Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-01

AUTHORS

Dezhi Liao, Xiaoqun Zhang, Richard O'Brien, Michael D. Ehlers, Richard L. Huganir

ABSTRACT

Many excitatory synapses are thought to be postsynaptically 'silent', possessing functional NMDA but lacking functional AMPA glutamate receptors. The acquisition of AMPA receptors at silent synapses may be important in synaptic plasticity and neuronal development. Here we characterize a possible morphological correlate of silent synapses in cultured hippocampal neurons. Initially, most excitatory synapses contained NMDA receptors, but only a few contained detectable AMPA receptors. Synapses progressively acquired AMPA receptors as the cultures matured. AMPA receptor blockade increased the number, size and fluorescent intensity of AMPA receptor clusters and rapidly induced the appearance of AMPA receptors at 'silent' synapses. In contrast, NMDA receptor blockade increased the size, intensity and number of NMDA receptor clusters and decreased the number of AMPA receptor clusters, resulting in an increase in the proportion of 'silent' synapses. These results suggest that the number of silent synapses is regulated during development and by changes in synaptic activity. More... »

PAGES

37-43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/4540

DOI

http://dx.doi.org/10.1038/4540

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042452005

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10195178


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