Ontology type: schema:ScholarlyArticle
2000-09
AUTHORSLisa M. Toney, Giorgio Cattoretti, Jennifer A. Graf, Taha Merghoub, Pier-Paolo Pandolfi, Riccardo Dalla-Favera, B. Hilda Ye, Alexander L. Dent
ABSTRACTThe transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity. More... »
PAGESni0900_214
http://scigraph.springernature.com/pub.10.1038/79749
DOIhttp://dx.doi.org/10.1038/79749
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1016868275
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/10973278
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemokine CCL2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemokine CCL7",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemokines, CC",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA-Binding Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Germinal Center",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Macrophages",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Knockout",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Monocyte Chemoattractant Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-bcl-6",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Th2 Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription, Genetic",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Indiana University \u2013 Purdue University Indianapolis",
"id": "https://www.grid.ac/institutes/grid.257413.6",
"name": [
"Department of Microbiology and Immunology and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis , IN 46202 and the Walther Cancer Institute , Indianapolis, IN 46208, USA."
],
"type": "Organization"
},
"familyName": "Toney",
"givenName": "Lisa M.",
"id": "sg:person.01160117727.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160117727.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Columbia University",
"id": "https://www.grid.ac/institutes/grid.21729.3f",
"name": [
"Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York , NY 10032, USA."
],
"type": "Organization"
},
"familyName": "Cattoretti",
"givenName": "Giorgio",
"id": "sg:person.0613065151.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613065151.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Indiana University \u2013 Purdue University Indianapolis",
"id": "https://www.grid.ac/institutes/grid.257413.6",
"name": [
"Department of Microbiology and Immunology and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis , IN 46202 and the Walther Cancer Institute , Indianapolis, IN 46208, USA."
],
"type": "Organization"
},
"familyName": "Graf",
"givenName": "Jennifer A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Human Genetics and Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA."
],
"type": "Organization"
},
"familyName": "Merghoub",
"givenName": "Taha",
"id": "sg:person.01046024744.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046024744.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"Department of Human Genetics and Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA."
],
"type": "Organization"
},
"familyName": "Pandolfi",
"givenName": "Pier-Paolo",
"id": "sg:person.01355745464.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355745464.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Columbia University",
"id": "https://www.grid.ac/institutes/grid.21729.3f",
"name": [
"Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York , NY 10032, USA."
],
"type": "Organization"
},
"familyName": "Dalla-Favera",
"givenName": "Riccardo",
"id": "sg:person.01143250520.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143250520.69"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Albert Einstein College of Medicine",
"id": "https://www.grid.ac/institutes/grid.251993.5",
"name": [
"Department of Cell Biology and Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA."
],
"type": "Organization"
},
"familyName": "Ye",
"givenName": "B. Hilda",
"id": "sg:person.01004275500.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004275500.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Indiana University \u2013 Purdue University Indianapolis",
"id": "https://www.grid.ac/institutes/grid.257413.6",
"name": [
"Department of Microbiology and Immunology and The Walther Oncology Center, Indiana University School of Medicine, Indianapolis , IN 46202 and the Walther Cancer Institute , Indianapolis, IN 46208, USA."
],
"type": "Organization"
},
"familyName": "Dent",
"givenName": "Alexander L.",
"id": "sg:person.0710606525.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710606525.36"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/0092-8674(92)90030-g",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007090770"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2222.1999.00006.x-i2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010567970"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2222.1999.00006.x-i2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010567970"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/360225a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011545272",
"https://doi.org/10.1038/360225a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.276.5312.589",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014082032"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/350423a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018596250",
"https://doi.org/10.1038/350423a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.95.23.13823",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019821245"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/08830189909088490",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022411448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/17.15.6419",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025252540"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35006097",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028656431",
"https://doi.org/10.1038/35006097"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35006097",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028656431",
"https://doi.org/10.1038/35006097"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/383787a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030311743",
"https://doi.org/10.1038/383787a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0993-66",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037798602",
"https://doi.org/10.1038/ng0993-66"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.19.10.7264",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041888703"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400631",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042048775",
"https://doi.org/10.1038/sj.leu.2400631"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.leu.2400631",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042048775",
"https://doi.org/10.1038/sj.leu.2400631"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/33340",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042374434",
"https://doi.org/10.1038/33340"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/33340",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042374434",
"https://doi.org/10.1038/33340"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.14.6947",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043597288"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0697-161",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047492526",
"https://doi.org/10.1038/ng0697-161"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.186.3.439",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049167524"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.135.1.279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049832070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/5.suppl_1.s55",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059393379"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.8235596",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062653730"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074262591",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.164.6.3009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074601215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.165.1.10",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074656341"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074669263",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082511149",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082511172",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jlb.56.4.514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082570246"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082670855",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082682826",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082893724",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082895244",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083040649",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083080273",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083084115",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083124316",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jlb.62.5.681",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083171492"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083191059",
"type": "CreativeWork"
}
],
"datePublished": "2000-09",
"datePublishedReg": "2000-09-01",
"description": "The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity.",
"genre": "research_article",
"id": "sg:pub.10.1038/79749",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2688347",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2467902",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2634276",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1022778",
"issn": [
"1529-2908",
"1529-2916"
],
"name": "Nature Immunology",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "1"
}
],
"name": "BCL-6 regulates chemokine gene transcription in macrophages",
"pagination": "ni0900_214",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"505eeb18d38d1165088b2609a06668172cc23429bcf27c14109dab282fabee68"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"10973278"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100941354"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/79749"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1016868275"
]
}
],
"sameAs": [
"https://doi.org/10.1038/79749",
"https://app.dimensions.ai/details/publication/pub.1016868275"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:26",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87112_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/articles/ni0900_214"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/79749'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/79749'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/79749'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/79749'
This table displays all metadata directly associated to this object as RDF triples.
314 TRIPLES
21 PREDICATES
85 URIs
40 LITERALS
28 BLANK NODES