BCL-6 regulates chemokine gene transcription in macrophages View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-09

AUTHORS

Lisa M. Toney, Giorgio Cattoretti, Jennifer A. Graf, Taha Merghoub, Pier-Paolo Pandolfi, Riccardo Dalla-Favera, B. Hilda Ye, Alexander L. Dent

ABSTRACT

The transcriptional repressor protein BCL-6, implicated in the pathogenesis of B cell lymphoma, regulates lymphocyte differentiation and inflammation. We investigated the mechanism for the T helper cell subset 2 (TH2)-type inflammation that occurs in BCL-6-/- mice. Using chimeric mice we found that the TH2-type inflammation is dependent upon nonlymphoid cells. We identified three chemokines, MCP-1, MCP-3 and MRP-1, which are negatively regulated by BCL-6 in macrophages. Promoter analysis revealed that BCL-6 is a potent repressor of MCP-1 transcription. Our results provide a mechanism for the regulation of TH2-type inflammation by BCL-6 and link TH2 differentiation to innate immunity. More... »

PAGES

ni0900_214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/79749

DOI

http://dx.doi.org/10.1038/79749

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10973278


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