Robustness in simple biochemical networks View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-06

AUTHORS

N Barkai, S Leibler

ABSTRACT

Cells use complex networks of interacting molecular components to transfer and process information. These "computational devices of living cells" are responsible for many important cellular processes, including cell-cycle regulation and signal transduction. Here we address the issue of the sensitivity of the networks to variations in their biochemical parameters. We propose a mechanism for robust adaptation in simple signal transduction networks. We show that this mechanism applies in particular to bacterial chemotaxis. This is demonstrated within a quantitative model which explains, in a unified way, many aspects of chemotaxis, including proper responses to chemical gradients. The adaptation property is a consequence of the network's connectivity and does not require the 'fine-tuning' of parameters. We argue that the key properties of biochemical networks should be robust in order to ensure their proper functioning. More... »

PAGES

913-917

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/43199

DOI

http://dx.doi.org/10.1038/43199

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003059937

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9202124


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