Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

You-Wei Peng, Ying Hao, Robert M. Petters, Fulton Wong

ABSTRACT

In addition to rod photoreceptor loss, many mutations in rod photoreceptor-specific genes cause degeneration of other neuronal types. Identifying mechanisms of cell–cell interactions initiated by rod-specific mutations and affecting other retinal cells is important for understanding the pathogenesis and progression of retinal degeneration. Here we show in animals with rod and cone degeneration due to mutations in the genes encoding rhodopsin and cGMP phosphodiesterase β-subunit (PDE-β) respectively, that rod bipolar cells received ectopic synapses from cones in the absence of rods. Thus, synaptic plasticity links certain rod-specific mutations to retina-wide structural alterations that involve different types of neurons. More... »

PAGES

1121-1127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/80639

DOI

http://dx.doi.org/10.1038/80639

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049247362

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11036269


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