T cell depletion in HIV-1 infection: how CD4+ T cells go out of stock View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-10

AUTHORS

Mette D. Hazenberg, Dörte Hamann, Hanneke Schuitemaker, Frank Miedema

ABSTRACT

HIV-1 infection is characterized by a gradual loss of CD4+ T cells and progressive immune deficiency that leads to opportunistic infections, otherwise rare malignancies and ultimately death. Extensive research over the past two decades has increased our insight into the pathogenic mechanisms underlying these features of HIV-1 infection. Here, we will give a brief overview of the most recent findings and present a model that fits most of the relevant aspects of HIV-1 infection as known. We hypothesize that HIV-1 infection depletes T cell supplies (which are not replaced because of low and static thymic function) by direct infection and killing of cells and through hyperactivation of the immune system. More... »

PAGES

285-289

References to SciGraph publications

  • 1997-05. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies in NATURE MEDICINE
  • 1993-03-25. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease in NATURE
  • 1995-01. Viral dynamics in human immunodeficiency virus type 1 infection in NATURE
  • 1998-07. Limited CD4+ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy in NATURE MEDICINE
  • 1998-02. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation in NATURE MEDICINE
  • 2000-02-01. Reconstitution of lymphocyte subpopulations after paediatric bone marrow transplantation in BONE MARROW TRANSPLANTATION
  • 1995-01. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection in NATURE
  • 1997-05. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection in NATURE
  • 1997-05. T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host in NATURE MEDICINE
  • 2000-09. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection in NATURE MEDICINE
  • 1998-12. Changes in thymic function with age and during the treatment of HIV infection in NATURE
  • 1999-09-01. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/79724

    DOI

    http://dx.doi.org/10.1038/79724

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014205434

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11017098


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