Cooperative symmetry-breaking by actin polymerization in a model for cell motility View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

Alexander van Oudenaarden, Julie A. Theriot

ABSTRACT

Polymerizing networks of actin filaments are capable of exerting significant mechanical forces, used by eukaryotic cells and their prokaryotic pathogens to change shape or to move. Here we show that small beads coated uniformly with a protein that catalyses actin polymerization are initially surrounded by symmetrical clouds of actin filaments. This symmetry is broken spontaneously, after which the beads undergo directional motion. We have developed a stochastic theory, in which each actin filament is modelled as an elastic brownian ratchet, that quantitatively accounts for the observed emergent symmetry-breaking behaviour. Symmetry-breaking can only occur for polymers that have a significant subunit off-rate, such as the biopolymers actin and tubulin. More... »

PAGES

493

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/70281

DOI

http://dx.doi.org/10.1038/70281

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047384683

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10587645


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