Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11-10

AUTHORS

Javier Verdu, Michael A. Buratovich, Elizabeth L. Wilder, Morris J. Birnbaum

ABSTRACT

Organismal size is determined by a tightly regulated mechanism that coordinates cell growth, cell proliferation and cell death. The Drosophila insulin receptor/Chico/Dp110 pathway regulates cell and organismal size. Here we show that genetic manipulation of the phosphoinositide-3-OH-kinase-dependent serine/threonine protein kinase Akt (protein kinase B) during development of the Drosophila imaginal disc affects cell and organ size in an autonomous manner. Ectopic expression of Akt does not affect cell-fate determination, apoptosis or proliferation rates in imaginal discs. Thus, Akt appears to stimulate intracellular pathways that specifically regulate cell and compartment size independently of cell proliferation in vivo. More... »

PAGES

500-506

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/70293

DOI

http://dx.doi.org/10.1038/70293

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008487521

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10587646


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