Casein kinase I transduces Wnt signals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-09

AUTHORS

John M. Peters, Renée M. McKay, James P. McKay, Jonathan M. Graff

ABSTRACT

The Wnt signalling cascade is essential for the development of both invertebrates and vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling has been elucidated, not all of the components have been identified. Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression cloning in Xenopus embryos. CKI reproduces several properties of Wnt signals, including generation of complete dorsal axes, stabilization of beta-catenin and induction of genes that are direct targets of Wnt signals. Dominant-negative forms of CKI and a pharmacological blocker of CKI inhibited Wnt signals in Xenopus. Inhibiting CKI in Caenorhabditis elegans generated worms with a mom phenotype, indicative of a loss of Wnt signals. In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway. More... »

PAGES

345

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/43830

DOI

http://dx.doi.org/10.1038/43830

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038591799

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10517632


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This table displays all metadata directly associated to this object as RDF triples.

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