Ontology type: schema:ScholarlyArticle
1997-06
AUTHORS ABSTRACTWhen a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear. More... »
PAGES673-676
http://scigraph.springernature.com/pub.10.1038/42648
DOIhttp://dx.doi.org/10.1038/42648
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1030792601
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/9192891
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calcium-Binding Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Activation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Lipids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nerve Tissue Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphatidylinositol 3-Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphatidylinositols",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphotransferases (Alcohol Group Acceptor)",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Second Messenger Systems",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Synaptotagmins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "src Homology Domains",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Boston Biomedical Research Institute, 20 Staniford Street, 02114, Boston, Massachusetts, USA",
"id": "http://www.grid.ac/institutes/grid.280432.f",
"name": [
"Boston Biomedical Research Institute, 20 Staniford Street, 02114, Boston, Massachusetts, USA"
],
"type": "Organization"
},
"familyName": "Toker",
"givenName": "Alex",
"id": "sg:person.0673132256.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673132256.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cell Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, 330 Brook line Avenue, 02115, Boston, Massachusetts, USA",
"id": "http://www.grid.ac/institutes/grid.239395.7",
"name": [
"Department of Cell Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, 330 Brook line Avenue, 02115, Boston, Massachusetts, USA"
],
"type": "Organization"
},
"familyName": "Cantley",
"givenName": "Lewis C.",
"id": "sg:person.013560615677.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013560615677.26"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/382536a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044090038",
"https://doi.org/10.1038/382536a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/376599a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019263292",
"https://doi.org/10.1038/376599a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/370527a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052561899",
"https://doi.org/10.1038/370527a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/334353a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014945594",
"https://doi.org/10.1038/334353a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/378584a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029778580",
"https://doi.org/10.1038/378584a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/332644a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014093145",
"https://doi.org/10.1038/332644a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/384481a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026024700",
"https://doi.org/10.1038/384481a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1997-06",
"datePublishedReg": "1997-06-01",
"description": "When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear.",
"genre": "article",
"id": "sg:pub.10.1038/42648",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.2512835",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6634",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "387"
}
],
"keywords": [
"phosphoinositide-3-OH kinase",
"second messenger",
"enzyme phospholipase C",
"organelle membranes",
"cytoskeletal actin",
"cellular responses",
"lipid products",
"phospholipase C",
"cell membrane",
"key players",
"molecules bind",
"kinase",
"messenger",
"membrane",
"shape alterations",
"actin",
"binds",
"chemotaxis",
"phospholipids",
"cells",
"rearrangement",
"response",
"alterations",
"signals",
"players",
"exterior",
"action",
"interior",
"products",
"movement",
"transformation"
],
"name": "Signalling through the lipid products of phosphoinositide-3-OH kinase",
"pagination": "673-676",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1030792601"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/42648"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"9192891"
]
}
],
"sameAs": [
"https://doi.org/10.1038/42648",
"https://app.dimensions.ai/details/publication/pub.1030792601"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:53",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_296.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/42648"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/42648'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/42648'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/42648'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/42648'
This table displays all metadata directly associated to this object as RDF triples.
192 TRIPLES
21 PREDICATES
79 URIs
64 LITERALS
22 BLANK NODES