf:type schema:DefinedTerm
    166 Ncf551a212c43490ca713514bf40bd970 schema:name pubmed_id
    167 schema:value 11062533
    168 rdf:type schema:PropertyValue
    169 Ndb5ea22b56c340e49c4a726e2f5900c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Animals
    171 rdf:type schema:DefinedTerm
    172 Ndce790a5d004487bb7e4e90870b6ffc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Cell Separation
    174 rdf:type schema:DefinedTerm
    175 Ne6c82c70c0af4ec7b3cec7dc4029a933 schema:name dimensions_id
    176 schema:value pub.1039353607
    177 rdf:type schema:PropertyValue
    178 Ned6d4be869a945fd834d21d68786fd72 rdf:first sg:person.01250211075.02
    179 rdf:rest N0638b2fb850947729fa8300f5a8ab3bb
    180 Nf4f058efc9124c928fff1596ed6f1bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Bone Marrow Cells
    182 rdf:type schema:DefinedTerm
    183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    184 schema:name Medical and Health Sciences
    185 rdf:type schema:DefinedTerm
    186 sg:journal.1113716 schema:issn 1078-8956
    187 1546-170X
    188 schema:name Nature Medicine
    189 schema:publisher Springer Nature
    190 rdf:type schema:Periodical
    191 sg:person.01126164604.61 schema:affiliation grid-institutes:grid.5288.7
    192 schema:familyName Grompe
    193 schema:givenName Markus
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126164604.61
    195 rdf:type schema:Person
    196 sg:person.01130627336.45 schema:affiliation grid-institutes:grid.5288.7
    197 schema:familyName Wang
    198 schema:givenName Xin
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130627336.45
    200 rdf:type schema:Person
    201 sg:person.01203031110.54 schema:affiliation grid-institutes:grid.422597.f
    202 schema:familyName Reitsma
    203 schema:givenName Michael
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203031110.54
    205 rdf:type schema:Person
    206 sg:person.01250211075.02 schema:affiliation grid-institutes:grid.422597.f
    207 schema:familyName Osborne
    208 schema:givenName Linda
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250211075.02
    210 rdf:type schema:Person
    211 sg:person.01315133635.01 schema:affiliation grid-institutes:grid.422597.f
    212 schema:familyName Lagasse
    213 schema:givenName Eric
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315133635.01
    215 rdf:type schema:Person
    216 sg:person.014103516477.24 schema:affiliation grid-institutes:grid.39382.33
    217 schema:familyName Finegold
    218 schema:givenName Milton
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014103516477.24
    220 rdf:type schema:Person
    221 sg:person.015321277547.53 schema:affiliation grid-institutes:grid.5288.7
    222 schema:familyName Al-Dhalimy
    223 schema:givenName Muhsen
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015321277547.53
    225 rdf:type schema:Person
    226 sg:person.0715517620.88 schema:affiliation grid-institutes:grid.422597.f
    227 schema:familyName Dohse
    228 schema:givenName Monika
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715517620.88
    230 rdf:type schema:Person
    231 sg:person.0767673555.64 schema:affiliation grid-institutes:grid.168010.e
    232 schema:familyName Weissman
    233 schema:givenName Irving L.
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767673555.64
    235 rdf:type schema:Person
    236 sg:pub.10.1007/bf01535207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032702488
    237 https://doi.org/10.1007/bf01535207
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1007/bf02639395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018871122
    240 https://doi.org/10.1007/bf02639395
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1016/s0925-5710(97)00057-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054664044
    243 https://doi.org/10.1016/s0925-5710(97)00057-1
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/35018642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006928495
    246 https://doi.org/10.1038/35018642
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/43919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027189945
    249 https://doi.org/10.1038/43919
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/73179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034099380
    252 https://doi.org/10.1038/73179
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1038/ng0396-266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043996615
    255 https://doi.org/10.1038/ng0396-266
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1038/ng0895-453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044553748
    258 https://doi.org/10.1038/ng0895-453
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1038/nm0296-198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008766623
    261 https://doi.org/10.1038/nm0296-198
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1038/sj.bmt.1702204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022605671
    264 https://doi.org/10.1038/sj.bmt.1702204
    265 rdf:type schema:CreativeWork
    266 grid-institutes:grid.168010.e schema:alternateName Department of Pathology and Developmental Biology Stanford University School of Medicine, 94305, Stanford, California, USA
    267 schema:name Department of Pathology and Developmental Biology Stanford University School of Medicine, 94305, Stanford, California, USA
    268 rdf:type schema:Organization
    269 grid-institutes:grid.39382.33 schema:alternateName Department of Pathology, Texas Children's Hospital Baylor College of Medicine, 77030, Houston, Texas, USA
    270 schema:name Department of Pathology, Texas Children's Hospital Baylor College of Medicine, 77030, Houston, Texas, USA
    271 rdf:type schema:Organization
    272 grid-institutes:grid.422597.f schema:alternateName StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA
    273 schema:name StemCells, 525 Del Rey Avenue, Suite C, 94085, Sunnyvale, California, USA
    274 rdf:type schema:Organization
    275 grid-institutes:grid.5288.7 schema:alternateName Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA
    276 schema:name Department of Molecular and Medical Genetics, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L103, 97201, Portland, Oregon, USA
    277 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...