T-cell co-stimulation through B7RP-1 and ICOS View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

Steven K. Yoshinaga, John S. Whoriskey, Sanjay D. Khare, Ulla Sarmiento, Jane Guo, Tom Horan, Grace Shih, Ming Zhang, Marco A. Coccia, Tadahiko Kohno, Anna Tafuri-Bladt, David Brankow, Pauline Campbell, David Chang, Laura Chiu, Tianang Dai, Gordon Duncan, Gary S. Elliott, Ariela Hui, Susan M. McCabe, Sheila Scully, Arda Shahinian, Christine L. Shaklee, Gwyneth Van, Tak W. Mak, Giorgio Senaldi

ABSTRACT

T-cell activation requires co-stimulation through receptors such as CD28 and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine costimulatory receptor-ligand pair. The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells. The ligand, which has homology to B7 molecules and is called B7-related protein-1 (B7RP-1), is expressed on B cells and macrophages. ICOS and B7RP-I do not interact with proteins in the CD28-B7 pathway, and B7RP-1 co-stimulates T cells in vitro independently of CD28. Transgenic mice expressing a B7RP-1-Fc fusion protein show lymphoid hyperplasia in the spleen, lymph nodes and Peyer's patches. Presensitized mice treated with B7RP-1-Fc during antigen challenge show enhanced hypersensitivity. Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo. ICOS and B7RP-1 define a new and distinct receptor-ligand pair that is structurally related to CD28-B7 and is involved in the adaptive immune response. More... »

PAGES

827

Journal

TITLE

Nature

ISSUE

6763

VOLUME

402

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/45582

    DOI

    http://dx.doi.org/10.1038/45582

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021098384

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10617205


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