Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

Benjamin E. Reubinoff, Martin F. Pera, Chui-Yee Fong, Alan Trounson, Ariff Bongso

ABSTRACT

We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of pluripotent primate cells. Human ES cells express the transcription factor Oct-4, essential for development of pluripotential cells in the mouse. When grafted into SCID mice, both lines give rise to teratomas containing derivatives of all three embryonic germ layers. Both cell lines differentiate in vitro into extraembryonic and somatic cell lineages. Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons. Embryonic stem cells provide a model to study early human embryology, an investigational tool for discovery of novel growth factors and medicines, and a potential source of cells for use in transplantation therapy. More... »

PAGES

nbt0400_399

Journal

TITLE

Nature Biotechnology

ISSUE

4

VOLUME

18

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/74447

    DOI

    http://dx.doi.org/10.1038/74447

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033604670

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10748519


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