A critical role for interleukin 4 in activating alloreactive CD4 T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-09

AUTHORS

Jessamyn Bagley, Tokihiko Sawada, Yin Wu, John Iacomini

ABSTRACT

To generate antigen-specific responses, T cells and antigen presenting cells (APCs) must physically associate with each other and elaborate soluble factors that drive the full differentiation of each cell type. Immediately after T cell activation, CD4 T cells can produce both interferon γ (IFN-γ) and interleukin 4 (IL-4) before polarization into distinct T helper subsets. Inhibition of IL-4 during mixed allogeneic lymphocyte culture resulted in a defect in the ability of APCs to generate sufficient costimulatory signals for activation of alloreactive T cells. In vivo, a deficiency in IL-4 production inhibited the activation of alloreactive IL-2–, IL-4– and IFN-γ–producing CD4 T cells in mice challenged with allogeneic skin grafts, resulting in prolonged skin graft survival. Thus, production of IL-4 by CD4 T cells helps activate alloreactive T cells by affecting APC function. More... »

PAGES

257-261

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/79811

DOI

http://dx.doi.org/10.1038/79811

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051126031

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10973285


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