Conformation of the myosin motor during force generation in skeletal muscle View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-06-01

AUTHORS

Malcolm Irving, Gabriella Piazzesi, Leonardo Lucii, Yin-Biao Sun, Jeffrey J. Harford, Ian M. Dobbie, Michael A. Ferenczi, Massimo Reconditi, Vincenzo Lombardi

ABSTRACT

Myosin motors drive muscle contraction, cytokinesis and cell locomotion, and members of the myosin superfamily have been implicated in an increasingly diverse range of cell functions. Myosin can displace a bound actin filament several nanometers in a single interaction. Crystallographic studies suggest that this ‘working stroke’ involves bending of the myosin head between its light chain and catalytic domains. Here we used X-ray fiber diffraction to test the crystallographic model and measure the interdomain bending during force generation in an intact single muscle fiber. The observed bending has two components: an elastic distortion and an active rotation that generates force. The average bend of the force-generating myosin heads in a muscle fiber is intermediate between those in crystal structures with different bound nucleotides, and the C-terminus of the head is displaced by 7 nm along the actin filament axis compared with the in vitro conformation seen in the absence of nucleotide. More... »

PAGES

482-485

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/75890

DOI

http://dx.doi.org/10.1038/75890

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034832169

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10881196


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