Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Yukio Horikawa, Naohisa Oda, Nancy J. Cox, Xiangquan Li, Marju Orho-Melander, Manami Hara, Yoshinori Hinokio, Tom H. Lindner, Hirosato Mashima, Peter E.H. Schwarz, Laura del Bosque-Plata, Yohko Horikawa, Yukie Oda, Issei Yoshiuchi, Susan Colilla, Kenneth S. Polonsky, Shan Wei, Patrick Concannon, Naoko Iwasaki, Jan Schulze, Leslie J. Baier, Clifton Bogardus, Leif Groop, Eric Boerwinkle, Craig L. Hanis, Graeme I. Bell

ABSTRACT

Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes. More... »

PAGES

ng1000_163

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    2

    VOLUME

    26

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/79876

    DOI

    http://dx.doi.org/10.1038/79876

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050773546

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11017071


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