Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-09

AUTHORS

Mette D. Hazenberg, Sigrid A. Otto, James W.T. Cohen Stuart, Martie C.M. Verschuren, Jan C.C. Borleffs, Charles A.B. Boucher, Roel A. Coutinho, Joep M.A. Lange, Tobias F. Rinke de Wit, Aster Tsegaye, Jacques J.M. van Dongen, Dörte Hamann, Rob J. de Boer, Frank Miedema

ABSTRACT

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation. More... »

PAGES

1036-1042

Journal

TITLE

Nature Medicine

ISSUE

9

VOLUME

6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/79549

DOI

http://dx.doi.org/10.1038/79549

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015325579

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10973325


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