Neutralizing antibody directed against the HIV–1 envelope glycoprotein can completely block HIV–1/SIV chimeric virus infections of macaque monkeys View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-02

AUTHORS

R Shibata, T Igarashi, N Haigwood, A Buckler-White, R Ogert, W Ross, R Willey, M W Cho, M A Martin

ABSTRACT

Virus-specific antibodies protect individuals against a wide variety of viral infections. To assess whether human immunodeficiency virus type 1 (HIV-1) envelope-specific antibodies confer resistance against primate lentivirus infections, we purified immunoglobulin (IgG) from chimpanzees infected with several different HIV-1 isolates, and used this for passive immunization of pig-tailed macaques. These monkeys were subsequently challenged intravenously with a chimeric simian-human immunodeficiency virus (SHIV) bearing an envelope glycoprotein derived form HIV-1DH12, a dual-tropic primary virus isolate. Here we show that anti-SHIV neutralizing activity, determined in vitro using an assay measuring loss of infectivity, is the absolute requirement for antibody-mediated protection in vivo. Using an assay that measures 100% neutralization, the titer in plasma for complete protection of the SHIV-challenged macaques was in the range of 1:5-1:8. The HIV-1-specific neutralizing antibodies studied are able to bind to native gp120 present on infectious virus particles. Administration of non-neutralizing anti-HIV IgG neither inhibited nor enhanced a subsequent SHIV infection. More... »

PAGES

204-210

References to SciGraph publications

Journal

TITLE

Nature Medicine

ISSUE

2

VOLUME

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/5568

DOI

http://dx.doi.org/10.1038/5568

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010692125

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9930869


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Products, env", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Antibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Envelope Protein gp120", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunization, Passive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macaca nemestrina", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutralization Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pan troglodytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reassortant Viruses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Simian Acquired Immunodeficiency Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Load", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibata", 
        "givenName": "R", 
        "id": "sg:person.01140606310.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140606310.44"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Igarashi", 
        "givenName": "T", 
        "id": "sg:person.01246413773.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246413773.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Haigwood", 
        "givenName": "N", 
        "id": "sg:person.01211065657.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211065657.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Buckler-White", 
        "givenName": "A", 
        "id": "sg:person.01070436763.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070436763.94"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ogert", 
        "givenName": "R", 
        "id": "sg:person.01241637307.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241637307.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ross", 
        "givenName": "W", 
        "id": "sg:person.010141307622.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010141307622.92"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Willey", 
        "givenName": "R", 
        "id": "sg:person.01167543630.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167543630.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Cho", 
        "givenName": "M W", 
        "id": "sg:person.016035161747.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035161747.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Martin", 
        "givenName": "M A", 
        "id": "sg:person.013200235402.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013200235402.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-3-642-78536-8_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010676075", 
          "https://doi.org/10.1007/978-3-642-78536-8_12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(91)90848-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017837224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1297-1389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023373942", 
          "https://doi.org/10.1038/nm1297-1389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840030201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025875876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840030201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025875876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(96)80046-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028793317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199311183292102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029759864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/345622a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032293946", 
          "https://doi.org/10.1038/345622a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198710223171703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036302120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(94)90185-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036477197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0264-410x(94)90185-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036477197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/355728a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040588876", 
          "https://doi.org/10.1038/355728a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/514053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044833576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-2478(96)02563-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046278611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.2.542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053563793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1991.7.971", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059223344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1997.13.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.1997.13.733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059224615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075401023", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077872517", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078876903", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079023614", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082499937", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082559002", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082877343", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082903930", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082918984", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082957611", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083163696", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083225832", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-02", 
    "datePublishedReg": "1999-02-01", 
    "description": "Virus-specific antibodies protect individuals against a wide variety of viral infections. To assess whether human immunodeficiency virus type 1 (HIV-1) envelope-specific antibodies confer resistance against primate lentivirus infections, we purified immunoglobulin (IgG) from chimpanzees infected with several different HIV-1 isolates, and used this for passive immunization of pig-tailed macaques. These monkeys were subsequently challenged intravenously with a chimeric simian-human immunodeficiency virus (SHIV) bearing an envelope glycoprotein derived form HIV-1DH12, a dual-tropic primary virus isolate. Here we show that anti-SHIV neutralizing activity, determined in vitro using an assay measuring loss of infectivity, is the absolute requirement for antibody-mediated protection in vivo. Using an assay that measures 100% neutralization, the titer in plasma for complete protection of the SHIV-challenged macaques was in the range of 1:5-1:8. The HIV-1-specific neutralizing antibodies studied are able to bind to native gp120 present on infectious virus particles. Administration of non-neutralizing anti-HIV IgG neither inhibited nor enhanced a subsequent SHIV infection.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/5568", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2723024", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2708528", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Neutralizing antibody directed against the HIV\u20131 envelope glycoprotein\ncan completely block HIV\u20131/SIV chimeric virus infections of macaque\nmonkeys", 
    "pagination": "204-210", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "32f01a7583aa49e0dc3d74d49e86406e929ae8ea856ce75a76d032d24f11e8d4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9930869"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/5568"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010692125"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/5568", 
      "https://app.dimensions.ai/details/publication/pub.1010692125"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70031_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/nm/journal/v5/n2/full/nm0299_204.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/5568'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/5568'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/5568'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/5568'


 

This table displays all metadata directly associated to this object as RDF triples.

257 TRIPLES      21 PREDICATES      72 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/5568 schema:about N09ebc451fd484e2dab789cb9f26442ec
2 N0aab6f8280aa497d9be3a866b852731d
3 N0d1ece9300e84a16ae3586eb6ef52d15
4 N1517be43456f4aefb97b071813083fb8
5 N3395ac603cf948f8831da9e9a7384055
6 N5724042138b64530bb0a959310c74719
7 N792963fae307456a844093e7d4cb096b
8 N7f5b3b3165c54027b490c76485fa16a9
9 N86ff71f778be4da695c6f191a750d2d4
10 N94274873b2004e71a404e7d01c24cedd
11 N94803200d64e46989d60bc690a5d87fd
12 Nb3c5cef5cfe9435fa0ba1d22f2dddcba
13 Nba381ee73c82432d8b7e93cb668849b1
14 Nc80582b1acf74f79a5b61e5c5b05bb2d
15 Ndf5da6a3b5994a688aa79a78a821fc6f
16 anzsrc-for:11
17 anzsrc-for:1108
18 schema:author N263964ce839349959303b59c01f63053
19 schema:citation sg:pub.10.1007/978-3-642-78536-8_12
20 sg:pub.10.1038/345622a0
21 sg:pub.10.1038/355728a0
22 sg:pub.10.1038/nm1297-1389
23 https://app.dimensions.ai/details/publication/pub.1075401023
24 https://app.dimensions.ai/details/publication/pub.1077872517
25 https://app.dimensions.ai/details/publication/pub.1078876903
26 https://app.dimensions.ai/details/publication/pub.1079023614
27 https://app.dimensions.ai/details/publication/pub.1082499937
28 https://app.dimensions.ai/details/publication/pub.1082559002
29 https://app.dimensions.ai/details/publication/pub.1082877343
30 https://app.dimensions.ai/details/publication/pub.1082903930
31 https://app.dimensions.ai/details/publication/pub.1082918984
32 https://app.dimensions.ai/details/publication/pub.1082957611
33 https://app.dimensions.ai/details/publication/pub.1083163696
34 https://app.dimensions.ai/details/publication/pub.1083225832
35 https://doi.org/10.1002/hep.1840030201
36 https://doi.org/10.1016/0042-6822(91)90848-6
37 https://doi.org/10.1016/0165-2478(96)02563-1
38 https://doi.org/10.1016/0264-410x(94)90185-6
39 https://doi.org/10.1016/s0952-7915(96)80046-x
40 https://doi.org/10.1056/nejm198710223171703
41 https://doi.org/10.1056/nejm199311183292102
42 https://doi.org/10.1073/pnas.88.2.542
43 https://doi.org/10.1086/514053
44 https://doi.org/10.1089/aid.1991.7.971
45 https://doi.org/10.1089/aid.1997.13.377
46 https://doi.org/10.1089/aid.1997.13.733
47 schema:datePublished 1999-02
48 schema:datePublishedReg 1999-02-01
49 schema:description Virus-specific antibodies protect individuals against a wide variety of viral infections. To assess whether human immunodeficiency virus type 1 (HIV-1) envelope-specific antibodies confer resistance against primate lentivirus infections, we purified immunoglobulin (IgG) from chimpanzees infected with several different HIV-1 isolates, and used this for passive immunization of pig-tailed macaques. These monkeys were subsequently challenged intravenously with a chimeric simian-human immunodeficiency virus (SHIV) bearing an envelope glycoprotein derived form HIV-1DH12, a dual-tropic primary virus isolate. Here we show that anti-SHIV neutralizing activity, determined in vitro using an assay measuring loss of infectivity, is the absolute requirement for antibody-mediated protection in vivo. Using an assay that measures 100% neutralization, the titer in plasma for complete protection of the SHIV-challenged macaques was in the range of 1:5-1:8. The HIV-1-specific neutralizing antibodies studied are able to bind to native gp120 present on infectious virus particles. Administration of non-neutralizing anti-HIV IgG neither inhibited nor enhanced a subsequent SHIV infection.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N2a7edc796af64e04a41ee335692669f9
54 N82667bb58af34ef98bae72a5e254a235
55 sg:journal.1113716
56 schema:name Neutralizing antibody directed against the HIV–1 envelope glycoprotein can completely block HIV–1/SIV chimeric virus infections of macaque monkeys
57 schema:pagination 204-210
58 schema:productId N092c6e71ac1b401199ca1e7b2ba3c99b
59 N45a6d6cd2d8d4f85873345a0df2bffcc
60 N520b0149584a4de7bb799501ac6a72b6
61 Nafbc19c49eff4a8ab5288048c6f3b502
62 Nb45febfbc3524fad89d23a40d9d6d65e
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010692125
64 https://doi.org/10.1038/5568
65 schema:sdDatePublished 2019-04-11T12:36
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher Nae5dfef9a99647e895eb9aad1eb1fa54
68 schema:url http://www.nature.com/nm/journal/v5/n2/full/nm0299_204.html
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N092c6e71ac1b401199ca1e7b2ba3c99b schema:name dimensions_id
73 schema:value pub.1010692125
74 rdf:type schema:PropertyValue
75 N09ebc451fd484e2dab789cb9f26442ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Neutralization Tests
77 rdf:type schema:DefinedTerm
78 N0aab6f8280aa497d9be3a866b852731d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Simian Acquired Immunodeficiency Syndrome
80 rdf:type schema:DefinedTerm
81 N0d1ece9300e84a16ae3586eb6ef52d15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Reassortant Viruses
83 rdf:type schema:DefinedTerm
84 N1517be43456f4aefb97b071813083fb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name HIV Envelope Protein gp120
86 rdf:type schema:DefinedTerm
87 N263964ce839349959303b59c01f63053 rdf:first sg:person.01140606310.44
88 rdf:rest N84049aa01d1f415385924d249a327982
89 N2a7edc796af64e04a41ee335692669f9 schema:issueNumber 2
90 rdf:type schema:PublicationIssue
91 N3395ac603cf948f8831da9e9a7384055 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Viral Load
93 rdf:type schema:DefinedTerm
94 N36cfbc95fc97413c9b93f0dfe4211a7b rdf:first sg:person.01211065657.46
95 rdf:rest Ned2df3a5c29d490788d7bb22bc2919a1
96 N45a6d6cd2d8d4f85873345a0df2bffcc schema:name doi
97 schema:value 10.1038/5568
98 rdf:type schema:PropertyValue
99 N520b0149584a4de7bb799501ac6a72b6 schema:name pubmed_id
100 schema:value 9930869
101 rdf:type schema:PropertyValue
102 N5724042138b64530bb0a959310c74719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 N6edf9d61a26f410797a878635ba8fcda rdf:first sg:person.01241637307.25
106 rdf:rest Na15cfad51f614fb6a9c0d0c7e2bc7ace
107 N792963fae307456a844093e7d4cb096b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Immunization, Passive
109 rdf:type schema:DefinedTerm
110 N7f5b3b3165c54027b490c76485fa16a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Pan troglodytes
112 rdf:type schema:DefinedTerm
113 N82667bb58af34ef98bae72a5e254a235 schema:volumeNumber 5
114 rdf:type schema:PublicationVolume
115 N8269263b7f7548368c03cb28fd019425 rdf:first sg:person.016035161747.09
116 rdf:rest N96b781ba8a0d428e8a9d344c890fde85
117 N84049aa01d1f415385924d249a327982 rdf:first sg:person.01246413773.09
118 rdf:rest N36cfbc95fc97413c9b93f0dfe4211a7b
119 N86ff71f778be4da695c6f191a750d2d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name HIV Infections
121 rdf:type schema:DefinedTerm
122 N94274873b2004e71a404e7d01c24cedd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Macaca
124 rdf:type schema:DefinedTerm
125 N94803200d64e46989d60bc690a5d87fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N96b781ba8a0d428e8a9d344c890fde85 rdf:first sg:person.013200235402.41
129 rdf:rest rdf:nil
130 Na15cfad51f614fb6a9c0d0c7e2bc7ace rdf:first sg:person.010141307622.92
131 rdf:rest Na1cfcbeb23e14d8f8b0ac1859887d16f
132 Na1cfcbeb23e14d8f8b0ac1859887d16f rdf:first sg:person.01167543630.32
133 rdf:rest N8269263b7f7548368c03cb28fd019425
134 Nae5dfef9a99647e895eb9aad1eb1fa54 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Nafbc19c49eff4a8ab5288048c6f3b502 schema:name nlm_unique_id
137 schema:value 9502015
138 rdf:type schema:PropertyValue
139 Nb3c5cef5cfe9435fa0ba1d22f2dddcba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name HIV-1
141 rdf:type schema:DefinedTerm
142 Nb45febfbc3524fad89d23a40d9d6d65e schema:name readcube_id
143 schema:value 32f01a7583aa49e0dc3d74d49e86406e929ae8ea856ce75a76d032d24f11e8d4
144 rdf:type schema:PropertyValue
145 Nba381ee73c82432d8b7e93cb668849b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Macaca nemestrina
147 rdf:type schema:DefinedTerm
148 Nc80582b1acf74f79a5b61e5c5b05bb2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name HIV Antibodies
150 rdf:type schema:DefinedTerm
151 Ndf5da6a3b5994a688aa79a78a821fc6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Gene Products, env
153 rdf:type schema:DefinedTerm
154 Ned2df3a5c29d490788d7bb22bc2919a1 rdf:first sg:person.01070436763.94
155 rdf:rest N6edf9d61a26f410797a878635ba8fcda
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical Microbiology
161 rdf:type schema:DefinedTerm
162 sg:grant.2708528 http://pending.schema.org/fundedItem sg:pub.10.1038/5568
163 rdf:type schema:MonetaryGrant
164 sg:grant.2723024 http://pending.schema.org/fundedItem sg:pub.10.1038/5568
165 rdf:type schema:MonetaryGrant
166 sg:journal.1113716 schema:issn 1078-8956
167 1546-170X
168 schema:name Nature Medicine
169 rdf:type schema:Periodical
170 sg:person.010141307622.92 schema:familyName Ross
171 schema:givenName W
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010141307622.92
173 rdf:type schema:Person
174 sg:person.01070436763.94 schema:familyName Buckler-White
175 schema:givenName A
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070436763.94
177 rdf:type schema:Person
178 sg:person.01140606310.44 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
179 schema:familyName Shibata
180 schema:givenName R
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140606310.44
182 rdf:type schema:Person
183 sg:person.01167543630.32 schema:familyName Willey
184 schema:givenName R
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167543630.32
186 rdf:type schema:Person
187 sg:person.01211065657.46 schema:familyName Haigwood
188 schema:givenName N
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211065657.46
190 rdf:type schema:Person
191 sg:person.01241637307.25 schema:familyName Ogert
192 schema:givenName R
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241637307.25
194 rdf:type schema:Person
195 sg:person.01246413773.09 schema:familyName Igarashi
196 schema:givenName T
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246413773.09
198 rdf:type schema:Person
199 sg:person.013200235402.41 schema:familyName Martin
200 schema:givenName M A
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013200235402.41
202 rdf:type schema:Person
203 sg:person.016035161747.09 schema:familyName Cho
204 schema:givenName M W
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016035161747.09
206 rdf:type schema:Person
207 sg:pub.10.1007/978-3-642-78536-8_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010676075
208 https://doi.org/10.1007/978-3-642-78536-8_12
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/345622a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032293946
211 https://doi.org/10.1038/345622a0
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/355728a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040588876
214 https://doi.org/10.1038/355728a0
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nm1297-1389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023373942
217 https://doi.org/10.1038/nm1297-1389
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1075401023 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1077872517 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1078876903 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1079023614 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1082499937 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1082559002 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1082877343 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082903930 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1082918984 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1082957611 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1083163696 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1083225832 schema:CreativeWork
231 https://doi.org/10.1002/hep.1840030201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025875876
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/0042-6822(91)90848-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017837224
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/0165-2478(96)02563-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046278611
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0264-410x(94)90185-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036477197
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0952-7915(96)80046-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028793317
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejm198710223171703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036302120
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1056/nejm199311183292102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029759864
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1073/pnas.88.2.542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053563793
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1086/514053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044833576
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1089/aid.1991.7.971 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059223344
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1089/aid.1997.13.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224562
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1089/aid.1997.13.733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059224615
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.419681.3 schema:alternateName National Institute of Allergy and Infectious Diseases
256 schema:name Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
257 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...