Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-04

AUTHORS

K Lindblad-Toh, E Winchester, M J Daly, D G Wang, J N Hirschhorn, J P Laviolette, K Ardlie, D E Reich, E Robinson, P Sklar, N Shah, D Thomas, J B Fan, T Gingeras, J Warrington, N Patil, T J Hudson, E S Lander

ABSTRACT

Single-nucleotide polymorphisms (SNPs) have been the focus of much attention in human genetics because they are extremely abundant and well-suited for automated large-scale genotyping. Human SNPs, however, are less informative than other types of genetic markers (such as simple-sequence length polymorphisms or microsatellites) and thus more loci are required for mapping traits. SNPs offer similar advantages for experimental genetic organisms such as the mouse, but they entail no loss of informativeness because bi-allelic markers are fully informative in analysing crosses between inbred strains. Here we report a large-scale analysis of SNPs in the mouse genome. We characterized the rate of nucleotide polymorphism in eight mouse strains and identified a collection of 2,848 SNPs located in 1,755 sequence-tagged sites (STSs) using high-density oligonucleotide arrays. Three-quarters of these SNPs have been mapped on the mouse genome, providing a first-generation SNP map of the mouse. We have also developed a multiplex genotyping procedure by which a genome scan can be performed with only six genotyping reactions per animal. More... »

PAGES

381-386

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/74215

DOI

http://dx.doi.org/10.1038/74215

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001732089

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10742102


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