Tumour biology: Policing of oncogene activity by p53 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09

AUTHORS

Alejo Efeyan, Isabel Garcia-Cao, Daniel Herranz, Susana Velasco-Miguel, Manuel Serrano

ABSTRACT

The tumour-suppressor protein p53 provides the most important genetic defence against cancer1 and is activated in response to DNA damage and to oncogenic signalling, both of which occur almost universally in malignant tumours. But the relative contribution of these two pathways in inducing p53-dependent protection against cancer is unclear. Here we show that p53-dependent protection against cancer is lost in mice that have been genetically manipulated so that their p53 is activated in response to DNA damage but not to oncogenic signalling. We conclude that oncogenic signalling is the critical event that elicits p53-dependent protection and that the DNA-damage stimulus is less important. More... »

PAGES

159

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/443159a

DOI

http://dx.doi.org/10.1038/443159a

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015546171

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16971940


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