Clinical applications of angiogenic growth factors and their inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

N Ferrara, K Alitalo

ABSTRACT

Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials. More... »

PAGES

1359-1364

References to SciGraph publications

  • 1996-04. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene in NATURE
  • 1996-12. The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells in NATURE MEDICINE
  • 1999-06. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation in NATURE MEDICINE
  • 1995-10. Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis in NATURE MEDICINE
  • 1998-01. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator in NATURE
  • 1998-03. Vascular endothelial growth factor is essential for corpus luteum angiogenesis in NATURE MEDICINE
  • 1993-04. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo in NATURE
  • 1998-07. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis in NATURE
  • 1997-04. Mechanisms of angiogenesis in NATURE
  • 1998-07. Angiogenesis and Vasculogenesis in Treatment of Cardiovascular Disease in MOLECULAR MEDICINE
  • 1996-05. Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart in NATURE MEDICINE
  • 1999-04. Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector in NATURE MEDICINE
  • 1996-04. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele in NATURE
  • 1999-04. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization in NATURE MEDICINE
  • 1995-01. Angiogenesis in cancer, vascular, rheumatoid and other disease in NATURE MEDICINE
  • 1999-05. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 in NATURE MEDICINE
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    12

    VOLUME

    5

    Related Patents

  • Enzyme Inhibiting Compounds
  • Use Of Vegf And Homologues To Treat Neuron Disorders
  • Stable Crystalline Polymorphs Of The Dipotassium Salt Of (S) -2- {4- [2- (2, 4-Diamin0-Quinaz0lin-6-Yl) -Ethyl] -Benzoylamino} -4-Methylenξ-Penta Nedioic Acid
  • Depsipeptides And Their Therapeutic Use
  • Therapy Targeting Flt4 (Veger-3) Expressed In Blood Vessels
  • Eg-Vegf Nucleic Acids And Polypeptides And Method Of Use
  • Inhibition Of Abnormal Cell Proliferation With Camptothecin And Combinations Including The Same
  • Method For Determining Haemodynamic Indices By Use Of Tomographic Data
  • Therapeutic Method For Reducing Angiogenesis
  • Scriptaid Isosteres And Their Use In Therapy
  • Multispecific Antibodies
  • 4,6-Diamino-Pyrido[3,2-D]Pyrimidine Derivaties As Toll Like Receptor Modulators
  • Benzimidazole Derivatives And Their Use As Phosphatidylinositol 3-Kinase Inhibitors
  • Benzimidazole Derivatives And Their Use As Phosphatidylinositol 3-Kinase Inhibitors
  • Anti-Vegf Antibodies
  • Phosphatidylinositol 3-Kinase Inhibitors
  • Carboline Derivatives Useful In The Inhibition Of Angiogenesis
  • Phosphatidylinositol 3-Kinase Inhibitors
  • Dipeptidyl Peptidase Inhibitors
  • Anti-Vegf-C Antibodies And Methods Using Same
  • Eg-Vegf Nucleic Acids And Polypeptides And Methods Of Use
  • Combination Therapies For Treating B-Cell Malignancies
  • Toll-Like Receptor Modulating 4,6-Diamino-Pyrido[3,2-D]Pyrimidine Compounds
  • Methods For Selective Targeting
  • Anti-Vegf Antibodies
  • Medical Hyperspectral Imaging For Evaluation Of Tissue And Tumor
  • Neuropilin Antagonists
  • Combination Of A Btk Inhibitor And A Checkpoint Inhibitor For Treating Cancers
  • Pi3k/M Tor Inhibitors
  • Multispecific Antibodies
  • Binding Polypeptides And Uses Thereof
  • Methods For Detecting Targets
  • Hyperspectral Imaging In Diabetes And Peripheral Vascular Disease
  • Vascular Endothelial Growth Factor C (Vegf-C) Protein And Gene, Mutants Thereof, And Uses Thereof
  • Therapies For Treating Cancers
  • Method Of Treating Eye Disease Using Glycosylated Vegf Decoy Receptor Fusion Protein
  • Eg-Vegf Nucleic Acids And Polypeptides And Methods Of Use
  • Optimized Variants Of Anti-Vegf Antibodies And Methods Of Treatment Thereof By Reducing Or Inhibiting Angiogenesis
  • Process For Preparing Phosphatidylinositol 3-Kinase Inhibitors And Intermediates Thereof
  • Hyperspectral Technology For Assessing And Treating Diabetic Foot And Tissue Disease
  • 4,6-Diamino-Pyrido[3,2-D]Pyrimidine Compounds And Their Utilisation As Modulators Of Toll-Like Receptors
  • Toll Like Receptor Modulator Compounds
  • Anti-Angiogenic Therapy
  • Anti-Vegf Antibodies
  • Materials And Methods Involving Hybrid Vascular Endothelial Growth Factor Dnas And Proteins
  • Anti-Vegf-C Antibodies And Methods Using Same
  • Anti-Angiogenesis Therapy For The Treatment Of Ovarian Cancer
  • Histone Deacetylase Inhibitors And Their Use In Therapy
  • Vascular Endothelial Growth Factor C (Vegf-C) Protein And Gene, Mutants Thereof, And Uses Thereof
  • Benzimidazole Derivatives And Their Use As Phosphatidylinositol 3-Kinase Inhibitors
  • Process Methods For Phosphatidylinositol 3-Kinase Inhibitors
  • Anti-Ox40 Antibodies And Methods Of Use
  • Antibody Formulations
  • Detection Of Activation Of Endothelial Cells As Surrogate Marker For Angiogenesis
  • Oncolytic Vaccinia Virus Combination Cancer Therapy
  • Eg-Vegf Nucleic Acids And Polypeptides And Methods Of Use
  • Eg-Vegf Nucleic Acids And Polypeptides And Methods Of Use
  • Anti-Vegf Antibodies
  • Bv8 Nucleic Acids And Polypeptides With Mitogenic Activity
  • Cyclic Peptides, Method For Preparing And Use As Angiogenesis Inhibitors Or Activator
  • Use Of Vegf-C Or Vegf-D Gene Or Protein To Prevent Restenosis
  • Glycosylated Vegf Decoy Receptor Fusion Protein
  • Anti-Bv8 Antibodies And Uses Thereof
  • Histone Deacetylase Inhibitors
  • Polymorphic Forms Of A Hydrochloride Salt Of (S)-2-(1-(9h-Purin-6-Ylamino)Propyl)-5-Fluoro-3-Phenylquinazolin-4(3h)-One
  • Methods And Compositions For Synaphically-Targeted Treatment For Cancer
  • Anti-Vegf Antibodies
  • Activin Receptor-Like Kinase-1 Compositions And Methods Of Use
  • Compositions Comprising Phosphoinositide 3-Kinase Inhibitors And A Second Antiproliferative Agent
  • Phosphatidylinositol 3-Kinase Inhibitors
  • Anti-Neuropilin Antibodies And Methods Of Use
  • Carboline Derivatives Useful In The Inhibition Of Angiogenesis
  • Methods And Compositions Inhibiting A Lysyl Oxidase (-Like) Protein For Treatment And Diagnosis Of Fibrosis, Tumor Invasion, Angiogenesis, And Metastasis
  • Novel Histone Deacetylase Inhibitors And Their Use In Therapy
  • Inhibition Of Vegf Translation
  • A Method Of Treating Cancer Comprising A Vegf-B Antagonist
  • Improving Trabeculectomy Outcome By Administering An Anti-Placental Growth Factor Antibody
  • Lymphatic Zip Codes In Tumors And Pre-Malignant Lesions
  • Anti-Vegf Antibodies
  • Materials And Methods Involving Hybrid Vascular Endothelial Growth Factor Dnas And Proteins
  • Carboline Derivatives Useful In The Treatment Of Cancer
  • Multispecific Antibodies
  • Medical Hyperspectral Imaging For Evaluation Of Tissue And Tumor
  • Bispecific Anti-Vegf/Anti-Ang-2 Antibodies And Their Use In The Treatment Of Ocular Vascular Diseases
  • Compositions Comprising A Pi3k Inhibitor And An Hdac Inhibitor
  • Use Of Vegf And Homologues To Treat Neuron Disorders
  • Carboline Derivatives Useful In The Inhibition Of Angiogenesis
  • Anti-Angiogenic Therapy
  • Treatment With Anti-Vegf Antibodies
  • N-(Cyanomethyl)-4-(2-(4-Morpholinophenylamino)Pyrimidin-4-Yl)Benzamide Hydrochloride Salts
  • Lox And Loxl2 Inhibitors Antibodies And Uses Thereof
  • Hyperspectral Imaging In Diabetes And Peripheral Vascular Disease
  • Administration Of Carboline Derivatives Useful In The Treatment Of Cancer And Other Diseases
  • Therapies For Treating Myeloproliferative Disorders
  • Hyperspectral Imaging Of Angiogenesis
  • Methods For Selective Targeting
  • Hyperspectral Imaging In Diabetes And Peripheral Vascular Disease
  • Use Of Vegf-C Or Vegf-D Gene Or Protein To Prevent Restenosis
  • Use Of Vegf-C Or Vegf-D Gene Or Protein To Prevent Restenosis
  • Antibody Fc Variants
  • Phosphatidylinositol 3-Kinase Inhibitors
  • Hyperspectral Technology For Assessing And Treating Diabetic Foot And Tissue Disease
  • Antibody Fc Variants
  • Anti-Bv8 Antibodies And Uses Thereof
  • Phosphatidylinositol 3-Kinase Inhibitors
  • Use Of Vegf-C Or Vegf-D Gene Or Protein To Prevent Restenosis
  • Methods For Selective Targeting
  • Hyperspectral Imaging In Diabetes And Peripheral Vascular Disease
  • Use Of Vegf-C Or Vegf-D Gene Or Protein To Prevent Restenosis
  • Anti-Vegf Antibodies
  • Process Methods For Phosphatidylinositol 3-Kinase Inhibitors
  • Cyclic Peptides, Method For Preparing And Use As Angiogenesis Inhibitors Or Activators
  • Hyperspectral Imaging Of Angiogenesis
  • Medical Hyperspectral Imaging For Evaluation Of Tissue And Tumor
  • Anti-Vegf Antibodies
  • Antifolate Compositions
  • Phosphatidylinositol 3-Kinase Inhibitors
  • Anti-Vegf Antibodies
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/70928

    DOI

    http://dx.doi.org/10.1038/70928

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049615868

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10581076


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Coronary Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelial Growth Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Growth Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ischemia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Physiologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinant Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retinal Vein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor A", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Department of Molecular Oncology Genentech DNA Way South San Francisco, California 94080, USA. nf@gene.com"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferrara", 
            "givenName": "N", 
            "type": "Person"
          }, 
          {
            "familyName": "Alitalo", 
            "givenName": "K", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81402-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000555694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/89.2.139", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000810733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0398-336", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001019213", 
              "https://doi.org/10.1038/nm0398-336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/07357909809039771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001211057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199610243351707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001445619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/dbio.1997.8639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001679701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.2.363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001756212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-5223(98)70455-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002070685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.15.8829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003453811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0596-534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004115692", 
              "https://doi.org/10.1038/nm0596-534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/380439a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004384986", 
              "https://doi.org/10.1038/380439a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.98.19.2081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005139885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(98)80321-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008827441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(98)80321-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008827441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0195-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008981922", 
              "https://doi.org/10.1038/nm0195-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1995.1194", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009132218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci117018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009887518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.47.31273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009905008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/386671a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010094120", 
              "https://doi.org/10.1038/386671a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.83.3.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011213963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041433-199704000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011304900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00041433-199704000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011304900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(96)03361-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011642904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/362841a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013132150", 
              "https://doi.org/10.1038/362841a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/7434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013556778", 
              "https://doi.org/10.1038/7434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/7434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013556778", 
              "https://doi.org/10.1038/7434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0177(199708)209:4<418::aid-aja9>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014132658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-3659(97)00237-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014334783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1095-1085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015306666", 
              "https://doi.org/10.1038/nm1095-1085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci6740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016003327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/019262339902700115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016671596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/019262339902700115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016671596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81731-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017592303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199412013312203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018716626"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/7439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019073472", 
              "https://doi.org/10.1038/7439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/7439", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019073472", 
              "https://doi.org/10.1038/7439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19980417)79:2<144::aid-ijc8>3.0.co;2-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020532199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)65582-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020592852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/28867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020992380", 
              "https://doi.org/10.1038/28867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/28867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020992380", 
              "https://doi.org/10.1038/28867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.3.295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021864540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.97.12.1114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022909671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022991853", 
              "https://doi.org/10.1038/34193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022991853", 
              "https://doi.org/10.1038/34193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81010-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023555380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024593021", 
              "https://doi.org/10.1038/9467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/9467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024593021", 
              "https://doi.org/10.1038/9467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0741-5214(98)70022-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025541721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.92.23.10457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025801845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.4.882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027190331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.88.1.208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030356097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm197111182852108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031952402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci117521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032289300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.6.3071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033899749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/380435a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034005847", 
              "https://doi.org/10.1038/380435a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81436-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037220480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.15.8795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037720209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci117378", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037835837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archopht.1996.01100130062010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042755429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm197108122850711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042994614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0741-5214(98)70236-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043411175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.25.14765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045231712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119740", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045876259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/7.13.2073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046478479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.32.20556", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046707898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.97.4.381", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047156652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.98.25.2800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048432123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)93001-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048813911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)93001-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048813911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1296-1371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049266422", 
              "https://doi.org/10.1038/nm1296-1371"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(98)80137-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051213728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80154-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051350511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/8379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052764754", 
              "https://doi.org/10.1038/8379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.141.7.1659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053361197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0008-6363(98)00136-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054580102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.1997.8.15-1737", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059271929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.1998.9.10-1481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/hum.1998.9.6-823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059272311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.275.5302.964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062555783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.276.5317.1423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062556862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5388.468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.285.5433.1553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062566508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.91.11.2793", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063335927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.92.9.2463", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063336733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.92.9.365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063336789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/edrv.18.1.0287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064238390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074251153", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081594878", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.1994.267.4.h1263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082576665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082876818", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082876932", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082906666", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082937240", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082941424", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082983681", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.1996.270.5.h1803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083003118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083175627", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083235023", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083288691", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03401749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083308871", 
              "https://doi.org/10.1007/bf03401749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/6.1.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083452034"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1999-12", 
        "datePublishedReg": "1999-12-01", 
        "description": "Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/70928", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "5"
          }
        ], 
        "name": "Clinical applications of angiogenic growth factors and their inhibitors", 
        "pagination": "1359-1364", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ec5b1aed445b8e170cb80a076b8968b189dd736e8b040e455c945e9045af544b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "10581076"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/70928"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1049615868"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/70928", 
          "https://app.dimensions.ai/details/publication/pub.1049615868"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87094_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nm/journal/v5/n12/full/nm1299_1359.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/70928'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/70928'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/70928'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/70928'


     

    This table displays all metadata directly associated to this object as RDF triples.

    417 TRIPLES      21 PREDICATES      137 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/70928 schema:about N070130fb320643bba815b3d6e5d151a2
    2 N0ce23bc5aa8f47b49d57221371b848b1
    3 N0d0c2adb606144a6989f0906ea642490
    4 N0f20e94db95f40bbb52f803873af9eaf
    5 N127541f1276f4defafc060f62b60ac1e
    6 N17258ac21b354c3fbca023a1ad3e1a3a
    7 N212d6dac2bf64082b9037bc9d5f591e2
    8 N2efb84413da64065ac7b813ea5417604
    9 N42163ba068ed4bcc9ade8359a96978ae
    10 N5798c04f2a8f4bbd978cd14f1947fbd8
    11 N6e03f8aa012048c29d57c4eb64addef6
    12 N741c2db459154682a59f7f0a51eb31d4
    13 Nc3ea5c3dacb3456daa032fc337add75d
    14 Nc88817df33e742e2a6ef059802f97b63
    15 Ndd0e23cfc79d4c07bef1d7b7cba19975
    16 Ne55a9dc4077745f09dc549628c461a5f
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author Nb1348f19b57c469faeeb9c566bc83f4e
    20 schema:citation sg:pub.10.1007/bf03401749
    21 sg:pub.10.1038/28867
    22 sg:pub.10.1038/34193
    23 sg:pub.10.1038/362841a0
    24 sg:pub.10.1038/380435a0
    25 sg:pub.10.1038/380439a0
    26 sg:pub.10.1038/386671a0
    27 sg:pub.10.1038/7434
    28 sg:pub.10.1038/7439
    29 sg:pub.10.1038/8379
    30 sg:pub.10.1038/9467
    31 sg:pub.10.1038/nm0195-27
    32 sg:pub.10.1038/nm0398-336
    33 sg:pub.10.1038/nm0596-534
    34 sg:pub.10.1038/nm1095-1085
    35 sg:pub.10.1038/nm1296-1371
    36 https://app.dimensions.ai/details/publication/pub.1074251153
    37 https://app.dimensions.ai/details/publication/pub.1081594878
    38 https://app.dimensions.ai/details/publication/pub.1082876818
    39 https://app.dimensions.ai/details/publication/pub.1082876932
    40 https://app.dimensions.ai/details/publication/pub.1082906666
    41 https://app.dimensions.ai/details/publication/pub.1082937240
    42 https://app.dimensions.ai/details/publication/pub.1082941424
    43 https://app.dimensions.ai/details/publication/pub.1082983681
    44 https://app.dimensions.ai/details/publication/pub.1083175627
    45 https://app.dimensions.ai/details/publication/pub.1083235023
    46 https://app.dimensions.ai/details/publication/pub.1083288691
    47 https://doi.org/10.1001/archopht.1996.01100130062010
    48 https://doi.org/10.1002/(sici)1097-0177(199708)209:4<418::aid-aja9>3.0.co;2-l
    49 https://doi.org/10.1002/(sici)1097-0215(19980417)79:2<144::aid-ijc8>3.0.co;2-t
    50 https://doi.org/10.1006/bbrc.1995.1194
    51 https://doi.org/10.1006/dbio.1997.8639
    52 https://doi.org/10.1016/s0002-9440(10)65582-4
    53 https://doi.org/10.1016/s0008-6363(98)00136-9
    54 https://doi.org/10.1016/s0022-5223(98)70455-6
    55 https://doi.org/10.1016/s0092-8674(00)81010-7
    56 https://doi.org/10.1016/s0092-8674(00)81402-6
    57 https://doi.org/10.1016/s0092-8674(00)81436-1
    58 https://doi.org/10.1016/s0092-8674(00)81731-6
    59 https://doi.org/10.1016/s0140-6736(94)93001-5
    60 https://doi.org/10.1016/s0140-6736(96)03361-2
    61 https://doi.org/10.1016/s0168-3659(97)00237-x
    62 https://doi.org/10.1016/s0735-1097(98)80321-5
    63 https://doi.org/10.1016/s0741-5214(98)70022-9
    64 https://doi.org/10.1016/s0741-5214(98)70236-8
    65 https://doi.org/10.1016/s0955-0674(98)80137-3
    66 https://doi.org/10.1016/s1097-2765(00)80154-9
    67 https://doi.org/10.1056/nejm197108122850711
    68 https://doi.org/10.1056/nejm197111182852108
    69 https://doi.org/10.1056/nejm199412013312203
    70 https://doi.org/10.1056/nejm199610243351707
    71 https://doi.org/10.1073/pnas.92.23.10457
    72 https://doi.org/10.1073/pnas.93.25.14765
    73 https://doi.org/10.1073/pnas.95.15.8795
    74 https://doi.org/10.1073/pnas.95.15.8829
    75 https://doi.org/10.1073/pnas.96.6.3071
    76 https://doi.org/10.1074/jbc.273.32.20556
    77 https://doi.org/10.1074/jbc.273.47.31273
    78 https://doi.org/10.1083/jcb.141.7.1659
    79 https://doi.org/10.1089/hum.1997.8.15-1737
    80 https://doi.org/10.1089/hum.1998.9.10-1481
    81 https://doi.org/10.1089/hum.1998.9.6-823
    82 https://doi.org/10.1093/emboj/18.2.363
    83 https://doi.org/10.1093/emboj/18.4.882
    84 https://doi.org/10.1093/hmg/7.13.2073
    85 https://doi.org/10.1093/jnci/6.1.73
    86 https://doi.org/10.1093/jnci/89.2.139
    87 https://doi.org/10.1097/00041433-199704000-00004
    88 https://doi.org/10.1101/gad.13.3.295
    89 https://doi.org/10.1126/science.275.5302.964
    90 https://doi.org/10.1126/science.276.5317.1423
    91 https://doi.org/10.1126/science.282.5388.468
    92 https://doi.org/10.1126/science.285.5433.1553
    93 https://doi.org/10.1152/ajpheart.1994.267.4.h1263
    94 https://doi.org/10.1152/ajpheart.1996.270.5.h1803
    95 https://doi.org/10.1161/01.cir.88.1.208
    96 https://doi.org/10.1161/01.cir.91.11.2793
    97 https://doi.org/10.1161/01.cir.92.9.2463
    98 https://doi.org/10.1161/01.cir.92.9.365
    99 https://doi.org/10.1161/01.cir.97.12.1114
    100 https://doi.org/10.1161/01.cir.97.4.381
    101 https://doi.org/10.1161/01.cir.98.19.2081
    102 https://doi.org/10.1161/01.cir.98.25.2800
    103 https://doi.org/10.1161/01.res.83.3.233
    104 https://doi.org/10.1172/jci117018
    105 https://doi.org/10.1172/jci117378
    106 https://doi.org/10.1172/jci117521
    107 https://doi.org/10.1172/jci119740
    108 https://doi.org/10.1172/jci6740
    109 https://doi.org/10.1177/019262339902700115
    110 https://doi.org/10.1210/edrv.18.1.0287
    111 https://doi.org/10.3109/07357909809039771
    112 schema:datePublished 1999-12
    113 schema:datePublishedReg 1999-12-01
    114 schema:description Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis) is a an exciting frontier of cardiovascular medicine. Conversely, inhibition of the action of key regulators of angiogenesis, such as VEGF, constitutes a promising approach for the treatment of solid tumors and intraocular neovascular syndromes. These concepts are being tested now in clinical trials.
    115 schema:genre research_article
    116 schema:inLanguage en
    117 schema:isAccessibleForFree false
    118 schema:isPartOf N94080ac9b9f34921b90903ddd786d497
    119 Nbdd9c93e6ca24ff990652d54022a5efc
    120 sg:journal.1113716
    121 schema:name Clinical applications of angiogenic growth factors and their inhibitors
    122 schema:pagination 1359-1364
    123 schema:productId N1e89799f87e84f21a0fd1ef75066564c
    124 N474eb519cdbd4933ae720df6cee76c32
    125 N785977f18b4e4590bb6303380e68e1cf
    126 N9f32b1208eaf40fca2065c66303da8ed
    127 Ndc7a7c3f28d54f0f874a5786ef57811f
    128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049615868
    129 https://doi.org/10.1038/70928
    130 schema:sdDatePublished 2019-04-11T12:23
    131 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    132 schema:sdPublisher N0f291ad583454396a89c7832b8ff8a3e
    133 schema:url http://www.nature.com/nm/journal/v5/n12/full/nm1299_1359.html
    134 sgo:license sg:explorer/license/
    135 sgo:sdDataset articles
    136 rdf:type schema:ScholarlyArticle
    137 N070130fb320643bba815b3d6e5d151a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Animals
    139 rdf:type schema:DefinedTerm
    140 N0ce23bc5aa8f47b49d57221371b848b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Vascular Endothelial Growth Factor A
    142 rdf:type schema:DefinedTerm
    143 N0d0c2adb606144a6989f0906ea642490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Vascular Endothelial Growth Factors
    145 rdf:type schema:DefinedTerm
    146 N0f20e94db95f40bbb52f803873af9eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Coronary Disease
    148 rdf:type schema:DefinedTerm
    149 N0f291ad583454396a89c7832b8ff8a3e schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 N127541f1276f4defafc060f62b60ac1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Recombinant Proteins
    153 rdf:type schema:DefinedTerm
    154 N17258ac21b354c3fbca023a1ad3e1a3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Lymphokines
    156 rdf:type schema:DefinedTerm
    157 N1e89799f87e84f21a0fd1ef75066564c schema:name nlm_unique_id
    158 schema:value 9502015
    159 rdf:type schema:PropertyValue
    160 N212d6dac2bf64082b9037bc9d5f591e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Retinal Vein
    162 rdf:type schema:DefinedTerm
    163 N2efb84413da64065ac7b813ea5417604 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Neovascularization, Pathologic
    165 rdf:type schema:DefinedTerm
    166 N42163ba068ed4bcc9ade8359a96978ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Neovascularization, Physiologic
    168 rdf:type schema:DefinedTerm
    169 N474eb519cdbd4933ae720df6cee76c32 schema:name pubmed_id
    170 schema:value 10581076
    171 rdf:type schema:PropertyValue
    172 N518e8f1fa5644720bc27253cca988605 schema:name Department of Molecular Oncology Genentech DNA Way South San Francisco, California 94080, USA. nf@gene.com
    173 rdf:type schema:Organization
    174 N5798c04f2a8f4bbd978cd14f1947fbd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Ischemia
    176 rdf:type schema:DefinedTerm
    177 N6e03f8aa012048c29d57c4eb64addef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Neoplasms, Experimental
    179 rdf:type schema:DefinedTerm
    180 N741c2db459154682a59f7f0a51eb31d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Mice, Knockout
    182 rdf:type schema:DefinedTerm
    183 N785977f18b4e4590bb6303380e68e1cf schema:name doi
    184 schema:value 10.1038/70928
    185 rdf:type schema:PropertyValue
    186 N94080ac9b9f34921b90903ddd786d497 schema:volumeNumber 5
    187 rdf:type schema:PublicationVolume
    188 N9f32b1208eaf40fca2065c66303da8ed schema:name dimensions_id
    189 schema:value pub.1049615868
    190 rdf:type schema:PropertyValue
    191 Na1f7b4aeefe04a7fa0d326601087c843 rdf:first Nd2b84336fb994fe79c5a193a5a244d5c
    192 rdf:rest rdf:nil
    193 Nadb06729c68b4d548db6fb77d5cf5b26 schema:affiliation N518e8f1fa5644720bc27253cca988605
    194 schema:familyName Ferrara
    195 schema:givenName N
    196 rdf:type schema:Person
    197 Nb1348f19b57c469faeeb9c566bc83f4e rdf:first Nadb06729c68b4d548db6fb77d5cf5b26
    198 rdf:rest Na1f7b4aeefe04a7fa0d326601087c843
    199 Nbdd9c93e6ca24ff990652d54022a5efc schema:issueNumber 12
    200 rdf:type schema:PublicationIssue
    201 Nc3ea5c3dacb3456daa032fc337add75d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Endothelial Growth Factors
    203 rdf:type schema:DefinedTerm
    204 Nc88817df33e742e2a6ef059802f97b63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Mice
    206 rdf:type schema:DefinedTerm
    207 Nd2b84336fb994fe79c5a193a5a244d5c schema:familyName Alitalo
    208 schema:givenName K
    209 rdf:type schema:Person
    210 Ndc7a7c3f28d54f0f874a5786ef57811f schema:name readcube_id
    211 schema:value ec5b1aed445b8e170cb80a076b8968b189dd736e8b040e455c945e9045af544b
    212 rdf:type schema:PropertyValue
    213 Ndd0e23cfc79d4c07bef1d7b7cba19975 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Growth Inhibitors
    215 rdf:type schema:DefinedTerm
    216 Ne55a9dc4077745f09dc549628c461a5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Humans
    218 rdf:type schema:DefinedTerm
    219 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    220 schema:name Medical and Health Sciences
    221 rdf:type schema:DefinedTerm
    222 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Clinical Sciences
    224 rdf:type schema:DefinedTerm
    225 sg:journal.1113716 schema:issn 1078-8956
    226 1546-170X
    227 schema:name Nature Medicine
    228 rdf:type schema:Periodical
    229 sg:pub.10.1007/bf03401749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083308871
    230 https://doi.org/10.1007/bf03401749
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/28867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020992380
    233 https://doi.org/10.1038/28867
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/34193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022991853
    236 https://doi.org/10.1038/34193
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/362841a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013132150
    239 https://doi.org/10.1038/362841a0
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/380435a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034005847
    242 https://doi.org/10.1038/380435a0
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/380439a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004384986
    245 https://doi.org/10.1038/380439a0
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/386671a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010094120
    248 https://doi.org/10.1038/386671a0
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/7434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013556778
    251 https://doi.org/10.1038/7434
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/7439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019073472
    254 https://doi.org/10.1038/7439
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/8379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052764754
    257 https://doi.org/10.1038/8379
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/9467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024593021
    260 https://doi.org/10.1038/9467
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nm0195-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008981922
    263 https://doi.org/10.1038/nm0195-27
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nm0398-336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001019213
    266 https://doi.org/10.1038/nm0398-336
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nm0596-534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004115692
    269 https://doi.org/10.1038/nm0596-534
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nm1095-1085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015306666
    272 https://doi.org/10.1038/nm1095-1085
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nm1296-1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049266422
    275 https://doi.org/10.1038/nm1296-1371
    276 rdf:type schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1074251153 schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1081594878 schema:CreativeWork
    279 https://app.dimensions.ai/details/publication/pub.1082876818 schema:CreativeWork
    280 https://app.dimensions.ai/details/publication/pub.1082876932 schema:CreativeWork
    281 https://app.dimensions.ai/details/publication/pub.1082906666 schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1082937240 schema:CreativeWork
    283 https://app.dimensions.ai/details/publication/pub.1082941424 schema:CreativeWork
    284 https://app.dimensions.ai/details/publication/pub.1082983681 schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1083175627 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1083235023 schema:CreativeWork
    287 https://app.dimensions.ai/details/publication/pub.1083288691 schema:CreativeWork
    288 https://doi.org/10.1001/archopht.1996.01100130062010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042755429
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1002/(sici)1097-0177(199708)209:4<418::aid-aja9>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1014132658
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1002/(sici)1097-0215(19980417)79:2<144::aid-ijc8>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1020532199
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1006/bbrc.1995.1194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009132218
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1006/dbio.1997.8639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001679701
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1016/s0002-9440(10)65582-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020592852
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1016/s0008-6363(98)00136-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580102
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1016/s0022-5223(98)70455-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002070685
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1016/s0092-8674(00)81010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023555380
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1016/s0092-8674(00)81402-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000555694
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1016/s0092-8674(00)81436-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037220480
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/s0092-8674(00)81731-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017592303
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/s0140-6736(94)93001-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048813911
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/s0140-6736(96)03361-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011642904
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/s0168-3659(97)00237-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014334783
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/s0735-1097(98)80321-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008827441
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/s0741-5214(98)70022-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025541721
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s0741-5214(98)70236-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043411175
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1016/s0955-0674(98)80137-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051213728
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1016/s1097-2765(00)80154-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051350511
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1056/nejm197108122850711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042994614
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1056/nejm197111182852108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031952402
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1056/nejm199412013312203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018716626
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1056/nejm199610243351707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001445619
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1073/pnas.92.23.10457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025801845
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1073/pnas.93.25.14765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045231712
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1073/pnas.95.15.8795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037720209
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1073/pnas.95.15.8829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003453811
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1073/pnas.96.6.3071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033899749
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1074/jbc.273.32.20556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707898
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1074/jbc.273.47.31273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009905008
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1083/jcb.141.7.1659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053361197
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1089/hum.1997.8.15-1737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271929
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1089/hum.1998.9.10-1481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272113
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1089/hum.1998.9.6-823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272311
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1093/emboj/18.2.363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001756212
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1093/emboj/18.4.882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027190331
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1093/hmg/7.13.2073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046478479
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1093/jnci/6.1.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083452034
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1093/jnci/89.2.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000810733
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1097/00041433-199704000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011304900
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1101/gad.13.3.295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021864540
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1126/science.275.5302.964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555783
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1126/science.276.5317.1423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556862
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1126/science.282.5388.468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562857
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1126/science.285.5433.1553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062566508
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1152/ajpheart.1994.267.4.h1263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082576665
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1152/ajpheart.1996.270.5.h1803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083003118
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1161/01.cir.88.1.208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030356097
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1161/01.cir.91.11.2793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063335927
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1161/01.cir.92.9.2463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336733
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1161/01.cir.92.9.365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336789
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1161/01.cir.97.12.1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022909671
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1161/01.cir.97.4.381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047156652
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1161/01.cir.98.19.2081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005139885
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1161/01.cir.98.25.2800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048432123
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1161/01.res.83.3.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011213963
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1172/jci117018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009887518
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1172/jci117378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037835837
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1172/jci117521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032289300
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1172/jci119740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045876259
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1172/jci6740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016003327
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1177/019262339902700115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016671596
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1210/edrv.18.1.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238390
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.3109/07357909809039771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001211057
    417 rdf:type schema:CreativeWork
     




    Preview window. Press ESC to close (or click here)


    ...