Colorectal cancer: Mutations in a signalling pathway View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

D Williams Parsons, Tian-Li Wang, Yardena Samuels, Alberto Bardelli, Jordan M Cummins, Laura DeLong, Natalie Silliman, Janine Ptak, Steve Szabo, James K V Willson, Sanford Markowitz, Kenneth W Kinzler, Bert Vogelstein, Christoph Lengauer, Victor E Velculescu

ABSTRACT

Protein kinases are enzymes that are important for controlling cellular growth and invasion, and their malfunction is implicated in the development of some tumours. We analysed human colorectal cancers for genetic mutations in 340 serine/threonine kinases and found mutations in eight genes, including in three members of the phosphatidylinositol-3-OH kinase (PI(3)K) pathway. The discovery of this mutational activation of a key cell-signalling pathway may provide new targets for therapeutic intervention. More... »

PAGES

792-792

References to SciGraph publications

  • 2002-06. Mutations of the BRAF gene in human cancer in NATURE
  • 2001-05. Oncogenic kinase signalling in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2002-07. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/436792a

    DOI

    http://dx.doi.org/10.1038/436792a

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003531526

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16094359


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