Gene-expression profile of the ageing brain in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-07

AUTHORS

Cheol-Koo Lee, Richard Weindruch, Tomas A. Prolla

ABSTRACT

Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease (PD). Recent studies suggest that normal brain ageing is associated with subtle morphological and functional alterations in specific neuronal circuits, as opposed to large-scale neuronal loss1. In fact, ageing of the central nervous system in diverse mammalian species shares many features, such as atrophy of pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia2. To provide the first global analysis of brain ageing at the molecular level, we used oligonucleotide arrays representing 6,347 genes to determine the gene-expression profile of the ageing neocortex and cerebellum in mice. Ageing resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions. At the transcriptional level, brain ageing in mice displays parallels with human neurodegenerative disorders. Caloric restriction, which retards the ageing process in mammals, selectively attenuated the age-associated induction of genes encoding inflammatory and stress responses. More... »

PAGES

294-297

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/77046

DOI

http://dx.doi.org/10.1038/77046

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049898295

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10888876


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neocortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Stability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA", 
          "id": "http://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA", 
            "Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Cheol-Koo", 
        "id": "sg:person.01352142630.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352142630.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin, and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, Wisconsin, USA", 
          "id": "http://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Department of Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin, and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weindruch", 
        "givenName": "Richard", 
        "id": "sg:person.072376642.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072376642.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA", 
          "id": "http://www.grid.ac/institutes/grid.14003.36", 
          "name": [
            "Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prolla", 
        "givenName": "Tomas A.", 
        "id": "sg:person.012343334147.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343334147.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/4447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040686717", 
          "https://doi.org/10.1038/4447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00916410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016995955", 
          "https://doi.org/10.1007/bf00916410"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-07", 
    "datePublishedReg": "2000-07-01", 
    "description": "Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease (PD). Recent studies suggest that normal brain ageing is associated with subtle morphological and functional alterations in specific neuronal circuits, as opposed to large-scale neuronal loss1. In fact, ageing of the central nervous system in diverse mammalian species shares many features, such as atrophy of pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia2. To provide the first global analysis of brain ageing at the molecular level, we used oligonucleotide arrays representing 6,347 genes to determine the gene-expression profile of the ageing neocortex and cerebellum in mice. Ageing resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions. At the transcriptional level, brain ageing in mice displays parallels with human neurodegenerative disorders. Caloric restriction, which retards the ageing process in mammals, selectively attenuated the age-associated induction of genes encoding inflammatory and stress responses.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/77046", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2434698", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2473818", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "25"
      }
    ], 
    "keywords": [
      "gene expression profiles", 
      "Parkinson's disease", 
      "brain aging", 
      "Alzheimer's disease", 
      "age-associated induction", 
      "striatal dopamine receptors", 
      "major risk factor", 
      "common neurological disorder", 
      "central nervous system", 
      "normal brain aging", 
      "specific neuronal circuits", 
      "first global analysis", 
      "human neurodegenerative disorders", 
      "synaptic atrophy", 
      "pyramidal neurons", 
      "neurotrophic support", 
      "risk factors", 
      "inflammatory response", 
      "dopamine receptors", 
      "transcriptional level", 
      "nervous system", 
      "functional alterations", 
      "neuronal circuits", 
      "neurological disorders", 
      "species shares", 
      "brain regions", 
      "caloric restriction", 
      "neurodegenerative disorders", 
      "stress response", 
      "cytoskeletal abnormalities", 
      "oligonucleotide arrays", 
      "oxidative stress", 
      "molecular level", 
      "brain", 
      "atrophy", 
      "motor skills", 
      "fluorescent pigment", 
      "disease", 
      "mice", 
      "genes", 
      "disorders", 
      "global analysis", 
      "Recent studies", 
      "aging process", 
      "astrocytes", 
      "neocortex", 
      "mammals", 
      "abnormalities", 
      "cerebellum", 
      "neurons", 
      "impairment", 
      "response", 
      "receptors", 
      "aging", 
      "levels", 
      "alterations", 
      "induction", 
      "profile", 
      "pigments", 
      "accumulation", 
      "factors", 
      "decrease", 
      "study", 
      "stress", 
      "region", 
      "restriction", 
      "support", 
      "skills", 
      "analysis", 
      "features", 
      "array", 
      "process", 
      "parallel", 
      "fact", 
      "system", 
      "circuit", 
      "share", 
      "large-scale neuronal loss1", 
      "neuronal loss1", 
      "loss1", 
      "diverse mammalian species shares", 
      "mammalian species shares", 
      "microglia2", 
      "mice displays parallels", 
      "displays parallels"
    ], 
    "name": "Gene-expression profile of the ageing brain in mice", 
    "pagination": "294-297", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049898295"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/77046"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10888876"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/77046", 
      "https://app.dimensions.ai/details/publication/pub.1049898295"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_345.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/77046"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/77046'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/77046'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/77046'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/77046'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      22 PREDICATES      127 URIs      115 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/77046 schema:about N0e529f54fea741ba9ada055574f4cc74
2 N22e8d288cb1849a6a95b55868fe4084d
3 N311ff9c378cd40689b605998e77a1e62
4 N51795451c8614f1e9cde354d606d603d
5 N63c172775635416b9c3da4c91800a1d7
6 N65eafe802ac946b5a2cc3a4d5510f405
7 N69aa6ec8e050413e8f888567ae8301ff
8 N839f122300bc4b78a7390572952a78bf
9 N91ad5c3685c94088ba8b580c9f865f0e
10 Nc9075e68adc049a390cedcd380038a7a
11 Ndae5600e3fb6461fb1f21f4101d66654
12 anzsrc-for:06
13 anzsrc-for:0604
14 anzsrc-for:11
15 anzsrc-for:1109
16 schema:author N34e6014849864ca981cf5e518ecec1e3
17 schema:citation sg:pub.10.1007/bf00916410
18 sg:pub.10.1038/4447
19 schema:datePublished 2000-07
20 schema:datePublishedReg 2000-07-01
21 schema:description Ageing of the brain leads to impairments in cognitive and motor skills, and is the major risk factor for several common neurological disorders such as Alzheimer disease (AD) and Parkinson disease (PD). Recent studies suggest that normal brain ageing is associated with subtle morphological and functional alterations in specific neuronal circuits, as opposed to large-scale neuronal loss1. In fact, ageing of the central nervous system in diverse mammalian species shares many features, such as atrophy of pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia2. To provide the first global analysis of brain ageing at the molecular level, we used oligonucleotide arrays representing 6,347 genes to determine the gene-expression profile of the ageing neocortex and cerebellum in mice. Ageing resulted in a gene-expression profile indicative of an inflammatory response, oxidative stress and reduced neurotrophic support in both brain regions. At the transcriptional level, brain ageing in mice displays parallels with human neurodegenerative disorders. Caloric restriction, which retards the ageing process in mammals, selectively attenuated the age-associated induction of genes encoding inflammatory and stress responses.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree false
25 schema:isPartOf Nb120e277e19440938c13c923582efc89
26 Nf02b3ec134df4379bbf6ce0e68e66d52
27 sg:journal.1103138
28 schema:keywords Alzheimer's disease
29 Parkinson's disease
30 Recent studies
31 abnormalities
32 accumulation
33 age-associated induction
34 aging
35 aging process
36 alterations
37 analysis
38 array
39 astrocytes
40 atrophy
41 brain
42 brain aging
43 brain regions
44 caloric restriction
45 central nervous system
46 cerebellum
47 circuit
48 common neurological disorder
49 cytoskeletal abnormalities
50 decrease
51 disease
52 disorders
53 displays parallels
54 diverse mammalian species shares
55 dopamine receptors
56 fact
57 factors
58 features
59 first global analysis
60 fluorescent pigment
61 functional alterations
62 gene expression profiles
63 genes
64 global analysis
65 human neurodegenerative disorders
66 impairment
67 induction
68 inflammatory response
69 large-scale neuronal loss1
70 levels
71 loss1
72 major risk factor
73 mammalian species shares
74 mammals
75 mice
76 mice displays parallels
77 microglia2
78 molecular level
79 motor skills
80 neocortex
81 nervous system
82 neurodegenerative disorders
83 neurological disorders
84 neuronal circuits
85 neuronal loss1
86 neurons
87 neurotrophic support
88 normal brain aging
89 oligonucleotide arrays
90 oxidative stress
91 parallel
92 pigments
93 process
94 profile
95 pyramidal neurons
96 receptors
97 region
98 response
99 restriction
100 risk factors
101 share
102 skills
103 species shares
104 specific neuronal circuits
105 stress
106 stress response
107 striatal dopamine receptors
108 study
109 support
110 synaptic atrophy
111 system
112 transcriptional level
113 schema:name Gene-expression profile of the ageing brain in mice
114 schema:pagination 294-297
115 schema:productId N3c7886541e434941ad811419825aeda0
116 Nbc8b0430b4324030909ec64770c38ea5
117 Nc93ee0b4ba624888a9577fc2a1d480f0
118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049898295
119 https://doi.org/10.1038/77046
120 schema:sdDatePublished 2022-01-01T18:11
121 schema:sdLicense https://scigraph.springernature.com/explorer/license/
122 schema:sdPublisher N791be32da8f24667b2280cc7738b7a7e
123 schema:url https://doi.org/10.1038/77046
124 sgo:license sg:explorer/license/
125 sgo:sdDataset articles
126 rdf:type schema:ScholarlyArticle
127 N0e529f54fea741ba9ada055574f4cc74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name RNA Stability
129 rdf:type schema:DefinedTerm
130 N22e8d288cb1849a6a95b55868fe4084d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name RNA, Messenger
132 rdf:type schema:DefinedTerm
133 N311ff9c378cd40689b605998e77a1e62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Mice
135 rdf:type schema:DefinedTerm
136 N34e6014849864ca981cf5e518ecec1e3 rdf:first sg:person.01352142630.36
137 rdf:rest Nfc63de5f8b8b48bcac2a44ec7be62709
138 N3c7886541e434941ad811419825aeda0 schema:name pubmed_id
139 schema:value 10888876
140 rdf:type schema:PropertyValue
141 N51795451c8614f1e9cde354d606d603d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neocortex
143 rdf:type schema:DefinedTerm
144 N63c172775635416b9c3da4c91800a1d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Cerebellum
146 rdf:type schema:DefinedTerm
147 N65eafe802ac946b5a2cc3a4d5510f405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Mice, Inbred C57BL
149 rdf:type schema:DefinedTerm
150 N69aa6ec8e050413e8f888567ae8301ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Gene Expression
152 rdf:type schema:DefinedTerm
153 N6dca6abe8a904694ad5408c5869a02d2 rdf:first sg:person.012343334147.74
154 rdf:rest rdf:nil
155 N791be32da8f24667b2280cc7738b7a7e schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N839f122300bc4b78a7390572952a78bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Aging
159 rdf:type schema:DefinedTerm
160 N91ad5c3685c94088ba8b580c9f865f0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Brain
162 rdf:type schema:DefinedTerm
163 Nb120e277e19440938c13c923582efc89 schema:issueNumber 3
164 rdf:type schema:PublicationIssue
165 Nbc8b0430b4324030909ec64770c38ea5 schema:name dimensions_id
166 schema:value pub.1049898295
167 rdf:type schema:PropertyValue
168 Nc9075e68adc049a390cedcd380038a7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Animals
170 rdf:type schema:DefinedTerm
171 Nc93ee0b4ba624888a9577fc2a1d480f0 schema:name doi
172 schema:value 10.1038/77046
173 rdf:type schema:PropertyValue
174 Ndae5600e3fb6461fb1f21f4101d66654 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Male
176 rdf:type schema:DefinedTerm
177 Nf02b3ec134df4379bbf6ce0e68e66d52 schema:volumeNumber 25
178 rdf:type schema:PublicationVolume
179 Nfc63de5f8b8b48bcac2a44ec7be62709 rdf:first sg:person.072376642.63
180 rdf:rest N6dca6abe8a904694ad5408c5869a02d2
181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biological Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
185 schema:name Genetics
186 rdf:type schema:DefinedTerm
187 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
188 schema:name Medical and Health Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
191 schema:name Neurosciences
192 rdf:type schema:DefinedTerm
193 sg:grant.2434698 http://pending.schema.org/fundedItem sg:pub.10.1038/77046
194 rdf:type schema:MonetaryGrant
195 sg:grant.2473818 http://pending.schema.org/fundedItem sg:pub.10.1038/77046
196 rdf:type schema:MonetaryGrant
197 sg:journal.1103138 schema:issn 1061-4036
198 1546-1718
199 schema:name Nature Genetics
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.012343334147.74 schema:affiliation grid-institutes:grid.14003.36
203 schema:familyName Prolla
204 schema:givenName Tomas A.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012343334147.74
206 rdf:type schema:Person
207 sg:person.01352142630.36 schema:affiliation grid-institutes:grid.14003.36
208 schema:familyName Lee
209 schema:givenName Cheol-Koo
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352142630.36
211 rdf:type schema:Person
212 sg:person.072376642.63 schema:affiliation grid-institutes:grid.14003.36
213 schema:familyName Weindruch
214 schema:givenName Richard
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072376642.63
216 rdf:type schema:Person
217 sg:pub.10.1007/bf00916410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016995955
218 https://doi.org/10.1007/bf00916410
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/4447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040686717
221 https://doi.org/10.1038/4447
222 rdf:type schema:CreativeWork
223 grid-institutes:grid.14003.36 schema:alternateName Department of Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin, and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, Wisconsin, USA
224 Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA
225 schema:name Department of Medicine and Wisconsin Regional Primate Research Center, University of Wisconsin, and Veterans Administration Hospital, Geriatric Research, Education and Clinical Center, Madison, Wisconsin, USA
226 Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, Wisconsin, USA
227 Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...