Two subsets of memory T lymphocytes with distinct homing potentials and effector functions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-10

AUTHORS

Federica Sallusto, Danielle Lenig, Reinhold Förster, Martin Lipp, Antonio Lanzavecchia

ABSTRACT

Naive T lymphocytes travel to T-cell areas of secondary lymphoid organs in search of antigen presented by dendritic cells. Once activated, they proliferate vigorously, generating effector cells that can migrate to B-cell areas or to inflamed tissues. A fraction of primed T lymphocytes persists as circulating memory cells that can confer protection and give, upon secondary challenge, a qualitatively different and quantitatively enhanced response. The nature of the cells that mediate the different facets of immunological memory remains unresolved. Here we show that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets. CCR7- memory cells express receptors for migration to inflamed tissues and display immediate effector function. In contrast, CCR7+ memory cells express lymph-node homing receptors and lack immediate effector function, but efficiently stimulate dendritic cells and differentiate into CCR7- effector cells upon secondary stimulation. The CCR7+ and CCR7- T cells, which we have named central memory (TCM) and effector memory (TEM), differentiate in a step-wise fashion from naive T cells, persist for years after immunization and allow a division of labour in the memory response. More... »

PAGES

708

Journal

TITLE

Nature

ISSUE

6754

VOLUME

401

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/44385

DOI

http://dx.doi.org/10.1038/44385

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10537110


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