Signalling through the lipid products of phosphoinositide-3-OH kinase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-06

AUTHORS

Alex Toker, Lewis C. Cantley

ABSTRACT

When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second messenger transduces the signal to the interior of the cell. Second messengers can be derived from phospholipids in the membrane by the action of the enzymes phospholipase C or phosphoinositide-3-OH kinase (PI(3)K). PI(3)K is a key player in many cellular responses, including the movement of organelle membranes, shape alteration through rearrangement of cytoskeletal actin, transformation and chemotaxis. But how PI(3)K mediates these responses is only now becoming clear. More... »

PAGES

673-676

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/42648

DOI

http://dx.doi.org/10.1038/42648

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030792601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9192891


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