Control of pre-T cell proliferation and differentiation by the GTPase Rac-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Manuel Gomez, Victor Tybulewicz, Doreen A. Cantrell

ABSTRACT

The GTPase Rac-I has the potential for pleiotropic functions due to its ability to interact with multiple effectors. Here, activation of Rac-I is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) beta selection. An activated Rac-I effector domain mutant that restricts signaling to particular actions on actin dynamics can drive pre-T cell differentiation. Rac-I activation cannot fully substitute for the pre-TCR complex but can fully correct defects in pre-T cell development in mice lacking the adapter molecule Vav-1. The present study identifies the subset of Rac-I responses that mediate Vav-1 action as critical regulators of TCR beta selection. More... »

PAGES

348

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/79808

DOI

http://dx.doi.org/10.1038/79808

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023701526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11017108


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