In vivo imaging of tumors with protease-activated near-infrared fluorescent probes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-04

AUTHORS

R Weissleder, C H Tung, U Mahmood, A Bogdanov

ABSTRACT

We have developed a method to image tumor-associated lysosomal protease activity in a xenograft mouse model in vivo using autoquenched near-infrared fluorescence (NIRF) probes. NIRF probes were bound to a long circulating graft copolymer consisting of poly-L-lysine and methoxypolyethylene glycol succinate. Following intravenous injection, the NIRF probe carrier accumulated in solid tumors due to its long circulation time and leakage through tumor neovasculature. Intratumoral NIRF signal was generated by lysosomal proteases in tumor cells that cleave the macromolecule, thereby releasing previously quenched fluorochrome. In vivo imaging showed a 12-fold increase in NIRF signal, allowing the detection of tumors with submillimeter-sized diameters. This strategy can be used to detect such early stage tumors in vivo and to probe for specific enzyme activity. More... »

PAGES

375-378

Journal

TITLE

Nature Biotechnology

ISSUE

4

VOLUME

17

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    URI

    http://scigraph.springernature.com/pub.10.1038/7933

    DOI

    http://dx.doi.org/10.1038/7933

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022752205

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10207887


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